Mercaptoacyl derivatives of substituted prolines

Claim 1

A compound of the formula ##STR22## or a basic salt thereof wherein the X--R 1 group is located at the 3- or 4-position of the proline ring; X is oxygen or sulfur; R is hydrogen or lower alkyl; R 1 is lower alkyl, lower alkenyl, lower alkynyl, cycloalkyl, 1- or 2-adamantyl, phenyl, phenyl-lower alkylene, 1- or 2-naphthyl, biphenyl, substituted phenyl, substituted phenyl-lower alkylene, substituted 1- or 2-naphthyl, or substituted biphenyl wherein said substituent is one or two groups on the phenyl ring selected from the group consisting of lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, iodo, trifluoromethyl, acetyloxy, and hydroxy; R 2 and R 3 are independently selected from hydrogen, lower alkyl and trifluoromethyl; R 4 is hydrogen, ##STR23## R 5 is lower alkyl, phenyl, phenyl-lower alkylene, substituted phenyl, or substituted phenyl-lower alkylene wherein said substituent is one or two groups on the phenyl ring selected from the group consisting of lower alkyl of 1 to 4 carbons, lower alkoxy of 1 to 4 carbons, lower alkylthio of 1 to 4 carbons, chloro, bromo, fluoro, iodo, trifluoromethyl, acetyloxy, and hydroxy; and n is 0, 1 or 2.