Patent US4307111A successfully refreshed from Google Patents.
US4307111A
Expired / Lapsed
US
⏱️ 0.0 years remaining
1-Hydrocarbyloxyphenyl-1,2-diphenylalkene derivatives
Assignee: Imperial Chemical Industries Ltd
•
Filing: 1980-04-29
•
Granted: 1981-12-22
•
Expires: 2000-04-29
Abstract
Abstract Triphenylalkene derivatives of the formula: <IMAGE> wherein R1 is alkenyl, cycloalkenyl, cycloalkenylalkyl, halogenoalkenyl, hydroxyalkyl, dihydroxyalkyl, hydroxycycloalkyl, dihydroxycycloalkyl, hydroxycycloalkylalkyl, epoxyalkyl, alkoxyalkyl or alkylthioalkyl each of up to 10 carbon atoms, wherein R2 is alkyl of up to 6 carbon atoms, halogen or nitro and wherein ring A may optionally bear a halogen substituent or an alkoxy substituent of up to 4 carbon atoms. These compounds possess antioestrogenic activity and are useful in the treatment of anovulatory infertility and of breast tumours. Representative of the compounds is 1-p-allyloxyphenyl-trans-1,2-diphenylbut-2-ene. There are also disclosed processes for the manufacture of the compounds and pharmaceutical compositions containing them.
Inventors
- 👤 Graham C. Crawley
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:04
CPC Classifications
C; C07; C07D; C07D303/00; C07D303/02; C07D303/12; C07D303/18; C07D303/20; C07D303/22; A; A61; A61P; A61P25/00; A61P25/04; C07C; C07C323/00; C07C43/00; C07C43/02; C07C43/18; C07C43/196; C07C43/20; C07C43/215; C07C43/225; C07C43/23
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
56 words
A triphenylalkene derivative of the formula: ##STR8## wherein R 1 is alkenyl, cycloalkenyl, cycloalkenylalkyl, halogenoalkenyl, hydroxyalkyl, dihydroxyalkyl, hydroxycycloalkyl, dihydroxycycloalkyl, hydroxycycloalkylalkyl or epoxyalkyl, wherein R 2 is alkyl of up to 6 carbon atoms, halogen or nitro and wherein ring A may optionally bear a halogen substituent or an alkoxy substituent of up to 4 carbon atoms.
Claim 2
Dependent Claim
56 words
A triphenylalkene derivative of the formula: ##STR8## wherein R 1 is alkenyl, cycloalkenyl, cycloalkenylalkyl, halogenoalkenyl, hydroxyalkyl, dihydroxyalkyl, hydroxycycloalkyl, dihydroxycycloalkyl, hydroxycycloalkylalkyl or epoxyalkyl, wherein R 2 is alkyl of up to 6 carbon atoms, halogen or nitro and wherein ring A may optionally bear a halogen substituent or an alkoxy substituent of up to 4 carbon atoms.
Claim 3
Dependent Claim
46 words
A triphenylalkene derivative as claimed in claim 1 which has the trans-configuration, wherein R 1 is alkenyl, dihydroxyalkyl or epoxyalkyl each of 3 or 4 carbon atoms, wherein R 2 is alkyl of up to 6 carbon atoms and wherein ring A bears no further substituent.
Claim 4
Dependent Claim
13 words
A triphenylalkene derivative as claimd in claim 2 wherein R 2 is ethyl.
Claim 5
Dependent Claim
7 words
The compound 1-p-allyloxyphenyl-trans-1,2-diphenyl-but-1-ene, 1-p-(2,3-dihydroxypropoxy)phenyl-trans-1,2-diphenyl-but-1-ene, 1-p-(2,3-epoxypropoxy)phenyl-trans-1,2-diphenylbut-1-ene or 1-p-(2,3-dihydroxybutoxy)phenyl-trans-1,2-diphenylbut-1ene.
Claim 6
Dependent Claim
7 words
The compound 1-p-allyloxyphenyl-trans-1,2-diphenyl-but-1-ene, 1-p-(2,3-dihydroxypropoxy)phenyl-trans-1,2-diphenyl-but-1-ene, 1-p-(2,3-epoxypropoxy)phenyl-trans-1,2-diphenylbut-1-ene or 1-p-(2,3-dihydroxybutoxy)phenyl-trans-1,2-diphenylbut-1ene.
Claim 7
Dependent Claim
10 words
A compound according to claim 1, said compound being 1-p-allyloxyphenyl-trans-1,2-diphenyl-but-1-ene.
Claim 8
Dependent Claim
22 words
A pharmaceutical composition having antioestrogenic activity which comprises a triphenylalkene derivative, claimed in claim 1, together with a pharmaceutically-acceptable diluent or carrier.
Claim 9
Dependent Claim
28 words
A method for producing an antioestrogenic effect in a warm-blooded animal which comprises administering to said animal an effective amount of a triphenylalkene derivative claimed in claim 1.
References Cited (Backward Citations)
US2301260A
Cited
US2346049A
Cited
GB567807A
Cited
GB586493A
Cited
US3320271A
Cited
US3875242A
Cited
US3712929A
Cited
US3947520A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-12-21 | 1985-06-22 | 1985-12-22 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-12-21 | 1989-06-22 | 1989-12-22 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-12-21 | 1993-06-22 | 1993-12-22 | $7700.00 | Window Closed / Lapsed |