Patent US2047808A successfully refreshed from Google Patents.
Patent US4223672A successfully refreshed from Google Patents.
US4223672A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Variable volume plasma treatment chamber for an apparatus for the extracorporeal treatment of disease
Assignee: Baxter International Inc
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Filing: 1979-02-08
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Granted: 1980-09-23
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Expires: 1999-02-08
Abstract
Abstract The apparatus includes a peristaltic pump for withdrawing whole blood from a patient, a device for centrifuging the blood to separate plasma from the whole blood, a plasma treatment chamber for receiving the plasma, a vehicle positioned within the chamber and having an immuno-adsorbent agent fixed thereon to interact and bond with an immunological reactant carried by the plasma that is passed through the chamber for removing the immunological reactant from the plasma, tubing connected to recombine the substantially immunological reactant free plasma with the remainder of the whole blood and a peristaltic pump for returning the recombined whole blood to the patient. According to the present invention the plasma treatment chamber has a variable volume so that the chamber can be used for treating sequentially different quantities of plasma.
Inventors
- 👤 David S. Terman
- 👤 Herbert M. Cullis
- 👤 Mirza A. Khoja
- 👤 Michael R. Sullivan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:52
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/34; A61M1/3472; A61M1/3486; A61M1/36; A61M1/3693; A61M1/3696; A61M1/3698; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0415
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
116 words
In an apparatus for the extracorporeal treatment of diseases and of the type comprising means for withdrawing whole blood from a patient, means for separating plasma from the whole blood, means for treating the plasma including a chamber for receiving the plasma and a vehicle positioned within the chamber and having an immuno-adsorbent agent fixed thereon which will interact and bond with an immunological reactant carried by the plasma that is passed through the chamber, and means for recombining the substantially immunological reactant free plasma with the remainder of the whole blood and for returning the recombined whole blood to the patient, an improved means for treating the plasma including a variable volume plasma treatment chamber.
Claim 2
Dependent Claim
116 words
In an apparatus for the extracorporeal treatment of diseases and of the type comprising means for withdrawing whole blood from a patient, means for separating plasma from the whole blood, means for treating the plasma including a chamber for receiving the plasma and a vehicle positioned within the chamber and having an immuno-adsorbent agent fixed thereon which will interact and bond with an immunological reactant carried by the plasma that is passed through the chamber, and means for recombining the substantially immunological reactant free plasma with the remainder of the whole blood and for returning the recombined whole blood to the patient, an improved means for treating the plasma including a variable volume plasma treatment chamber.
Claim 3
Dependent Claim
44 words
The apparatus according to claim 1 wherein said variable volume plasma treatment chamber includes an elongate chamber, means for closing off one end of said chamber and a releasably fixable plunger assembly within said chamber for closing off the other end of said chamber.
Claim 4
Dependent Claim
28 words
The apparatus according to claim 2 wherein said means for closing off said one end of said chamber includes a second releasably fixable plunger assembly within said chamber.
Claim 5
Dependent Claim
29 words
The apparatus according to claim 3 wherein said chamber is defined by an elongate hollow cylinder and said plunger assemblies are received in respective opposite ends of said cylinder.
Claim 6
Dependent Claim
42 words
The apparatus according to claim 4 wherein said cylinder is made of a light transmitting material and has graduations thereon so that the exact position of said plunger assemblies and the volume therebetween can be visually observed from outside of said cylinder.
Claim 7
Dependent Claim
33 words
The apparatus according to claim 2 wherein said releasably fixable plunger assembly has a central passageway therethrough in communication with the interior of said chamber and adapted to be connected to a conduit.
Claim 8
Dependent Claim
46 words
The apparatus according to claim 6 wherein said chamber is defined by an elongate hollow cylinder and said plunger assembly includes a piston having a stem portion and a larger diameter cylindrical portion said passageway extending through said stem portion and said larger diameter cylindrical portion.
Claim 9
Dependent Claim
22 words
The apparatus according to claim 7 wherein said piston has a reduced-in-diameter portion between said stem portion and said larger diameter portion.
Claim 10
Dependent Claim
20 words
The apparatus according to claim 8 wherein said plunger assembly includes means for releasably fixing said piston within said cylinder.
Claim 11
Dependent Claim
88 words
The apparatus according to claim 9 wherein said piston fixing means includes a cup shaped member which is received about said reduced-in-diameter portion of said piston and which has a bore in the top thereof through which said stem portion extends, an elastomeric O-ring situated between said cup shaped member and said larger diameter portion and means for urging and holding said cup shaped member against said larger diameter portion of said piston with said O-ring squeezed therebetween to form a seal between said piston and said cylinder.
Claim 12
Dependent Claim
44 words
The apparatus according to claim 10 wherein said means for urging and holding said cup shaped member against said piston includes a plurality of fasteners received through said cup shaped member and threadingly received within a like plurality of threaded bores in said piston.
Claim 13
Dependent Claim
41 words
The apparatus according to claim 10 wherein said means for urging and holding said cup shaped member against said piston includes cooperating threaded portions on said stem portion and on the inner surface of said bore through said cup shaped member.
Claim 14
Dependent Claim
124 words
The apparatus according to claim 12 wherein said piston fixing means includes a washer fixed against rotation on said reduced-in-diameter portion of said piston between said O-ring and said cup shaped member and wherein said means for urging and holding said cup shaped member against said piston includes a tubular extension of said cup shaped member which has said bore extending therethrough and which has gripping means on the outer end thereof for facilitating rotation of said cup shaped member to thread said cup shaped member on said stem portion of said piston and against said washer which is positioned to engage and squeeze said O-ring between said washer and said larger diameter portion of said piston and the inner wall of said cylinder.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-23 | 1984-03-24 | 1984-09-23 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-23 | 1988-03-24 | 1988-09-23 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-23 | 1992-03-24 | 1992-09-23 | $7700.00 | Window Closed / Lapsed |