US4398906A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method for externally treating the blood
Assignee: Edelson Trust
•
Filing: 1981-06-12
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Granted: 1983-08-16
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Expires: 2001-06-12
Abstract
Abstract A method and system are disclosed for externally treating human blood, with the objective of reducing the functioning lymphocyte population in the blood system of a human subject. According to the method, blood is withdrawn from the subject and passed through an ultraviolet radiation field in the presence of from about 1 nanogram to 100 micrograms per ml of blood, of a dissolved photoactive agent capable of forming photo-adducts with lymphocytic-DNA, mobile cortisone receptors or antigen sites to thereby effect covalent bonding between the photoactive agent and the same, thereby inhibiting the metabolic processes of the lymphocytes or complexing them; and thereupon returning the irradiated blood to the subject. The withdrawn blood may be formed into an extracorporeal stream and flowed through a treatment station whereat the irradiation is effected, as for example by exposure to UV radiation; and such flow process may be conducted on a continuous basis. If desired, at least portions of the treated blood may then be separated, as for example by a continuous centrifuge, before returning the remaining diverted blood to the subject.
Inventors
- 👤 Richard L. Edelson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:59
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3681; A61K; A61K41/00; A61K41/10; A61M1/3616; A61M1/3683; A61M1/3686; A61M1/3621; A61M1/3623; Y; Y10; Y10S; Y10S128/00; Y10S128/03
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
128 words
A method for reducing the functioning population of a nucleated cell in the blood supply of a human subject, comprising the steps of: withdrawing blood from said subject, and irradiating said withdrawn blood with UV radiation in the presence of from about 1 nanogram to 100 micrograms per ml of blood of a dissolved photoactive chemical agent having an affinity for the steroid receptors of the nucleated blood cell and capable when activated by said UV radiation of forming photo-adducts with said steroid receptors, to thereby effect chemical bonding between said photoactive chemical agent and said steroid receptors of the nucleated cells, thereby destroying the said receptors' ability to transmit cortisone and inhibiting the metabolic processes of said nucleated cells; and returning the irradiated blood to said subject.
Claim 2
Independent Claim
128 words
A method for reducing the functioning population of a nucleated cell in the blood supply of a human subject, comprising the steps of: withdrawing blood from said subject, and irradiating said withdrawn blood with UV radiation in the presence of from about 1 nanogram to 100 micrograms per ml of blood of a dissolved photoactive chemical agent having an affinity for the steroid receptors of the nucleated blood cell and capable when activated by said UV radiation of forming photo-adducts with said steroid receptors, to thereby effect chemical bonding between said photoactive chemical agent and said steroid receptors of the nucleated cells, thereby destroying the said receptors' ability to transmit cortisone and inhibiting the metabolic processes of said nucleated cells; and returning the irradiated blood to said subject.
Claim 3
Dependent Claim
20 words
A method in accordance with claim 1 wherein the nucleated cells are lymphocytes and said steroid receptors are cortisone receptors.
Claim 4
Dependent Claim
15 words
A method in accordance with claim 2, wherein said photoactive chemical agent is photoactivated cortisone.
Claim 5
Dependent Claim
13 words
A method in accordance with claim 3 wherein said photoactivated cortisone is 16-diazocortisone.
Claim 6
Dependent Claim
39 words
A method in accordance with claim 1 or 3 wherein said withdrawn blood is formed into an extracorporeal flowing stream, passed through a treatment station whereat said irradiation is effected and returned to said subject in a continuous operation.
Claim 7
Dependent Claim
27 words
A method in accordance with claim 3 including the further step of separating at least portions of said lymphocyte population before returning said blood to said subject.
Claim 8
Dependent Claim
36 words
A method in accordance with claim 3 including the further step of separating at least portions of said lymphocyte population before returning said blood to said subject, by passing said bloodstream through a continuous flow centrifuge.
Claim 9
Dependent Claim
35 words
A method in accordance with claim 7 wherein excess quantities of said photoactivated cortisone are removed from the extracorporeal stream by withdrawing blood plasma at said centrifuge and replacing same with fresh photoactivated cortisone-free plasma.
Claim 10
Dependent Claim
34 words
A method in accordance with claim 3 wherein said blood is irradiated with photoenergy in the UVA wavelength range, and at a radiation dose level of from about 0.1 to 100 joules/cm 2 .
Claim 11
Dependent Claim
30 words
A method in accordance with claim 3 wherein said photoactivated cortisone is dissolved in said blood by mixing same with said blood subsequent to withdrawing the blood from said subject.
Claim 12
Dependent Claim
24 words
A method in accordance with claim 3 wherein said photoactivated cortisone is dissolved in said blood by administering said photoactivated cortisone to said subject.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1986-08-15 | 1987-02-14 | 1987-08-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1990-08-15 | 1991-02-14 | 1991-08-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1994-08-15 | 1995-02-14 | 1995-08-16 | $7700.00 | Window Closed / Lapsed |