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US4414148A
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Anti-cancer drugs for the treatment of melanomas and method for preparing thereof
Assignee: Elf Sanofi SA
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Filing: 1982-04-14
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Granted: 1983-11-08
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Expires: 2002-04-14
Abstract
Abstract The present invention relates to drugs useful in particular for the treatment of melanomas, characterized in that they contain an active substance which is a molecule in which the chain A of ricin is associated, by a covalent bond of disulfide type, with a human antimelanoma antibody.
Inventors
- 👤 Franz K. Jansen
- 👤 Pierre Gros
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:37
CPC Classifications
A; A61; A61K; A61K39/00; A61K39/395; A61K39/44; C; C07; C07K; C07K16/00; C07K16/18; C07K16/28; C07K16/30; C07K16/3053; A61K47/00; A61K47/50; A61K47/51; A61K47/68; A61K47/6801; A61K47/6803; A61K47/6811; A61K47/6817; A61K47/6819; A61K47/6825; A61K47/6827; A61K47/6835; A61K47/6851; A61K47/6865; A61P; A61P35/00; A61K38/00; Y; Y10; Y10S; Y10S530/00; Y10S530/806; Y10S530/827; Y10S530/828
Claims Analysis
Total Claims: 5
Claim 1
Independent Claim
43 words
Drugs useful in particular for the treatment of melanomas, wherein they contain an active substance which is a molecule in which the chain A of ricin is associated, by a covalent bond of disulfide type, with the human antimelanoma antibody, Anti p. 97.
Claim 2
Dependent Claim
43 words
Drugs useful in particular for the treatment of melanomas, wherein they contain an active substance which is a molecule in which the chain A of ricin is associated, by a covalent bond of disulfide type, with the human antimelanoma antibody, Anti p. 97.
Claim 3
Dependent Claim
18 words
The drugs of claims 1, wherein they are in a form suitable for administration by the injectable route.
Claim 4
Dependent Claim
52 words
Method for preparing the active substance of the drug of claim 1, wherein the chain A of ricin-chain represented by the formula RASH-is reacted with a derivative of the antibody, Anti-p. 97, of formula AC--S--S--X in which X designates an activator radical, and AC designates Anti-p. 97, according to the equation: R--A--SH+AC--S--S--X→R--A--S--S--AC+XSH
Claim 5
Dependent Claim
35 words
The process of claim 3, wherein the radical X designates a group capable of reacting with a free thiol radical which may include substituted 2- or 4-pyridyl group, a phenyl group or an alkoxycarbonyl group.
References Cited (Backward Citations)
US4340535A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-11-07 | 1987-05-09 | 1987-11-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-11-07 | 1991-05-09 | 1991-11-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-11-07 | 1995-05-09 | 1995-11-08 | $7700.00 | Window Closed / Lapsed |