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US4243671A
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Inhibition of thromboxane synthetase formation and arachidonic acid-induced platelet aggregation and bronchoconstriction
Assignee: ER Squibb and Sons LLC
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Filing: 1979-04-16
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Granted: 1981-01-06
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Expires: 1999-04-16
Abstract
Abstract 1-(3-Phenyl-2-propenyl)-1H-imidazole, and its hydrochloride salt have been found to be potent inhibitor of thromboxane synthetase and therefore an inhibitor of arachidonic acid-induced platelet aggregation and bronchoconstriction.
Inventors
- 👤 Don N. Harris
- 👤 Marie B. Phillips
- 👤 Roland Greenberg
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:30
CPC Classifications
A; A61; A61K; A61K31/00; A61K31/33; A61K31/395; A61K31/41; A61K31/415
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
43 words
A method of inhibiting thromboxane synthetase activity, and thus inhibiting arachidonic acid-induced platelet aggregation and broncho-constriction, which comprises administering to the circulatory system of a mammalian host in need thereof an effective amount of 1-(3-phenyl-2-propenyl)-1H-imidazole or a pharmaceutically acceptable acid addition salt thereof.
Claim 2
Independent Claim
43 words
A method of inhibiting thromboxane synthetase activity, and thus inhibiting arachidonic acid-induced platelet aggregation and broncho-constriction, which comprises administering to the circulatory system of a mammalian host in need thereof an effective amount of 1-(3-phenyl-2-propenyl)-1H-imidazole or a pharmaceutically acceptable acid addition salt thereof.
Claim 3
Dependent Claim
26 words
The method as defined in claim 1 wherein said 1-(3-phenyl-2-propenyl)-1H-imidazole is administered in an amount within the range of from about 1 to about 100 mg/kg.
Claim 4
Dependent Claim
18 words
The method as defined in claim 1 wherein said imidazole is in the form of its hydrochloride salt.
Claim 5
Independent Claim
31 words
A method of inhibiting arachidonic acid-induced platelet aggregation which comprises administering to a mammalian host in need thereof an effective amount of 1-(3-phenyl-2-propenyl)-1H-imidazole or a pharmaceutically acceptable acid addition salt thereof.
Claim 6
Independent Claim
31 words
A method of inhibiting arachidonic acid-induced platelet aggregation which comprises administering to a mammalian host in need thereof an effective amount of 1-(3-phenyl-2-propenyl)-1H-imidazole or a pharmaceutically acceptable acid addition salt thereof.
Claim 7
Dependent Claim
18 words
The method as defined in claim 4 wherein said imidazole is in the form of its hydrochloride salt.
Claim 8
Independent Claim
33 words
A method of inhibiting arachidonic acid-induced bronchoconstriction associated with asthma, whch comprises administering to a mammalian host in need thereof an effect amount of 1-(3-phenyl-2-propenyl)-1H-imidazole or a pharmaceutically acceptable acid addition salt thereof.
Claim 9
Independent Claim
33 words
A method of inhibiting arachidonic acid-induced bronchoconstriction associated with asthma, whch comprises administering to a mammalian host in need thereof an effect amount of 1-(3-phenyl-2-propenyl)-1H-imidazole or a pharmaceutically acceptable acid addition salt thereof.
Claim 10
Dependent Claim
18 words
The method as defined in claim 6 wherein said imidazole is in the form of its hydrochloride salt.
References Cited (Backward Citations)
No citation records indexed.
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1984-01-06 | 1984-07-07 | 1985-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1988-01-06 | 1988-07-07 | 1989-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1992-01-06 | 1992-07-07 | 1993-01-06 | $7700.00 | Window Closed / Lapsed |