US4151108A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Reference liquid for blood gas equipment
Assignee: Radiometer AS
•
Filing: 1977-06-15
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Granted: 1979-04-24
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Expires: 1997-06-15
Abstract
Abstract A reference liquid for the calibration and/or quality control of blood gas analyzers. The reference liquid comprises an aqueous phase and either polymer-coated microcapsules containing at least one organic substance functioning as oxygen carrier, or porous particles of a solid substance functioning as oxygen carrier. An example of the polymer-coated microcapsules is nylon-coated microcapsules containing a mixture of perfluorotributyl amine and isooctane. An example of the porous particles of a solid substance is particles of porous silicone rubber.
Inventors
- 👤 Soren K. Sorensen
- 👤 Carl C. Holbek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:16
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1495; B; B01; B01J; B01J13/00; B01J13/02; B01J13/025; A61B2560/00; A61B2560/02; A61B2560/0223; A61B2560/0228; A61B2560/0233; G01N2496/00; G01N2496/10; G01N2496/15; G01N2496/70; Y; Y10; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2985; Y10T428/2987; Y10T436/00; Y10T436/10; Y10T436/102499; Y10T436/108331
Claims Analysis
Total Claims: 13
Claim 1
Independent Claim
86 words
A synthetic reference liquid for quality control and/or calibration of blood gas measuring equipment, said reference liquid showing, at a fixed temperature, a known pH, PCO 2 and PO 2 value, said reference liquid comprising an aqueous phase containing at least one pH buffer system and particles suspended in said aqueous phase, the particles being either (1) polymeric oxygen-permeable microcapsules containing at least one organic liquid which shows a considerably greater ability to reversibly contain oxygen than does water, or (2) particles of porous silicone rubber.
Claim 2
Dependent Claim
86 words
A synthetic reference liquid for quality control and/or calibration of blood gas measuring equipment, said reference liquid showing, at a fixed temperature, a known pH, PCO 2 and PO 2 value, said reference liquid comprising an aqueous phase containing at least one pH buffer system and particles suspended in said aqueous phase, the particles being either (1) polymeric oxygen-permeable microcapsules containing at least one organic liquid which shows a considerably greater ability to reversibly contain oxygen than does water, or (2) particles of porous silicone rubber.
Claim 3
Dependent Claim
27 words
A reference liquid as claimed in claim 1 in which the aqueous phase contains a hydrogen carbonate ion-carbon dioxide-pH buffer system and a phosphate pH buffer system.
Claim 4
Dependent Claim
23 words
A reference liquid as claimed in claim 1 in which the microcapsules contain a hydrocarbon, a fluorocarbon compound, an ester and/or silicon oil.
Claim 5
Dependent Claim
14 words
A reference liquid as claimed in claim 3 in which the microcapsules contain isooctane.
Claim 6
Dependent Claim
15 words
A reference liquid as claimed in claim 3 in which the microcapsules contain perfluorotributyl amine.
Claim 7
Dependent Claim
20 words
A reference liquid as claimed in claim 3 in which the microcapsules contain a mixture of isooctane and perfluorotributyl amine.
Claim 8
Dependent Claim
24 words
A reference liquid as claimed in claim 6 in which the ratio, by volume, between isooctane and perfluorotributyl amine in the microcapsules is 7-8:3-2.
Claim 9
Dependent Claim
16 words
A reference liquid as claimed in claim 7 in which the volume ratio is about 3:1.
Claim 10
Dependent Claim
17 words
A reference liquid according to claim 1 in which the polymeric wall of the microcapsules is nylon.
Claim 11
Dependent Claim
23 words
A reference liquid as claimed in claim 1, and further comprising a coloring component showing maximum or significant absorption at about 500 nm.
Claim 12
Dependent Claim
19 words
A reference liquid according to claim 1, which is enclosed in a gas-tight container substantially free of gas phase.
Claim 13
Dependent Claim
19 words
A reference liquid as claimed in claim 1 in which the suspended microcapsules constitute 40-70% of the total volume.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-04-23 | 1982-10-23 | 1983-04-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-04-23 | 1986-10-23 | 1987-04-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-04-23 | 1990-10-23 | 1991-04-24 | $7700.00 | Window Closed / Lapsed |