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US4415733A
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Ganglioside derivatives, their preparation and their application
Assignee: Institut Merieux SA
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Filing: 1981-03-16
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Granted: 1983-11-15
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Expires: 2001-03-16
Abstract
Abstract This invention has for its object new ganglioside derivatives, their preparation and their application.
Inventors
- 👤 Jean-Louis Tayot
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:18
CPC Classifications
C; C07; C07H; C07H15/00; C07H15/02; C07H15/04; C07H15/10; A; A61; A61K; A61K39/00; A61K39/02; A61K39/08; A61K39/107; B; B01; B01D; B01D15/00; B01D15/08; B01D15/26; B01D15/38; B01D15/3804; B01J; B01J20/00; B01J20/281; B01J20/286; B01J20/30; B01J20/32; B01J20/3214; B01J20/3217; B01J20/3219; B01J20/3231; B01J20/3242; B01J20/3244; B01J20/3246; B01J20/3248; B01J20/3255
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
123 words
A partially deacylated derivative of a ganglioside or glycolipid having an N-acyl group and being selected from G D1a , G D1b and G T1 gangliosides, said derivative exhibiting specific affinity properties when coupled to a solid support, wherein said derivative exhibits free amino groups that can be brought out by a positive reaction in the ninhydrin test, wherein also said derivative is mobile in chromatography on a thin silica gel layer in a 60:32:7 chloroform-methanol-water system, and wherein said derivative exhibits the specific affinity properties of the ganglioside or glycolipid from which it is derived, said derivative being capable of being coupled to a solid support by amino groups that have appeared during partial deacylation, without loss of said specific affinity properties.
Claim 2
Dependent Claim
123 words
A partially deacylated derivative of a ganglioside or glycolipid having an N-acyl group and being selected from G D1a , G D1b and G T1 gangliosides, said derivative exhibiting specific affinity properties when coupled to a solid support, wherein said derivative exhibits free amino groups that can be brought out by a positive reaction in the ninhydrin test, wherein also said derivative is mobile in chromatography on a thin silica gel layer in a 60:32:7 chloroform-methanol-water system, and wherein said derivative exhibits the specific affinity properties of the ganglioside or glycolipid from which it is derived, said derivative being capable of being coupled to a solid support by amino groups that have appeared during partial deacylation, without loss of said specific affinity properties.
Claim 3
Dependent Claim
13 words
The derivative of claim 1 wherein the ganglioside is ganglioside G D1a .
Claim 4
Dependent Claim
13 words
The derivative of claim 1 wherein the ganglioside is ganglioside G D1b .
Claim 5
Dependent Claim
13 words
The derivative of claim 1 wherein the ganglioside is ganglioside G T1 .
Claim 6
Dependent Claim
15 words
The derivative of claim 1 which is fixed on a solid organic or inorganic support.
Claim 7
Dependent Claim
33 words
The derivative of claim 5 wherein said support is a modified or unmodified organic polymer and wherein the ganglioside derivative is fixed on said support by amino groups that appeared during partial deacylation.
Claim 8
Dependent Claim
38 words
The derivative of claim 5 wherein said support is an inorganic porous body modified to make appear reactive groups capable of reacting with reactive groups of a coupling agent or with the NH 2 groups of said derivative.
References Cited (Backward Citations)
US4225487A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-14 | 1987-05-16 | 1987-11-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-14 | 1991-05-16 | 1991-11-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-14 | 1995-05-16 | 1995-11-15 | $7700.00 | Window Closed / Lapsed |