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US4154935A
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Halogen substituted mercaptoacylamino acids
Assignee: ER Squibb and Sons LLC
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Filing: 1978-09-01
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Granted: 1979-05-15
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Expires: 1998-09-01
Abstract
Abstract New halogen substituted mercaptoacylamino acids which have the general formula ##STR1## ARE USEFUL AS HYPOTENSIVE AGENTS.
Inventors
- 👤 Miguel A. Ondetti
- 👤 Peter W. Sprague
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:58
CPC Classifications
C; C07; C07D; C07D211/00; C07D211/04; C07D211/06; C07D211/36; C07D211/60; C07C; C07C327/00; C07C57/00; C07C57/52; C07D207/00; C07D207/02; C07D207/04; C07D207/10; C07D207/16
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
92 words
A compound of the formula ##STR12## wherein R is hydrogen, lower alkanoyl or ##STR13## m is 2; n is 0 or 1; R 1 is hydrogen or lower alkyl; R 2 and R 2 ' each is hydrogen or halogen; R 3 and R 4 each is hydrogen, lower alkyl or trifluoromethyl, not more than one being trifluoromethyl, and at least one of R 2 , R 2 ', R 3 or R 4 is a halogen or trifluoromethyl substituent represented by the named symbol as defined above; and basic salts thereof.
Claim 2
Dependent Claim
92 words
A compound of the formula ##STR12## wherein R is hydrogen, lower alkanoyl or ##STR13## m is 2; n is 0 or 1; R 1 is hydrogen or lower alkyl; R 2 and R 2 ' each is hydrogen or halogen; R 3 and R 4 each is hydrogen, lower alkyl or trifluoromethyl, not more than one being trifluoromethyl, and at least one of R 2 , R 2 ', R 3 or R 4 is a halogen or trifluoromethyl substituent represented by the named symbol as defined above; and basic salts thereof.
Claim 3
Dependent Claim
60 words
A compound as in claim 1 wherein n is 0 or 1; R is hydrogen or lower alkanoyl; R 1 is hydrogen or lower alkyl; R 2 and R 2 ' is hydrogen or halogen; R 3 is trifluoromethyl when n is 0, either R 3 or R 4 is trifluoromethyl and the other is hydrogen when n is 1.
Claim 4
Dependent Claim
25 words
A compound as in claim 1 wherein R, R 2 , R 2 ' and R 4 all are hydrogen and R 3 is trifluoromethyl.
Claim 5
Dependent Claim
25 words
A compound as in claim 1 wherein R, R 2 , R 2 ' and R 3 all are hydrogen and R 4 is trifluoromethyl.
Claim 6
Dependent Claim
17 words
A compound as in claim 1 wherein R 2 is halogen and R 2 ' is hydrogen.
Claim 7
Dependent Claim
11 words
A compound as in claim 5 wherein the halogen is fluorine.
Claim 8
Dependent Claim
20 words
A compound as in claim 1 wherein R is hydrogen and R 2 and R 2 ' each is halogen.
Claim 9
Dependent Claim
11 words
A compound as in claim 7 wherein the halogen is fluorine.
Claim 10
Dependent Claim
15 words
A compound as in claim 1 wherein R 1 is hydrogen and n is 1.
Claim 11
Dependent Claim
27 words
A compound as in claim 1 wherein R and R 1 each is hydrogen, R 2 and R 2 ' each is fluorine and n is 1.
Claim 12
Dependent Claim
28 words
A compound as in claim 1 wherein R, R 1 , R 2 and R 2 ' each is hydrogen, R 3 is trifluoromethyl and n is 0.
Claim 13
Dependent Claim
31 words
A compound as in claim 1 wherein R, R 1 , R 2 , R 2 ' and R 4 each is hydrogen, R 3 is trifluoromethyl and n is 1.
Claim 14
Dependent Claim
28 words
A compound as in claim 1 wherein R, R 1 , R 2 and R 2 ' each is hydrogen, R 3 is trifluoromethyl and n is 0.
Claim 15
Dependent Claim
31 words
A compound as in claim 1 wherein R, R 1 , R 2 , R 2 ' and R 3 each is hydrogen, R 4 is trifluoromethyl and n is 1.
Claim 16
Dependent Claim
10 words
A compound as in claim 1 wherein R is ##STR14##
Claim 17
Dependent Claim
33 words
A compound as in claim 1 wherein R, R 1 and R 4 each is hydrogen, R 2 and R 2 ' each is fluorine, R 3 is trifluoromethyl and n is 1.
Claim 18
Dependent Claim
34 words
A compound as in claim 15 wherein each R 1 and R 4 is hydrogen; each R 2 and R 2 ' is fluorine, each R 3 is trifluoromethyl, and each n is 1.
Claim 19
Dependent Claim
33 words
A compound as in claim 1 wherein R, R 1 and R 2 each is hydrogen; R 2 ' is fluorine; R 3 is methyl; R 4 is hydrogen and n is 1.
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-05-14 | 1982-11-13 | 1983-05-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-05-14 | 1986-11-13 | 1987-05-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-05-14 | 1990-11-13 | 1991-05-15 | $7700.00 | Window Closed / Lapsed |