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US4140109A
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Impedance-based method and apparatus for monitoring cryodestruction in controlled cryosurgery
Assignee: Frigitronics Inc
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Filing: 1977-10-17
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Granted: 1979-02-20
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Expires: 1997-10-17
Abstract
Abstract An impedance-based method for the controlled cryosurgery of a patient's malignant tumor consisting of the steps: placing a contact electrode electrically connected to an impedance meter in electric contact with a body site spaced away from the tumor target, inserting a needle electrode electrically connected to the impedance meter through the tumor target with the tip of the needle electrode penetrating the immediately underlying normal tissue therebelow, and monitoring during cryosurgery the impedance between the two electrodes as a reflection of the eutectic state of the tissue circumadjacent the tip of the needle electrode.
Inventors
- 👤 Michael I. Savic
- 👤 Setrag A. Zacarian
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 23:47
CPC Classifications
A; A61; A61B; A61B18/00; A61B18/02; A61B5/00; A61B5/05; A61B5/053; A61B5/0538; A61B17/00; A61B2017/00017; A61B2017/00022; A61B2017/00026
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
94 words
An impedance-based method for the controlled cryosurgery of a patient's malignant tumor consisting of the steps: placing a contact electrode electrically connected to an impedance meter in electric contact with a body site spaced away from the tumor target, inserting a needle electrode electrically connected to the impedance meter through the tumor target with the tip of the needle electrode penetrating the immediately underlying normal tissue therebelow, and monitoring during cryosurgery the impedance between the two electrodes as a reflection of the eutectic state of the tissue circumadjacent the tip of the needle electrode.
Claim 2
Dependent Claim
94 words
An impedance-based method for the controlled cryosurgery of a patient's malignant tumor consisting of the steps: placing a contact electrode electrically connected to an impedance meter in electric contact with a body site spaced away from the tumor target, inserting a needle electrode electrically connected to the impedance meter through the tumor target with the tip of the needle electrode penetrating the immediately underlying normal tissue therebelow, and monitoring during cryosurgery the impedance between the two electrodes as a reflection of the eutectic state of the tissue circumadjacent the tip of the needle electrode.
Claim 3
Dependent Claim
26 words
The method as set forth in claim 1, with the dominant impedance within the circuit being the impedance between the needle electrode tip and circumadjacent tissue.
Claim 4
Dependent Claim
34 words
The method as set forth in claim 1, with the impedance between the needle electrode tip and circumadjacent tissue being the dominant impedance among the plurality of impedances connected in series in the circuitry.
Claim 5
Dependent Claim
25 words
In the method as set forth in claim 1, the monitoring being conducted in seriatim at a plurality of selected sites of the tumor target.
Claim 6
Dependent Claim
40 words
In the method as set forth in claim 1, including the step of terminating the lethal freezing of the neoplasm at its eutectic state as indicated by a visual signal generated upon attainment of a high value of the impedance.
Claim 7
Dependent Claim
38 words
In the method as set forth in claim 1, including the step of terminating the cryodestructive procedure at the critical end point as indicated by an auditory signal generated upon attainment of a high value of the impedance.
Claim 8
Dependent Claim
35 words
In the method as set forth in claim 1 including the step of determining the depth of insertion of the needle electrode and depth of cryodestruction as reflected by the calibrations on the needle electrode.
Claim 9
Dependent Claim
101 words
Apparatus for monitoring the moment when a patient's malignant tumor reaches the eutectic state comprising in an electrical circuit: an impedance meter, a needle electrode electrically connected to the impedance meter, and a contact electrode electrically connected to the impedance meter, with the impedance meter indicating a measurement of the impedance between the electrodes as a reflection of the cryodestructive condition of the frozen tissue circumadjacent the needle electrode tip upon insertion through the tumor and into the underlying normal marginal tissue therebelow and with the contact electrode being in electric contact with a body site spaced away from the tumor.
Claim 10
Dependent Claim
101 words
Apparatus for monitoring the moment when a patient's malignant tumor reaches the eutectic state comprising in an electrical circuit: an impedance meter, a needle electrode electrically connected to the impedance meter, and a contact electrode electrically connected to the impedance meter, with the impedance meter indicating a measurement of the impedance between the electrodes as a reflection of the cryodestructive condition of the frozen tissue circumadjacent the needle electrode tip upon insertion through the tumor and into the underlying normal marginal tissue therebelow and with the contact electrode being in electric contact with a body site spaced away from the tumor.
Claim 11
Dependent Claim
28 words
In the apparatus as set forth in claim 8, including auditory signal means for generating an auditory signal by the attainment of a high value of the impedance.
Claim 12
Dependent Claim
28 words
In the apparatus as set forth in claim 8, including visual signal means for generating a visual signal by the attainment of a high value of the impedance.
Claim 13
Dependent Claim
40 words
In the apparatus as set forth in claim 8, including calibrations on the needle electrode for determining the depth of insertion of the needle electrode and accordingly the depth of the destruction by reading the calibrations on the needle electrode.
Claim 14
Dependent Claim
116 words
Apparatus for monitoring the moment when a patient's malignant tumor reaches the eutectic state cmprising in an electrical circuit: a plurality of needle electrodes for insertion into and through different sites in the target area, a contact electrode for placement in electrical contact with a body site outside of the target area, an impedance meter for measuring the impedance between the needle electrodes and contact electrode as a reflection of the cryodestructive condition of the frozen tissue circumadjacent each of the needle electrode tips, circuitry between the needle electrodes and contact electrode and impedance meter, and a switch for alternately and selectively connecting one of the needle electrodes of the plurality thereof to the impedance meter.
Claim 15
Dependent Claim
116 words
Apparatus for monitoring the moment when a patient's malignant tumor reaches the eutectic state cmprising in an electrical circuit: a plurality of needle electrodes for insertion into and through different sites in the target area, a contact electrode for placement in electrical contact with a body site outside of the target area, an impedance meter for measuring the impedance between the needle electrodes and contact electrode as a reflection of the cryodestructive condition of the frozen tissue circumadjacent each of the needle electrode tips, circuitry between the needle electrodes and contact electrode and impedance meter, and a switch for alternately and selectively connecting one of the needle electrodes of the plurality thereof to the impedance meter.
Claim 16
Dependent Claim
111 words
Apparatus for monitoring and recording the monitoring of the correlation between the temperature of the tissue circumadjacent the tip of a needle electrode inserted into and through a malignant tumor and the impedance between the needle electrode tip and circumadjacent tissue comprising: an impedance meter, a thermocouple needle electrode for insertion into and through the target area and being electrically connected to the impedance meter, a contact electrode for contacting with the patient's body at a point away from the target area and being electrically connected to the impedance meter, and a recorder for recording the measured temperature at the target area and the simultaneously measured impedance at the target area.
Claim 17
Dependent Claim
111 words
Apparatus for monitoring and recording the monitoring of the correlation between the temperature of the tissue circumadjacent the tip of a needle electrode inserted into and through a malignant tumor and the impedance between the needle electrode tip and circumadjacent tissue comprising: an impedance meter, a thermocouple needle electrode for insertion into and through the target area and being electrically connected to the impedance meter, a contact electrode for contacting with the patient's body at a point away from the target area and being electrically connected to the impedance meter, and a recorder for recording the measured temperature at the target area and the simultaneously measured impedance at the target area.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-19 | 1982-08-21 | 1983-02-20 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-19 | 1986-08-21 | 1987-02-20 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-19 | 1990-08-21 | 1991-02-20 | $7700.00 | Window Closed / Lapsed |