US4404206A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Substituted iminoacid derivatives, process for preparing them and their use as enzyme inhibitors
Assignee: Institut Servier de Medecine Translationnelle SARL
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Filing: 1980-12-03
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Granted: 1983-09-13
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Expires: 2000-12-03
Abstract
Abstract Bicyclic imino acids, particularly 2-carboxylic acid derivatives of azabicycloalkanes and process for preparing them. These compounds have therapeutical activity and may be used as medicines, particularly as cardiovascular and antihypertensive drugs in human or veterinary medicine.
Inventors
- 👤 Michel Vincent
- 👤 Georges Remond
- 👤 Michel Laubie
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:58
CPC Classifications
C; C07; C07D; C07D471/00; C07D471/02; C07D471/04; C07D209/00; C07D209/02; C07D209/04; C07D209/30; C07D209/42; C07D209/44; C07D217/00; C07D217/22; C07D217/26; C07D495/00; C07D495/02; C07D495/04; C07K; C07K5/00; C07K5/04; C07K5/06; C07K5/06008; C07K5/06017; C07K5/06026
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
109 words
A compound selected from the group consisting of bicyclic iminoacids of the formula I ##STR6## wherein A, m, and n are selected to provide a perhydroquinoline or perhydroisoquinoline ring system, q represents 0 or the number 1 or 2, R is hydrogen, methyl, or benzyl, R 1 is hydrogen or lower-alkyl of no more than 5 carbon atoms, R 2 is hydroxyl or lower-alkoxy of no more than 5 carbon atoms, and Z is carboxyl, cyano, hydroxyl, sulfhydryl, or amino, in racemic or optically-active form, and pharmaceutically-acceptable addition salts thereof, when R 2 is hydroxy with a mineral or organic base and, when Z is amino, with an acid.
Claim 2
Dependent Claim
109 words
A compound selected from the group consisting of bicyclic iminoacids of the formula I ##STR6## wherein A, m, and n are selected to provide a perhydroquinoline or perhydroisoquinoline ring system, q represents 0 or the number 1 or 2, R is hydrogen, methyl, or benzyl, R 1 is hydrogen or lower-alkyl of no more than 5 carbon atoms, R 2 is hydroxyl or lower-alkoxy of no more than 5 carbon atoms, and Z is carboxyl, cyano, hydroxyl, sulfhydryl, or amino, in racemic or optically-active form, and pharmaceutically-acceptable addition salts thereof, when R 2 is hydroxy with a mineral or organic base and, when Z is amino, with an acid.
Claim 3
Dependent Claim
2 words
2-[3-Mercapto-2-(RS)-methylpropionyl]-cis-perhydroisoquinoline-3-carboxylic acid.
Claim 4
Dependent Claim
2 words
2-[3-Mercapto-2-(RS)-methylpropionyl]-cis-perhydroisoquinoline-3-carboxylic acid.
Claim 5
Dependent Claim
1 words
1-(3-mercapto-2-(RS)-methylpropionyl)-2-(RS)-carboxyperhydroquinoline.
Claim 6
Dependent Claim
1 words
1-(3-mercapto-2-(RS)-methylpropionyl)-2-(RS)-carboxyperhydroquinoline.
Claim 7
Dependent Claim
33 words
Pharmaceutical composition, useful for treatment of high blood pressure and cardiac failure, containing as active ingredient a compound of claim 1 in admixture or conjunction with an inert, non-toxic, therapeutically-compatible carrier or vehicle.
Claim 8
Dependent Claim
20 words
A pharmaceutical composition as claimed in claim 4 in which the carrier is adapted for oral, parenteral, or rectal administration.
Claim 9
Dependent Claim
20 words
A pharmaceutical composition as claimed in claim 4 containing the active principle at the dose of 25 to 250 mg.
Claim 10
Dependent Claim
39 words
A method of treating high blood pressure and cardiac failure in a subject, which consists in administering to said subject an effective amount of a compound of claim 1 or a salt thereof together with a therapeutically suitable carrier.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-09-12 | 1987-03-14 | 1987-09-13 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-09-12 | 1991-03-14 | 1991-09-13 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-09-12 | 1995-03-14 | 1995-09-13 | $7700.00 | Window Closed / Lapsed |