Patent US4355028A successfully refreshed from Google Patents.
US4355028A
Expired / Lapsed
US
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Composition for treating acne vulgaris
Assignee: Westwood Pharmaceuticals Inc
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Filing: 1981-04-30
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Granted: 1982-10-19
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Expires: 2001-04-30
Abstract
Abstract Procedure for treating acne vulgaris that uses salicylic acid and benzoyl peroxide either sequentially or simultaneously. Compositions for practicing each of these aspects of the invention are also described.
Inventors
- 👤 Albert M. Kligman
- 👤 Walter L. McKenzie
- 👤 Peter F. Ciesla
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:43
CPC Classifications
A; A61; A61Q; A61Q19/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/368; A61K8/38
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
207 words
A topical, therapeutic composition comprising from about 3% to about 7% salicylic acid and from 3% to about 20% benzoyl peroxide in a pharmaceutically acceptable vehicle comprising an aqueous gel containing an amount sufficient to produce a stable gel of a gelling and thickening agent selected from the group consisting of a mixture of about 1 to about 3% by weight magnesium aluminum silicate with about 1 to about 3% by weight of methyl cellulose, wherein the combined amount of the magnesium aluminum silicate and the methyl cellulose does not exceed about 5% by weight; about 7 to about 9% by weight of magnesium aluminum silicate; about 2 to about 5% by weight methyl cellulose; about 1 to about 3% by weight pectin; about 2 to about 4% by weight xanthan gum; about 4 to about 6% by weight polyethylene oxide having an average molecular weight of about 400,000; about 5 to about 7% by weight polyethylene oxide having an average molecular weight of about 300,000; about 3 to about 5% by weight polyethylene oxide having an average molecular weight of about 600,000; about 1 to about 3% by weight polyacrylamide; and about 2 to about 4% by weight of a 1:1 mixture of hectorite and hydroxyethylcellulose.
Claim 2
Dependent Claim
207 words
A topical, therapeutic composition comprising from about 3% to about 7% salicylic acid and from 3% to about 20% benzoyl peroxide in a pharmaceutically acceptable vehicle comprising an aqueous gel containing an amount sufficient to produce a stable gel of a gelling and thickening agent selected from the group consisting of a mixture of about 1 to about 3% by weight magnesium aluminum silicate with about 1 to about 3% by weight of methyl cellulose, wherein the combined amount of the magnesium aluminum silicate and the methyl cellulose does not exceed about 5% by weight; about 7 to about 9% by weight of magnesium aluminum silicate; about 2 to about 5% by weight methyl cellulose; about 1 to about 3% by weight pectin; about 2 to about 4% by weight xanthan gum; about 4 to about 6% by weight polyethylene oxide having an average molecular weight of about 400,000; about 5 to about 7% by weight polyethylene oxide having an average molecular weight of about 300,000; about 3 to about 5% by weight polyethylene oxide having an average molecular weight of about 600,000; about 1 to about 3% by weight polyacrylamide; and about 2 to about 4% by weight of a 1:1 mixture of hectorite and hydroxyethylcellulose.
Claim 3
Dependent Claim
15 words
A composition according to claim 1 containing about 5% salicylic acid and 5% benzoyl peroxide.
Claim 4
Dependent Claim
28 words
A composition according to claim 1 wherein said agent is a mixture of about 2% by weight of magnesium aluminum silicate and about 1.25% by weight of methylcellulose.
Claim 5
Dependent Claim
17 words
A composition according to claim 3 further including about 1% by weight of modified cold process starch.
Claim 6
Dependent Claim
37 words
A composition according to claim 4 further including an amount of a sequestering agent sufficient to sequester metal ions present in the composition which may complex with the salicylic acid and promote decomposition of the benzoyl peroxide.
Claim 7
Dependent Claim
26 words
The composition according to claim 5 wherein the sequestering agent is disodium EDTA or EDTA and is present in an amount of about 0.1% by weight.
Claim 8
Dependent Claim
41 words
A composition according to claim 6 further including about 6% by weight of a compound having the formula CH 3 (CH 2 ) 10 CH 2 (OCH 2 CH 2 ) n OH wherein n has an average value of 4.
Claim 9
Dependent Claim
24 words
A composition according to claim 1 wherein said agent is magnesium aluminum silicate and is present in an amount of about 8% by weight.
Claim 10
Dependent Claim
24 words
A composition according to claim 1 wherein said agent is methylcellulose and is present in an amount of about 3 to 4% by weight.
Claim 11
Dependent Claim
22 words
A composition according to claim 1 wherein said agent is pectin and is present in an amount of about 2% by weight.
Claim 12
Dependent Claim
23 words
A composition according to claim 1 wherein said agent is xanthan gum and is present in an amount of about 3% by weight.
Claim 13
Dependent Claim
31 words
A composition according to claim 1 wherein said agent is polyethylene oxide having an average molecular weight of about 400,000, and is present in an amount of about 5% by weight.
Claim 14
Dependent Claim
31 words
A composition according to claim 1 wherein said agent is polyethylene oxide having an average molecular weight of about 300,000 and is present in an amount of about 6% by weight.
Claim 15
Dependent Claim
31 words
A composition according to claim 1 wherein said agent is polyethylene oxide having an average molecular weight of about 600,000 and is present in an amount of about 6% by weight.
Claim 16
Dependent Claim
22 words
A composition according to claim 1 wherein said agent is polyacrylamide and is present in an amount of about 2% by weight.
Claim 17
Dependent Claim
28 words
A composition according to claim 1 wherein said agent is a 1:1 mixture of hectorite and hydroxyethylcellulose and is present in an amount of about 3% by weight.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1985-10-18 | 1986-04-19 | 1986-10-19 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1989-10-18 | 1990-04-19 | 1990-10-19 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1993-10-18 | 1994-04-19 | 1994-10-19 | $7700.00 | Window Closed / Lapsed |