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US4355028A Expired / Lapsed US ⏱️ 0.0 years remaining

Composition for treating acne vulgaris

Assignee: Westwood Pharmaceuticals Inc
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Filing: 1981-04-30
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Granted: 1982-10-19
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Expires: 2001-04-30
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Abstract

Abstract Procedure for treating acne vulgaris that uses salicylic acid and benzoyl peroxide either sequentially or simultaneously. Compositions for practicing each of these aspects of the invention are also described.

Inventors

  • 👤 Albert M. Kligman
  • 👤 Walter L. McKenzie
  • 👤 Peter F. Ciesla

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 16:43
CPC Classifications
A; A61; A61Q; A61Q19/00; A61K; A61K8/00; A61K8/18; A61K8/30; A61K8/33; A61K8/36; A61K8/368; A61K8/38

Claims Analysis

Total Claims: 17
Claim 1
Independent Claim 207 words
A topical, therapeutic composition comprising from about 3% to about 7% salicylic acid and from 3% to about 20% benzoyl peroxide in a pharmaceutically acceptable vehicle comprising an aqueous gel containing an amount sufficient to produce a stable gel of a gelling and thickening agent selected from the group consisting of a mixture of about 1 to about 3% by weight magnesium aluminum silicate with about 1 to about 3% by weight of methyl cellulose, wherein the combined amount of the magnesium aluminum silicate and the methyl cellulose does not exceed about 5% by weight; about 7 to about 9% by weight of magnesium aluminum silicate; about 2 to about 5% by weight methyl cellulose; about 1 to about 3% by weight pectin; about 2 to about 4% by weight xanthan gum; about 4 to about 6% by weight polyethylene oxide having an average molecular weight of about 400,000; about 5 to about 7% by weight polyethylene oxide having an average molecular weight of about 300,000; about 3 to about 5% by weight polyethylene oxide having an average molecular weight of about 600,000; about 1 to about 3% by weight polyacrylamide; and about 2 to about 4% by weight of a 1:1 mixture of hectorite and hydroxyethylcellulose.
Claim 2
Dependent Claim 207 words
A topical, therapeutic composition comprising from about 3% to about 7% salicylic acid and from 3% to about 20% benzoyl peroxide in a pharmaceutically acceptable vehicle comprising an aqueous gel containing an amount sufficient to produce a stable gel of a gelling and thickening agent selected from the group consisting of a mixture of about 1 to about 3% by weight magnesium aluminum silicate with about 1 to about 3% by weight of methyl cellulose, wherein the combined amount of the magnesium aluminum silicate and the methyl cellulose does not exceed about 5% by weight; about 7 to about 9% by weight of magnesium aluminum silicate; about 2 to about 5% by weight methyl cellulose; about 1 to about 3% by weight pectin; about 2 to about 4% by weight xanthan gum; about 4 to about 6% by weight polyethylene oxide having an average molecular weight of about 400,000; about 5 to about 7% by weight polyethylene oxide having an average molecular weight of about 300,000; about 3 to about 5% by weight polyethylene oxide having an average molecular weight of about 600,000; about 1 to about 3% by weight polyacrylamide; and about 2 to about 4% by weight of a 1:1 mixture of hectorite and hydroxyethylcellulose.
Claim 3
Dependent Claim 15 words
A composition according to claim 1 containing about 5% salicylic acid and 5% benzoyl peroxide.
Claim 4
Dependent Claim 28 words
A composition according to claim 1 wherein said agent is a mixture of about 2% by weight of magnesium aluminum silicate and about 1.25% by weight of methylcellulose.
Claim 5
Dependent Claim 17 words
A composition according to claim 3 further including about 1% by weight of modified cold process starch.
Claim 6
Dependent Claim 37 words
A composition according to claim 4 further including an amount of a sequestering agent sufficient to sequester metal ions present in the composition which may complex with the salicylic acid and promote decomposition of the benzoyl peroxide.
Claim 7
Dependent Claim 26 words
The composition according to claim 5 wherein the sequestering agent is disodium EDTA or EDTA and is present in an amount of about 0.1% by weight.
Claim 8
Dependent Claim 41 words
A composition according to claim 6 further including about 6% by weight of a compound having the formula CH 3 (CH 2 ) 10 CH 2 (OCH 2 CH 2 ) n OH wherein n has an average value of 4.
Claim 9
Dependent Claim 24 words
A composition according to claim 1 wherein said agent is magnesium aluminum silicate and is present in an amount of about 8% by weight.
Claim 10
Dependent Claim 24 words
A composition according to claim 1 wherein said agent is methylcellulose and is present in an amount of about 3 to 4% by weight.
Claim 11
Dependent Claim 22 words
A composition according to claim 1 wherein said agent is pectin and is present in an amount of about 2% by weight.
Claim 12
Dependent Claim 23 words
A composition according to claim 1 wherein said agent is xanthan gum and is present in an amount of about 3% by weight.
Claim 13
Dependent Claim 31 words
A composition according to claim 1 wherein said agent is polyethylene oxide having an average molecular weight of about 400,000, and is present in an amount of about 5% by weight.
Claim 14
Dependent Claim 31 words
A composition according to claim 1 wherein said agent is polyethylene oxide having an average molecular weight of about 300,000 and is present in an amount of about 6% by weight.
Claim 15
Dependent Claim 31 words
A composition according to claim 1 wherein said agent is polyethylene oxide having an average molecular weight of about 600,000 and is present in an amount of about 6% by weight.
Claim 16
Dependent Claim 22 words
A composition according to claim 1 wherein said agent is polyacrylamide and is present in an amount of about 2% by weight.
Claim 17
Dependent Claim 28 words
A composition according to claim 1 wherein said agent is a 1:1 mixture of hectorite and hydroxyethylcellulose and is present in an amount of about 3% by weight.

References Cited (Backward Citations)

US3530217A Cited
US3535422A Cited
DE2416542A1 Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1985-10-18 1986-04-19 1986-10-19 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1989-10-18 1990-04-19 1990-10-19 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1993-10-18 1994-04-19 1994-10-19 $7700.00 Window Closed / Lapsed

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