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US4222389A
Expired / Lapsed
US
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Objective determination of the rate of oxygen utilization in peripheral tissue
Assignee: Institute of Applied Biology Special Cancer Research Project
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Filing: 1977-10-18
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Granted: 1980-09-16
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Expires: 1997-10-18
Abstract
Abstract A non-invasive method of objectively determining, in vivo, the rate of oxygen utilization in peripheral tissue by spectral measuring means, which involves isolating a segment of blood in the tissue with a clamp or tourniquet, and obtaining rapid, successive spectral curves of the oxyhemoglobin in the occluded area, to and from selected wavelengths of light, and measuring the time-space relationship between a rapidly moving portion of the spectral curve and a slower moving adjacent portion of the same curve, from the moment of occlusion, to establish a rate of reduction of the oxyhemoglobin in the tissue which is directly correlated to the rate of oxygen utilization.
Inventors
- 👤 Harry E. Rubens
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:15
CPC Classifications
A; A61; A61B; A61B10/00; A61B90/00; A61B90/06
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
90 words
A non-invasive, spectrometric method of objectively determining in vivo, the rate of oxygen utilization in peripheral tissue, which comprises isolating a segment of blood in the tissue of the skin, and simultaneously and rapidly obtaining from the moment of blood isolation, the changing light coefficients of absorption for oxyhemoglobin in the isolated blood, at two adjacent wavelengths in which the coefficients of absorption of one wavelength, has a faster rate of change than the other, and determining the rate of change of one light coefficient with respect to the other.
Claim 2
Dependent Claim
90 words
A non-invasive, spectrometric method of objectively determining in vivo, the rate of oxygen utilization in peripheral tissue, which comprises isolating a segment of blood in the tissue of the skin, and simultaneously and rapidly obtaining from the moment of blood isolation, the changing light coefficients of absorption for oxyhemoglobin in the isolated blood, at two adjacent wavelengths in which the coefficients of absorption of one wavelength, has a faster rate of change than the other, and determining the rate of change of one light coefficient with respect to the other.
Claim 3
Dependent Claim
27 words
The method of claim 1, in which the selected wavelengths of oxyhemoglobin are taken from adjacent wavelengths at the 245, 280, 350, 417, 548 and 578 nm.
Claim 4
Dependent Claim
16 words
The method of claim 1, in which the adjacent wavelengths are about 565 and 578 nm.
Claim 5
Dependent Claim
43 words
The method of claim 1, in which the rate of change of one light coefficient with respect to the other is measured by the time required from the moment of blood isolation, for one coefficient of absorption to equal that of the other.
Claim 6
Dependent Claim
50 words
The method of claim 1, in which the rate of change of one light coefficient with respect to the other is measured by the time required from the moment of blood isolation, for the coefficient of absorption at 578 nm, to equal the coefficient of absorption at about 565 nm.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-09-16 | 1984-03-17 | 1984-09-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-09-16 | 1988-03-17 | 1988-09-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-09-16 | 1992-03-17 | 1992-09-16 | $7700.00 | Window Closed / Lapsed |