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US4301118A Expired / Lapsed US ⏱️ 0.0 years remaining

Protein concentrator

Assignee: Spectrum Medical Industries Inc
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Filing: 1980-03-06
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Granted: 1981-11-17
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Expires: 2000-03-06
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Abstract

Abstract A protein concentrator having a reservoir for holding a protein solution and a membrane positioned within the protein solution through which a portion of the solution passes. The membrane is held in the walls of a container assembly and a water soluble polymer is located on one side of the membrane to increase the concentration gradient through the membrane for concentrating the solution.

Inventors

  • 👤 Roy T. Eddleman
  • 👤 Gregory F. Moran

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 14:21
CPC Classifications
G; G01; G01N; G01N27/00; G01N27/26; G01N27/28; G01N27/40; B; B01; B01D; B01D61/00; B01D61/24; B01D61/28; Y; Y10; Y10S; Y10S210/00; Y10S210/902; Y10S210/903; Y10S210/905; Y10T; Y10T436/00; Y10T436/25; Y10T436/25375; Y10T436/255

Claims Analysis

Total Claims: 12
Claim 1
Independent Claim 239 words
A protein concentrator, comprising: means defining a reservoir for holding a protein solution; a cover assembly held within said reservoir; a semi-permeable membrane member having openings large enough to permit passage of water but having a molecule weight cut-off sufficient to prohibit the passage of at least some of the consituents of a protein solution, said membrane member being supported by said cover assembly and forming a tubular container positioned within the reservoir so that a protein solution held within the reservoir will contact the outer surface of the semi-permeable member and the inner surface of the semi-permeable member will not be exposed to the contents of the reservoir, the semi-permeable member being sealed to the container to prevent any portion of the protein solution from passing to the interior of the container without passing through the member; and a water soluble polymeric powder held within said membrane, said polymeric powder having a molecular size so that it will not pass through the semi-permeable membrane member, whereby when a protein solution is placed in the reservoir, the protein solution will contact the exterior surface of the semi-permeable membrane and a portion of the protein solution will pass through the membrane and dissolve a portion of the water soluble polymeric powder creating a concentration gradient across the membrane to increase the flux of the solution through the membrane and into the container thereby concentrating the protein solution in the reservoir.
Claim 2
Dependent Claim 239 words
A protein concentrator, comprising: means defining a reservoir for holding a protein solution; a cover assembly held within said reservoir; a semi-permeable membrane member having openings large enough to permit passage of water but having a molecule weight cut-off sufficient to prohibit the passage of at least some of the consituents of a protein solution, said membrane member being supported by said cover assembly and forming a tubular container positioned within the reservoir so that a protein solution held within the reservoir will contact the outer surface of the semi-permeable member and the inner surface of the semi-permeable member will not be exposed to the contents of the reservoir, the semi-permeable member being sealed to the container to prevent any portion of the protein solution from passing to the interior of the container without passing through the member; and a water soluble polymeric powder held within said membrane, said polymeric powder having a molecular size so that it will not pass through the semi-permeable membrane member, whereby when a protein solution is placed in the reservoir, the protein solution will contact the exterior surface of the semi-permeable membrane and a portion of the protein solution will pass through the membrane and dissolve a portion of the water soluble polymeric powder creating a concentration gradient across the membrane to increase the flux of the solution through the membrane and into the container thereby concentrating the protein solution in the reservoir.
Claim 3
Dependent Claim 11 words
The protein concentrator of claim 1 wherein said reservoir is cylindrical.
Claim 4
Dependent Claim 14 words
The protein concentrator of claim 1 wherein said container and said reservoir are cylindrical.
Claim 5
Dependent Claim 26 words
The protein concentrator of claim 1 wherein the lower cylindrical member about touches the bottom of the reservoir when the container is placed in said reservoir.
Claim 6
Dependent Claim 19 words
The protein concentrator of claim 4 wherein the container displaces at least 50% of the interior of the reservoir.
Claim 7
Dependent Claim 44 words
The protein concentrator of claim 1 wherein the container comprises a lower cylinder and an upper cylinder held apart by a finger member and the semi-permeable membrane comprises a tubular sleeve surrounding at least a portion of the upper cylinder and the lower cylinder.
Claim 8
Dependent Claim 33 words
The protein concentrator of claim 6 wherein the lower cylinder has an annular groove in the exterior surface thereof and the semi-permeable membrane member is held to the lower cylinder by an O-ring.
Claim 9
Dependent Claim 34 words
The protein concentrator of claim 6 wherein the upper cylinder has an annular groove in the exterior surface thereof and the semi-permeable membrane member is held to the upper cylinder member by an O-ring.
Claim 10
Dependent Claim 18 words
The protein concentrator of claim 1 wherein said semi-permeable membrane in a tubular member made from regenerated cellulose.
Claim 11
Dependent Claim 17 words
The protein concentrator of claim 1 wherein said water soluble polymer is a non-ionic water soluble polymer.
Claim 12
Dependent Claim 14 words
The protein concentrator of claim 1 wherein said water soluble polymer is polyvinyl pyrrilidone.

References Cited (Backward Citations)

US3414131A Cited
US3969250A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1984-11-16 1985-05-18 1985-11-17 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1988-11-16 1989-05-18 1989-11-17 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1992-11-16 1993-05-18 1993-11-17 $7700.00 Window Closed / Lapsed

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