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US4239743A
Expired / Lapsed
US
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Carrier-bound immunoglobulin fission product and its use in immunologic analyses
Assignee: Siemens Healthcare Diagnostics GmbH Germany
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Filing: 1978-07-13
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Granted: 1980-12-16
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Expires: 1998-07-13
Abstract
Abstract A fission product of an immunoglobulin having an immunologically functioning Fc-portion is bound to a carrier by adhesion or a chemical reaction. It can be used in an immunological analytic process for the determination of Fc-reactants in aqueous solutions.
Inventors
- 👤 Hans H. Sedlacek
- 👤 Friedrich R. Seiler
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:30
CPC Classifications
C; C07; C07K; C07K16/00; G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/53; G01N33/563; Y; Y10; Y10S; Y10S436/00; Y10S436/804; Y10S530/00; Y10S530/866; Y10S530/868
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
26 words
An Fc-sensitive reagent consisting essentially of an immunoglobulin fission product having an immunologically-functioning Fc-portion, said product being bound to a carrier by adhesion or chemical reaction.
Claim 2
Dependent Claim
26 words
An Fc-sensitive reagent consisting essentially of an immunoglobulin fission product having an immunologically-functioning Fc-portion, said product being bound to a carrier by adhesion or chemical reaction.
Claim 3
Dependent Claim
15 words
An Fc-sensitive reagent as in claim 1 wherein said carrier is an optically-clear shaped structure.
Claim 4
Dependent Claim
22 words
An Fc-sensitive reagent as in claim 1 wherein said immunoglobulin fission product having an immunologically-functioning Fc-portion is the Fc-fragment of immunoglobulin G.
Claim 5
Dependent Claim
59 words
A method for determining an Fc-reactant, which method comprises contacting a liquid containing said Fc-reactant with an Fc-sensitive reagent as in claim 1, separating the carrier from the liquid, reacting the Fc-reactant bound to the carrier with an antibody reacting with said Fc-reactant but not capable of undergoing a cross-reaction with said immunoglobulin fission product, and determining the antibody.
Claim 6
Dependent Claim
34 words
A method as in claim 4 wherein the antibody reacting with said Fc-reactant is labelled and the amount of labelling agent bound to the carrier or the amount of free labelling agent is determined.
Claim 7
Dependent Claim
24 words
A method as in claim 4 wherein the said Fc-reactant is RF, C1 q , or an antibody against immunoglobulin immunologically-modified in the Fc-part.
Claim 8
Dependent Claim
23 words
A method as in claim 4 wherein said Fc-reactant is RF and the antibody used is directed against L-chains or Fab-fragments of immunoglobulins.
Claim 9
Dependent Claim
22 words
A method as in claim 4 wherein said Fc-reactant is C1 q and the antibody used is directed against C1 q .
Claim 10
Dependent Claim
23 words
A method as in claim 3 wherein said Fc-reactant is C 3 d and the antibody used is directed against C 3 d.
Claim 11
Dependent Claim
53 words
A method for the determination of immunologically-modified immunoglobulin, which method comprises adding an Fc-reactant to a liquid containing the substance to be determined, said Fc-reactant being in excess, contacting the resulting liquid with an Fc-sensitive reactant as in claim 1, separating the carrier from the liquid, and determining the free or bound Fc-reactant.
Claim 12
Dependent Claim
23 words
A method as in claim 10 wherein said Fc-reactant is RF, C1 q , or an antibody against immunoglobulin immunologically-modified in the Fc-part.
Claim 13
Dependent Claim
17 words
A method as in claim 10 wherein said Fc-reactant is labelled and the labelling agent is determined.
Claim 14
Dependent Claim
59 words
A method as in claim 10 wherein said Fc-sensitive reagent, having the Fc-reactant bound thereto, is contacted with a labelled antibody directed against the antigenic determinants of said Fc-reactant and not capable of cross-reacting with the immunoglobulin fission product bound to the carrier, and the free labelling agent or the labelling agent bound to the carrier is then determined.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-12-16 | 1984-06-16 | 1984-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-12-16 | 1988-06-16 | 1988-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-12-16 | 1992-06-16 | 1992-12-16 | $7700.00 | Window Closed / Lapsed |