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US4213462A Expired / Lapsed US ⏱️ 0.0 years remaining

Optical assembly for detecting an abnormality of an organ or tissue and method

Assignee: Individual
•
Filing: 1978-08-18
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Granted: 1980-07-22
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Expires: 1998-08-18
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Abstract

Abstract The present invention relates to a method of detecting an abnormality of cell growth in an organ or tissue of a body and various optical assemblies for accomplishing the same. The present invention has discovered that diagnosis of incipient abnormal tissue growth such as cancer can be accomplished in vivo by exerting a predetermined pressure on the suspected tissue or organ and by subsequently comparing the relative effect on reflection from or light absorption of the tissue or organ. An optical probe can be utilized for scanning the suspected tissue or organ and recording an initial reflecting characteristic. Subsequently the tissue or organ is placed under a predetermined pressure to provide a second reflection characteristic. A comparison of the two signals will permit a diagnosis of the condition of the tissue or organ. As can be appreciated, a fiber optic bundle can be used for the optical probe and a data processor can automatically compute either the difference or the ratio of the two signals with a corresponding display or printing of the information. Alternative embodiments are disclosed herein.

Inventors

  • 👤 Nobuhiro Sato

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 10:36
CPC Classifications
A; A61; A61B; A61B1/00; A61B1/273; A61B1/2736; A61B5/00; A61B5/0059; A61B5/0062; A61B5/0064; A61B5/0075; A61B5/0082; A61B5/0084; A61B5/145; A61B5/1455; A61B5/68; A61B5/6801; A61B5/6843; G; G01; G01N; G01N21/00; G01N21/84; G01N21/85; G01N21/8507; A61B5/44; A61B5/441

Claims Analysis

Total Claims: 24
Claim 1
Independent Claim 166 words
An optical device for detecting an abnormality in an organ or tissue in its early stages of growth comprising: a light source assembly; contact means including a portion for contacting a surface of an organ or tissue and capable of exerting a predetermined pressure thereon; first means for transmitting light from the light source assembly to the tissue or organ that will be effected by the predetermined pressure; means for measuring the light intensity reflected from the organ or tissue; second means for transmitting reflected light from the tissue or organ that will be effected by the predetermined pressure to the means for measuring the light intensity; means for determining a first measurement of light reflected from the organ or tissue with approximately no pressure applied and for determining a second measurement at a predetermined pressure, and means for comparing the first and second measurements to detect whether an abnormality exists in the organ or tissue as a function of the difference in measured reflected light.
Claim 2
Dependent Claim 166 words
An optical device for detecting an abnormality in an organ or tissue in its early stages of growth comprising: a light source assembly; contact means including a portion for contacting a surface of an organ or tissue and capable of exerting a predetermined pressure thereon; first means for transmitting light from the light source assembly to the tissue or organ that will be effected by the predetermined pressure; means for measuring the light intensity reflected from the organ or tissue; second means for transmitting reflected light from the tissue or organ that will be effected by the predetermined pressure to the means for measuring the light intensity; means for determining a first measurement of light reflected from the organ or tissue with approximately no pressure applied and for determining a second measurement at a predetermined pressure, and means for comparing the first and second measurements to detect whether an abnormality exists in the organ or tissue as a function of the difference in measured reflected light.
Claim 3
Dependent Claim 26 words
The invention of claim 1 wherein the first and second means for transmitting light are optical fibers capable of entering a cavity of the human body.
Claim 4
Dependent Claim 33 words
The invention of claim 1 wherein the light source assembly includes a multi-wavelength light source and the means for measuring the light intensity includes a detector for measuring the intensity of different wavelengths.
Claim 5
Dependent Claim 49 words
The invention of claim 1 wherein the contact means includes a probe member capable of entering a cavity of the human body and means for exerting a predetermined pressure on the organ or tissue in correlation with the means for determining a first and second measurement of reflected light.
Claim 6
Dependent Claim 42 words
The invention of claim 4 further including a reference wavelength from the light source assembly and a circuit means for removing noise from the measurements as a function of the difference between the reference wavelength measurement and the first and second measurements.
Claim 7
Dependent Claim 232 words
An optical device for detecting an abnormality of an organ or tissue in its early stages of growth comprising: a first light source means of a predetermined light intensity; a second contact means including a transparent portion capable of contacting a surface of an organ or tissue and exerting a predetermined pressure thereon; third means for transmitting light from the first light source means to the transparent portion of the second contact means; fourth means for measuring reflected light from the organ or tissue to produce at least a pair of signals, a first signal representative of light reflected when substantially no pressure is exerted by the transparent portion and a second signal representative of light reflected when a predetermined pressure is exerted on the organ or tissue by the transparent portion including comparison means for providing a quantitative measurement of the two signals in such a format to permit subsequent comparison processing to determine the existence of an abnormality of an organ or tissue by a substantial similarity in detected reflected light energy; fifth means for transmitting the light reflected from the organ or tissue through the transparent portion to the fourth measuring means; sixth means for forcing the transparent portion against the surface of the organ or tissue at a predetermined pressure, and seventh means for detecting the predetermined pressure condition and correlating the resulting measurement by the fourth means.
Claim 8
Dependent Claim 232 words
An optical device for detecting an abnormality of an organ or tissue in its early stages of growth comprising: a first light source means of a predetermined light intensity; a second contact means including a transparent portion capable of contacting a surface of an organ or tissue and exerting a predetermined pressure thereon; third means for transmitting light from the first light source means to the transparent portion of the second contact means; fourth means for measuring reflected light from the organ or tissue to produce at least a pair of signals, a first signal representative of light reflected when substantially no pressure is exerted by the transparent portion and a second signal representative of light reflected when a predetermined pressure is exerted on the organ or tissue by the transparent portion including comparison means for providing a quantitative measurement of the two signals in such a format to permit subsequent comparison processing to determine the existence of an abnormality of an organ or tissue by a substantial similarity in detected reflected light energy; fifth means for transmitting the light reflected from the organ or tissue through the transparent portion to the fourth measuring means; sixth means for forcing the transparent portion against the surface of the organ or tissue at a predetermined pressure, and seventh means for detecting the predetermined pressure condition and correlating the resulting measurement by the fourth means.
Claim 9
Dependent Claim 23 words
The invention of claim 6 further comprising an eighth means for storing the first and second light measuring signals of the fourth means.
Claim 10
Dependent Claim 53 words
The invention of claim 7 further comprising a ninth means connected to the eighth means for deriving signals from the stored first and second light measuring signals according to a predetermined data operation function and a tenth means responsive to the signals of the ninth means for displaying the contents of the signals.
Claim 11
Dependent Claim 21 words
The invention of claim 8, wherein the first means includes a spectroscope and the fourth means includes a light measuring element.
Claim 12
Dependent Claim 53 words
The invention of claim 8, wherein the first means includes a device for emitting light across a wide band of wavelengths and the fourth means includes means for deriving a spectrum from the light transmitted by the fifth means and means for individually receiving a plurality of colors of light in the spectrum.
Claim 13
Dependent Claim 40 words
The invention of claim 6, wherein the second means includes a first member which is free from any contact with the organ or tissue and a second member having the transparent portion and being movable relatively to the first member.
Claim 14
Dependent Claim 19 words
The invention of claim 11 wherein the sixth means includes a spring connected between the first and second members.
Claim 15
Dependent Claim 44 words
The invention of claim 11, wherein the sixth means includes a fluid filled between the first and second members and means for varying the pressure of the fluid and wherein the seventh means further includes a device for detecting the pressure of the fluid.
Claim 16
Dependent Claim 25 words
The invention of claim 11, wherein the seventh means includes a device for detecting the position of the second member relative to the first member.
Claim 17
Dependent Claim 33 words
The invention of claim 14, wherein the detecting device is a switch which can be closed in accordance with a change in the position of the second member relative to the first member.
Claim 18
Dependent Claim 41 words
The invention of claim 14, wherein the detecting device includes an optical means for reading the position of the second member relative to the first member to derive an output pulse signal and a counter for counting the output pulse signal.
Claim 19
Independent Claim 136 words
A method of optically detecting an abnormality such as cancer at its incipient stage of growth in a body portion of an organ or tissue in vivo comprising the steps of; directing a first quantity of light energy at the body portion under diagnoses of such a wavelength that it is reflectable from the surface of the organ or tissue; detecting the intensity of first light energy reflection from the body portion; placing the body portion under a predetermined pressure; directing a second quantity of light energy at the body portion under diagnoses; detecting the intensity of second light energy reflection from the body portion under diagnoses, and comparing the first and second detected light energy reflection whereby a substantial similarity in detected intensity of light energy reflection indicates an abnormal condition in the body portion.
Claim 20
Independent Claim 136 words
A method of optically detecting an abnormality such as cancer at its incipient stage of growth in a body portion of an organ or tissue in vivo comprising the steps of; directing a first quantity of light energy at the body portion under diagnoses of such a wavelength that it is reflectable from the surface of the organ or tissue; detecting the intensity of first light energy reflection from the body portion; placing the body portion under a predetermined pressure; directing a second quantity of light energy at the body portion under diagnoses; detecting the intensity of second light energy reflection from the body portion under diagnoses, and comparing the first and second detected light energy reflection whereby a substantial similarity in detected intensity of light energy reflection indicates an abnormal condition in the body portion.
Claim 21
Dependent Claim 20 words
The invention of claim 17 wherein a spring force is used to apply the predetermined pressure to the body portion.
Claim 22
Dependent Claim 21 words
The invention of claim 17 wherein a liquid pressure force is used to apply the predetermined pressure to the body portion.
Claim 23
Dependent Claim 24 words
The invention of claim 17 wherein the directing steps include directing a multi-wavelength of light energy in the visible spectrum at the body portion.
Claim 24
Dependent Claim 32 words
The invention of claim 20 further including directing at least a third wavelength of energy at the body portion to provide a reference for removing any error noise for the detected intensity.

References Cited (Backward Citations)

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US2437916A Cited
US2790438A Cited
US3412729A Cited
US3461856A Cited
DE2053301A1 Cited
US3825342A Cited
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USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1983-07-22 1984-01-21 1984-07-22 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1987-07-22 1988-01-21 1988-07-22 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1991-07-22 1992-01-21 1992-07-22 $7700.00 Window Closed / Lapsed

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