Patent US4363319A successfully refreshed from Google Patents.
US4363319A
Expired / Lapsed
US
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Ready-to-use bandage incorporating a coagulant composition and method of preparing same
Assignee: Gentrac Inc
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Filing: 1981-04-20
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Granted: 1982-12-14
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Expires: 2001-04-20
Abstract
Abstract A prepackaged coagulant composition and method of preparing same has been devised for use in direct or topical application to wounds so as to cause superficial clotting in which thrombin is combined with special preservatives and a saline solution. A ready-to-use bandage is saturated with the resultant solution, sealed and stored so as not to lose its reactive properties with the fibrinogen in the blood when applied to a wound or cut.
Inventors
- 👤 John H. Altshuler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 19:33
CPC Classifications
C; C12; C12N; C12N9/00; C12N9/14; C12N9/48; C12N9/50; C12N9/64; C12N9/6421; C12N9/6424; C12N9/6429; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; C12Y; C12Y304/00; C12Y304/21; C12Y304/21005; A61K; A61K38/00; A61L2400/00; A61L2400/04
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
47 words
A coagulant adaptable for use as a dressing for wounds comprising a solution of 50-2000 units of thrombin per ml of an aqueous solution containing sodium chloride in about isotonic quantities and from 10-50% by weight of a straight chain 3 to 6 carbon fully hydroxylated polyol.
Claim 2
Dependent Claim
47 words
A coagulant adaptable for use as a dressing for wounds comprising a solution of 50-2000 units of thrombin per ml of an aqueous solution containing sodium chloride in about isotonic quantities and from 10-50% by weight of a straight chain 3 to 6 carbon fully hydroxylated polyol.
Claim 3
Dependent Claim
20 words
The coagulant of claim 1 wherein the solution contains also a sulfur-free essential amino acid in molar proportions of 0.01-0.25.
Claim 4
Dependent Claim
12 words
The coagulant composition of claim 2 wherein said amino acid is lysine.
Claim 5
Dependent Claim
16 words
The coagulant composition of claim 2 wherein said solution contains a combination of glycerol and lysine.
Claim 6
Dependent Claim
27 words
The coagulant of claim 2 wherein the solution contains also from 0.1-4.0% by wt. of a polyethylene glycol of a molecular weight in the range of 2,500-6000.
Claim 7
Dependent Claim
15 words
The coagulant composition of claim 5 where said solution contains glycerol, lysine and polyethylene glycol.
Claim 8
Dependent Claim
19 words
The coagulant composition of claim 1 wherein glycerol is present as about 30 parts by volume of the solution.
Claim 9
Dependent Claim
63 words
A prepackaged coagulant material adaptable for use as bandages, dressings and the like for wounds comprising in combination: a solution of thrombin containing sodium chloride in about isotonic proportions together with from 10-50% by weight of a straight chain 3 to 6 carbon fully hydroxylated polyol, and an absorbent material saturated by said solution, and sealing means hermetically sealing said saturated absorbent material.
Claim 10
Dependent Claim
63 words
A prepackaged coagulant material adaptable for use as bandages, dressings and the like for wounds comprising in combination: a solution of thrombin containing sodium chloride in about isotonic proportions together with from 10-50% by weight of a straight chain 3 to 6 carbon fully hydroxylated polyol, and an absorbent material saturated by said solution, and sealing means hermetically sealing said saturated absorbent material.
Claim 11
Dependent Claim
24 words
The prepackaged coagulant material of claim 8, said thrombin being present in the range of 25 to 250 units per cc. of absorbent material.
Claim 12
Dependent Claim
21 words
The prepackaged coagulant material of claim 8, said solution including therein a sulfur-free essential amino acid in molar proportions of 0.01-0.25.
Claim 13
Dependent Claim
11 words
The prepackaged coagulant material of claim 10, said solution containing lysine.
Claim 14
Dependent Claim
13 words
The prepackaged coagulant material of claim 11, said solution containing glycerol and lysine.
Claim 15
Dependent Claim
26 words
The prepackaged coagulant material of claim 10, said solution containing from 0.1-4.0% by weight of a polyethylene glycol of molecular weight in the range of 2,500-6,000.
Claim 16
Dependent Claim
15 words
The prepackaged coagulant material of claim 13, said solution containing glycerol, lysine and polyethylene glycol.
Claim 17
Dependent Claim
20 words
The prepackaged coagulant material of claim 8, said solution including therein glycerol as about 30 parts volume of the solution.
Claim 18
Dependent Claim
24 words
The prepackaged coagulant material of claim 8 in a ready-to-use bandage form containing about 25.0 units of thrombin per CM 3 of pad material.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-12-13 | 1986-06-14 | 1986-12-14 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-12-13 | 1990-06-14 | 1990-12-14 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-12-13 | 1994-06-14 | 1994-12-14 | $7700.00 | Window Closed / Lapsed |