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US4181718A
Expired / Lapsed
US
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Polyanion-stabilized aluminum hydrogels
Assignee: Individual
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Filing: 1978-02-13
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Granted: 1980-01-01
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Expires: 1998-02-13
Abstract
Abstract Aluminum hydrogels which are stabilized at pH below 7 with a polymer containingcarboxyl groups, e.g., carboxy methyl cellulose or gum arabic. The gels are useful as phosphate binding agents in the treatment of hyperphosphatemia. Such polymers are incorporated during the formation of the aluminum hydrogel, permitting a high yield to be obtained, and preventing colloidal sol formation during exchange with monovalent anions.
Inventors
- 👤 Norbert S. Mason
- 👤 Robert E. Sparks
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:21
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/30; A61K47/36; A21; A21D; A21D2/00; A21D2/02; A21D2/08; A21D2/14; A61K31/00; A61K31/70; A61K31/715; A61K31/74; A61K31/765; A61K33/00; A61K33/06; A61K47/38
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
49 words
A non-astringent phosphate binding agent having a high phosphate binding capacity which capacity is maintained upon dehydration comprising a stabilized hydrogel of an aluminum salt and a carboxy-containing polymeric anion having a molecular weight of from 1,000 to 700,000, with the hydrogel formed at a pH below about 7.
Claim 2
Dependent Claim
49 words
A non-astringent phosphate binding agent having a high phosphate binding capacity which capacity is maintained upon dehydration comprising a stabilized hydrogel of an aluminum salt and a carboxy-containing polymeric anion having a molecular weight of from 1,000 to 700,000, with the hydrogel formed at a pH below about 7.
Claim 3
Dependent Claim
30 words
The phosphate binding agent of claim 1 wherein the aluminum salt is aluminum acetate and the polymeric anion is selected from the group consisting of gum arabic and carboxymethyl cellulose.
Claim 4
Dependent Claim
50 words
A method of preparing the phosphate binding agent of claim 1, which comprises neutralizing an aluminum salt at a pH of from 3.5 to 7.0 to form an aluminum hydrogel, exchanging the anion of the aluminum hydrogel with a pharmaceutically acceptable anion in the presence of the stabilizing polymeric anion.
Claim 5
Dependent Claim
16 words
The method of claim 3, wherein the neutralization pH range is from pH 4.0 to 7.0.
Claim 6
Dependent Claim
57 words
A method of preparing the phosphate binding agent of claim 1, which comprises neutralizing a mixture of an aluminum salt and a polymeric anion at a pH of from 3.5 to 7.0, to form an aluminum hydrogel stabilized by the polymeric anion, and subsequently exchanging the anion of the stabilized alumiunum hydrogel with a pharmaceutically acceptable anion.
Claim 7
Dependent Claim
16 words
The method of claim 5, wherein the neutralization pH range is from pH 4.0 to 7.0.
Claim 8
Dependent Claim
50 words
A method of preparing the phosphate binding agent of claim 1, which comprises neutralizing an aluminum salt at a pH of 3.5 to 7.0, to form an aluminum hydrogel in the presence of the polymeric anion, and subsequently exchanging the anion of the aluminum hydrogel with a pharmaceutically acceptable anion.
Claim 9
Dependent Claim
16 words
The method of claim 7, wherein the neutralization pH range is from pH 4.0 to 7.0.
Claim 10
Dependent Claim
46 words
A method of preparing the phosphate binding agent of claim 1, which comprises partially neutralizing an aluminum salt at a pH of from 3.5 to 7.0, to form an aluminum hydrogel, and subsequently completely neutralizing the aluminum hydrogel in the presence of the stabilizing polymeric anion.
Claim 11
Dependent Claim
16 words
The method of claim 9, wherein the neutralization pH range is from pH 4.0 to 7.0.
Claim 12
Dependent Claim
41 words
A method of preparing the phosphate binding agent of claim 1, which comprises neutralizing a mixture of an aluminum salt and the polymeric anion at a pH of from 3.5 to 7.0, to form an aluminum hydrogel, with a polymeric anion.
Claim 13
Dependent Claim
16 words
The method of claim 11, wherein the neutralization pH range is from pH 4.0 to 7.0.
Claim 14
Dependent Claim
28 words
A method of treating hyperphosphatemia, which comprises administering to a mammal in need of such treatment a hyperphosphatemic effective amount of a phosphate binding agent of claim 1.
Claim 15
Dependent Claim
22 words
The method of treating hyperphosphatemia according to claim 13, wherein the phosphate binding agent is administered in the form of a tablet.
Claim 16
Dependent Claim
23 words
The method of treating hyperphosphatemia according to claim 13, wherein the phosphate binding agent is administered in the form of a bread stick.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-12-31 | 1983-07-02 | 1984-01-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-12-31 | 1987-07-02 | 1988-01-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-12-31 | 1991-07-02 | 1992-01-01 | $7700.00 | Window Closed / Lapsed |