US4420461A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Agglutination-inhibition test kit for detecting immune complexes
Assignee: Ortho Clinical Diagnostics Inc
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Filing: 1982-05-26
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Granted: 1983-12-13
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Expires: 2002-05-26
Abstract
Abstract Kit for detecting circulating immune complexes containing endogenously bound Clq. Capillary tubes are filled with a mixture of Clq coated GPO reagent cells, rabbit anti-Clq antibodies, and precipitate from the biological fluid sample containing immune complexes. The mixture is allowed to react and the tubes read for the presence or absence of agglutination indicative of the absence or presence of said immune complexes respectively.
Inventors
- 👤 Rudolph P. Reckel
- 👤 Joanne L. Harris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:56
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/564
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
31 words
A kit for detecting immune complexes in a biological fluid, said immune complexes having endogenously bound Clq comprising: (a) human erythrocytes coated with purified Clq; and (b) rabbit anti-human Clq immunoglobulin.
Claim 2
Dependent Claim
31 words
A kit for detecting immune complexes in a biological fluid, said immune complexes having endogenously bound Clq comprising: (a) human erythrocytes coated with purified Clq; and (b) rabbit anti-human Clq immunoglobulin.
Claim 3
Dependent Claim
26 words
The kit as provided in claim 1 further comprising: (c) lyophilized human serum positive for immune complexes; and (d) lyophilized human serum negative for immune complexes.
Claim 4
Dependent Claim
55 words
The kit as provided in claim 2 further comprising: (e) a specimen diluent comprising disodium EDTA containing saline; (f) a precipitating reagent comprising borate buffer contain 3% polyethylene glycol 6000; (g) a wash solution comprising borate buffer containing 2.5% polyethylene glycol 6000; and (h) antibody diluent comprising phosphate buffer containing EDTA and bovine serum albumin.
Claim 5
Dependent Claim
14 words
The kit as provided in claim 3 further comprising at least one capillary tube.
References Cited (Backward Citations)
US3873684A
Cited
US4062935A
Cited
US4138213A
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US4283383A
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US4141965A
Cited
US4210622A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-12-12 | 1987-06-13 | 1987-12-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-12-12 | 1991-06-13 | 1991-12-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-12-12 | 1995-06-13 | 1995-12-13 | $7700.00 | Window Closed / Lapsed |