Patent US4184020A successfully refreshed from Google Patents.
US4184020A
Expired / Lapsed
US
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Preparation of hydrophilic material for gel chromatography
Assignee: Czech Academy of Sciences
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Filing: 1977-08-19
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Granted: 1980-01-15
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Expires: 1997-08-19
Abstract
Abstract This invention relates to a method for preparing globular, hydrophilic copolymers which have reticulated internal structures and are suitable for gas and gel chromatography. The method comprises polymerization by suspension polymerization methods of hydrophilic and hydrophilic monomers in aqueous medium in the presence of a component which prevents transfer of the hydrophilic monomer into the aqueous medium and the solubility of the aqueous medium in the monomeric phase.
Inventors
- 👤 Drahoslav Lim
- 👤 Jiri Coupek
- 👤 Miroslava Krivakova
- 👤 Svatopluk Pokorny
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:37
CPC Classifications
B; B01; B01J; B01J20/00; B01J20/281; B01J20/291; B01J20/22; C; C08; C08F; C08F2/00; C08F2/12; C08F2/16; C08F2/18; B01J2220/00; B01J2220/50; B01J2220/54; C08F220/00; C08F220/02; C08F220/10; C08F220/20
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
228 words
A method for preparing insoluble globular hydrophilic copolymers of macroreticulated internal structure comprising suspension polymerizing a mixture of (a) a hydroxylalkyl methacrylate, and (b) a hydrophobic monomer selected from the group consisting of ethylene dimethacrylate and ethylene diacrylate, the hydroxyalkyl methacylate being present in amount of at least 70% by weight of said mixture, in an aqueous medium in the presence of a polymerization initiator and in the presence of (1) a first inert organic compound selected from the group consisting of cyclohexanol and cyclohexylamine, and (2) a second inert organic compound selected from the group consisting of dodecyl alcohol, n-octyl alcohol, decyl alcohol, dibutyl ether, hexadecyl alcohol, n-hexadecyl acetate and dodecyl amine, said first inert compound being soluble in the monomer mixture and insoluble in water, the value of the partition coefficient of the hydrophobic monomer between water and said first inert compound being limited to substantially zero, thus preventing extraction of the hydrophilic monomer into the aqueous phase, the second inert compound being insoluble in water, soluble in the monomer and being a precipitant for the copolymer, the inert organic compounds (1) and (2) being present in weight amount of from about 17.32% to about 18.36% of the weight of water present in said aqueous medium, the weight ratio between the compound (1) and the compound (2) being in the range of about 2.32:1 to 2.82:1.
Claim 2
Independent Claim
228 words
A method for preparing insoluble globular hydrophilic copolymers of macroreticulated internal structure comprising suspension polymerizing a mixture of (a) a hydroxylalkyl methacrylate, and (b) a hydrophobic monomer selected from the group consisting of ethylene dimethacrylate and ethylene diacrylate, the hydroxyalkyl methacylate being present in amount of at least 70% by weight of said mixture, in an aqueous medium in the presence of a polymerization initiator and in the presence of (1) a first inert organic compound selected from the group consisting of cyclohexanol and cyclohexylamine, and (2) a second inert organic compound selected from the group consisting of dodecyl alcohol, n-octyl alcohol, decyl alcohol, dibutyl ether, hexadecyl alcohol, n-hexadecyl acetate and dodecyl amine, said first inert compound being soluble in the monomer mixture and insoluble in water, the value of the partition coefficient of the hydrophobic monomer between water and said first inert compound being limited to substantially zero, thus preventing extraction of the hydrophilic monomer into the aqueous phase, the second inert compound being insoluble in water, soluble in the monomer and being a precipitant for the copolymer, the inert organic compounds (1) and (2) being present in weight amount of from about 17.32% to about 18.36% of the weight of water present in said aqueous medium, the weight ratio between the compound (1) and the compound (2) being in the range of about 2.32:1 to 2.82:1.
Claim 3
Dependent Claim
13 words
A method according to claim 1 wherein the hydrophobic monomer is ethylene dimethacrylate.
Claim 4
Dependent Claim
13 words
A method according to claim 1 wherein the hydrophobic monomer is ethylene diacrylate.
Claim 5
Dependent Claim
14 words
A method according to claim 1 wherein said first inert organic compound is cyclohexanol.
Claim 6
Dependent Claim
14 words
A method according to claim 1 wherein said first inert organic compound is cyclohexylamine.
Claim 7
Dependent Claim
16 words
A method according to claim 1 wherein said second inert organic compound (2) is dodecyl alcohol.
Claim 8
Dependent Claim
16 words
A method according to claim 1 wherein said second inert organic compound (2) is n-octyl alcohol.
Claim 9
Dependent Claim
13 words
A method according to claim 1 wherein there is present a suspension stabilizer.
Claim 10
Dependent Claim
12 words
A method according to claim 8 wherein said suspension stabilizer is polyvinylpyrrolidone.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1983-01-14 | 1983-07-16 | 1984-01-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1987-01-14 | 1987-07-16 | 1988-01-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1991-01-14 | 1991-07-16 | 1992-01-15 | $7700.00 | Window Closed / Lapsed |