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US4173654A
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Novel fluorohydrocarbons
Assignee: California Institute of Technology
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Filing: 1977-01-03
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Granted: 1979-11-06
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Expires: 1997-01-03
Abstract
Abstract Novel fluorohydrocarbons include a fluoroalkyl unit terminating in a tertiary carbon atom which is directly linked to an aliphatic moiety of the compound. The compounds contain at least 9 carbon atoms and usually no more than 13 carbon atoms. The compounds are synthesized by addition of a fluoride atom to the tertiary carbon atom of a fluorocarbon material to form a carbanion followed by alkylation of the carbanion. The fluorohydrocarbons will find use as blood substitutes or as electronic fluids.
Inventors
- 👤 Kirby V. Scherer
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:45
CPC Classifications
C; C07; C07C; C07C17/00; C07C17/26; C07C17/263; C07C17/269; C07C17/272; C07C17/278; C07C17/35; C07C17/358; C07C19/00; C07C19/08; C07C21/00; C07C21/02; C07C21/18
Claims Analysis
Total Claims: 12
Claim 1
Independent Claim
72 words
A fluorochemical compound containing 9 to 15 carbon atoms selected from compounds of the formulae: ##STR12## where R f =C n F 2n +1 R f '=C n' F 2n' +1 R f "=C n" F 2n" +1 and n, n' and n" are integers from 1 to 11 and Z is a hydrocarbon moiety containing at least 2 hydrogen atoms and has a methylene group connected to the tertiary carbon atom.
Claim 2
Dependent Claim
72 words
A fluorochemical compound containing 9 to 15 carbon atoms selected from compounds of the formulae: ##STR12## where R f =C n F 2n +1 R f '=C n' F 2n' +1 R f "=C n" F 2n" +1 and n, n' and n" are integers from 1 to 11 and Z is a hydrocarbon moiety containing at least 2 hydrogen atoms and has a methylene group connected to the tertiary carbon atom.
Claim 3
Dependent Claim
53 words
A compound according to claim 1 in which the compound contains from 9 to 13 carbon atoms and Z is a metabolically reactive hydrocarbon and the compound has a vapor pressure <50 mm Hg at 37° C. to 39° C. and an oxygen solubility of at least 30 volume percent at 37.5° C.
Claim 4
Dependent Claim
28 words
A compound according to claim 2 in which Z is selected from compounds of the formula: --CH.sub.2 --(CH.sub.2).sub.m --H where m is an integer from 0 to 8.
Claim 5
Dependent Claim
14 words
A compound according to claim 3 in which Z contains straight chain alkyl groups.
Claim 6
Dependent Claim
18 words
A compound according to claim 1 in which at least two of n, n' and n" are 1.
Claim 7
Dependent Claim
7 words
The compound according to claim 1: ##STR13##
Claim 8
Dependent Claim
7 words
The compound according to claim 1: ##STR14##
Claim 9
Dependent Claim
12 words
The compound according to claim 1: CF.sub.3 --CF.sub.2 --CF.sub.2 --C(CF.sub.3).sub.2 --CH.sub.2 --CH═CH.sub.2
Claim 10
Dependent Claim
45 words
A method of forming compounds of claim 1 comprising the steps of reacting a fluoroolefin of the formula: ##STR15## where n is an integer from 0 to 10 with a fluoride ion to form a tertiary fluorocarbanion; and alkylating the carbanion with an electrophilic reagent.
Claim 11
Dependent Claim
41 words
An artificial blood substitute comprising a fluorohydrocarbon aqueous emulsion containing: an effective amount of at least 15% by volume of a fluorochemical compound as defined in claim 2; 1 to 10% by weight of surfactant; and remainder physiologically acceptable aqueous carrier.
Claim 12
Dependent Claim
16 words
An emulsion according to claim 10 further including effective amounts of osmotic, pH and oncotic agents.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-11-05 | 1983-05-07 | 1983-11-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-11-05 | 1987-05-07 | 1987-11-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-11-05 | 1991-05-07 | 1991-11-06 | $7700.00 | Window Closed / Lapsed |