Patent US4235725A successfully refreshed from Google Patents.
US4235725A
Expired / Lapsed
US
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Sterile blood-collecting and separating device
Assignee: Kimble Asset Management Inc
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Filing: 1978-08-16
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Granted: 1980-11-25
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Expires: 1998-08-16
Abstract
Abstract A pre-packaged blood collecting and separating device and process of its preparation are disclosed in which the device contains a mixture of liquid polybutadiene and an inorganic, inert filler, such as silica, as a thixotropic gel adapted at rest to form a sealing barrier between separated blood phases. The device and gel are subjected to sterilizing radiation to form a substantially sterile device, substantially free of backflow contamination, without degradation of the physical properties of the gel.
Inventors
- 👤 Frank E. Semersky
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:57
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/483; G01N33/487; G01N33/49; G01N33/491; B; B01; B01D; B01D17/00; B01D17/02; B01D17/0217; B01D17/04; B01D17/047; B01D43/00
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
116 words
In a substantially sterile, irradiated, blood collecting and separating device comprising an enclosed container adapted to receive a blood sample and having therein a thixotropic gel adapted to form a separating barrier between separated phases of said blood having differing densities, said gel having at rest a density intermediate said differing densities; the improvement wherein said gel comprises a sterilizing irradiated liquid polybutadiene still retaining carbon-to-carbon unsaturation and an inorganic inert filler dispersed therein, said gel having been subjected to sterilizing radiation without substantial loss of said carbon-to-carbon unsaturation in said butadiene, whereby said container and gel are sterilized to provide said sterile blood collecting and separating device without destruction of physical properties of said gel.
Claim 2
Dependent Claim
116 words
In a substantially sterile, irradiated, blood collecting and separating device comprising an enclosed container adapted to receive a blood sample and having therein a thixotropic gel adapted to form a separating barrier between separated phases of said blood having differing densities, said gel having at rest a density intermediate said differing densities; the improvement wherein said gel comprises a sterilizing irradiated liquid polybutadiene still retaining carbon-to-carbon unsaturation and an inorganic inert filler dispersed therein, said gel having been subjected to sterilizing radiation without substantial loss of said carbon-to-carbon unsaturation in said butadiene, whereby said container and gel are sterilized to provide said sterile blood collecting and separating device without destruction of physical properties of said gel.
Claim 3
Dependent Claim
39 words
The blood collecting and separating device of claim 1 in which said container comprises an open-ended tube adapted for centrifuging, said open-end being closed by an elastomeric, self-sealing plug adapted to be penetrated by a needle or the like.
Claim 4
Dependent Claim
25 words
The blood collecting and separating device of claim 1 in which said filler is selected from the group consisting of silica, bentonite, alumina, and talc.
Claim 5
Dependent Claim
16 words
The blood collecting and separating device of claim 1 in which said filler is fumed silica.
Claim 6
Dependent Claim
26 words
The blood collecting and separating device of claim 1 in which said filler is present in an amount to impart a desired density to said composition.
Claim 7
Dependent Claim
16 words
The blood collecting and separating device of claim 1 in which said container is partially evacuated.
Claim 8
Dependent Claim
34 words
The blood collecting and separating device of claim 1 in which said gel comprises about 100 parts by weight of liquid polybutadiene and about 20 to about 60 parts by weight of said filler.
Claim 9
Dependent Claim
32 words
The blood collecting and separating device of claim 1 in which said gel comprises about 100 parts by weight of liquid polybutadiene and about 30 to about 40 parts of fumed silica.
Claim 10
Dependent Claim
73 words
The blood collecting and separating device of claim 1 in which said liquid butadiene is selected from the group consisting of a polymer of: ##STR3## and a copolymer of said reactant with a second reactant comprising: ##STR4## said second reactant being optionally present in an amount up to about 25% by weight of said first mentioned reactant, and the value of n in all cases being sufficiently low to impart the liquid state.
Claim 11
Dependent Claim
93 words
A process for preparing a pre-packaged, substantially sterile, blood collecting and separating device substantially free of backflow contamination, comprising: (a) placing within a container a quantity of a thixotropic gel sufficient to form at rest a separating barrier extending across the container, said gel comprising liquid polybutadiene and an inorganic inert filler dispersed therein, (b) forming a partial vacuum in said container and enclosing the partially evacuated container, and (c) subjecting the container and thixotropic gel to sterilizing radiation to form a substantially sterile device without degradating the physical properties of said gel.
Claim 12
Dependent Claim
93 words
A process for preparing a pre-packaged, substantially sterile, blood collecting and separating device substantially free of backflow contamination, comprising: (a) placing within a container a quantity of a thixotropic gel sufficient to form at rest a separating barrier extending across the container, said gel comprising liquid polybutadiene and an inorganic inert filler dispersed therein, (b) forming a partial vacuum in said container and enclosing the partially evacuated container, and (c) subjecting the container and thixotropic gel to sterilizing radiation to form a substantially sterile device without degradating the physical properties of said gel.
Claim 13
Dependent Claim
21 words
The process of claim 10 in which said filler is selected from the group consisting of silica, bentonite, alumina, and talc.
Claim 14
Dependent Claim
12 words
The process of claim 10 in which said filler is fumed silica.
Claim 15
Dependent Claim
22 words
The process of claim 10 in which said filler is present in an amount to impart a desired density to said composition.
Claim 16
Dependent Claim
20 words
The process of claim 10 in which said polybutadiene of said gel still contains carbon-to-carbon unsaturation after said sterilizing radiation.
Claim 17
Dependent Claim
22 words
The process of claim 10 in which said sterilizing radiation is at an exposure of about 2.5 megarads to about 3.5 megarads.
Claim 18
Dependent Claim
30 words
The process of claim 10 in which said gel comprises about 100 parts by weight of liquid polybutadiene and about 20 to about 60 parts by weight of said filler.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-11-25 | 1984-05-26 | 1984-11-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-11-25 | 1988-05-26 | 1988-11-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-11-25 | 1992-05-26 | 1992-11-25 | $7700.00 | Window Closed / Lapsed |