US4306568A — Method and apparatus for congelation cryometry in…

Claim 1

Independent Claim 100 words

In the cryocongelation of malignant tissue, the improvement which comprises monitoring the temperature of the tissue to be frozen by inserting an active needle electrode laterally of and below a tumor to be treated, applying an indifferent electrode to the patient's skin at a point displaced from said tumor, applying a low voltage D.C. potential across said electrodes to pass a current of less than 20 microamperes between said electrodes, and measuring the decrease of current during freezing to determine the temperature of the tissue at the base of the tumor and to thereby monitor the degree of cryocongelation thereof.

Claim 2

Dependent Claim 100 words

In the cryocongelation of malignant tissue, the improvement which comprises monitoring the temperature of the tissue to be frozen by inserting an active needle electrode laterally of and below a tumor to be treated, applying an indifferent electrode to the patient's skin at a point displaced from said tumor, applying a low voltage D.C. potential across said electrodes to pass a current of less than 20 microamperes between said electrodes, and measuring the decrease of current during freezing to determine the temperature of the tissue at the base of the tumor and to thereby monitor the degree of cryocongelation thereof.

Claim 3

Dependent Claim 55 words

The method of claim 1, in which the decrease of current during freezing is monitored to a current value of no more than five microamperes which is equivalent to a temperature in the tissue adjacent the active needle electrode of no more than -22° to -25° C., below the eutectic point for common cellular electrolytes.

Claim 4

Dependent Claim 55 words

The method of claim 1, in which the decrease of current during freezing is monitored to a current value of no more than one microampere which is equivalent to a temperature in the tissue adjacent the active needle electrode of no more than -40° to -60° C., below the eutectic point for all cellular electrolytes.

Claim 5

Dependent Claim 49 words

The method of claim 1, wherein the active needle electrode comprises a flexible straight wire electrode and in which said wire electrode is inserted adjacent the tumor and so angled as to avoid penetration thereof, the point of the needle lying directly below the central portion of the tumor.

Claim 6

Dependent Claim 66 words

The method of claim 1, wherein the active needle electrode possesses a generally concave curvature and in which said needle electrode is so inserted adjacent the tumor as to pass thereunder to cradle the same, the point of the needle electrode extending outwardly from the skin at a point adjacent the side of the tumor remote from that adjacent the point of insertion of said electrode.

Claim 7

Independent Claim 133 words

An apparatus for measuring the degree of cryocongelation of malignant tissue, which comprises a plurality of independently movable active needle electrodes for subcutaneous insertion laterally of and below a tissue to be treated at different points spaced about the periphery thereof without invading said tissue, an indifferent electrode for application to the patient's skin at a point displaced from said tissue, a low voltage D.C. power source in circuit with said electrodes, having a pair of output terminals, circuit means for simultaneously connecting said plurality of active electrodes to one of said output terminals, circuit means for connecting said indifferent electrode to the other of said output terminals, current regulating means for producing a current in said circuit of less than 20 microamperes, and meter means in said circuit for monitoring said current.

Claim 8

Independent Claim 133 words

An apparatus for measuring the degree of cryocongelation of malignant tissue, which comprises a plurality of independently movable active needle electrodes for subcutaneous insertion laterally of and below a tissue to be treated at different points spaced about the periphery thereof without invading said tissue, an indifferent electrode for application to the patient's skin at a point displaced from said tissue, a low voltage D.C. power source in circuit with said electrodes, having a pair of output terminals, circuit means for simultaneously connecting said plurality of active electrodes to one of said output terminals, circuit means for connecting said indifferent electrode to the other of said output terminals, current regulating means for producing a current in said circuit of less than 20 microamperes, and meter means in said circuit for monitoring said current.

Claim 9

Independent Claim 83 words

An apparatus for measuring the degree of cryocongelation of maligant tissue, which comprises a flexible straight wire electrode for non-malignant tissue invasive insertion adjacent and under the tumor to be cryocongelated, an indifferent electrode for application to the patient's skin at a point displaced from such tissue, a low voltage D.C. power source in circuit with said electrodes, current regulating means for producing a current in said circuit of less than 20 microamperes, and meter means in said circuit for monitoring said current.

Claim 10

Independent Claim 83 words

An apparatus for measuring the degree of cryocongelation of maligant tissue, which comprises a flexible straight wire electrode for non-malignant tissue invasive insertion adjacent and under the tumor to be cryocongelated, an indifferent electrode for application to the patient's skin at a point displaced from such tissue, a low voltage D.C. power source in circuit with said electrodes, current regulating means for producing a current in said circuit of less than 20 microamperes, and meter means in said circuit for monitoring said current.

Claim 11

Independent Claim 90 words

An apparatus for measuring the degree of cryocongelation of malignant tissue, which comprises an active needle electrode possessing a generally concave curvature for inserting peripherally of and under the tissue to be cryocongelated without invading the malignant tissue, an indifferent electrode for application to the patient's skin at a point displaced from said tissue, a low voltage D.C. power source in circuit with said electrodes, current regulating means for producing a current in said circuit of less than 20 microamperes, and meter means in said circuit for monitoring said current.

Claim 12

Independent Claim 90 words

An apparatus for measuring the degree of cryocongelation of malignant tissue, which comprises an active needle electrode possessing a generally concave curvature for inserting peripherally of and under the tissue to be cryocongelated without invading the malignant tissue, an indifferent electrode for application to the patient's skin at a point displaced from said tissue, a low voltage D.C. power source in circuit with said electrodes, current regulating means for producing a current in said circuit of less than 20 microamperes, and meter means in said circuit for monitoring said current.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1984-12-21	1985-06-22	1985-12-22	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1988-12-21	1989-06-22	1989-12-22	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1992-12-21	1993-06-22	1993-12-22	$7700.00	Window Closed / Lapsed

Method and apparatus for congelation cryometry in cryosurgery

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