Patent US2877324A successfully refreshed from Google Patents.
Patent US4141087A successfully refreshed from Google Patents.
US4141087A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Isomorphic copolyoxalates and sutures thereof
Assignee: Ethicon Inc
•
Filing: 1977-01-19
•
Granted: 1979-02-27
•
Expires: 1997-01-19
Abstract
Abstract Synthetic absorbable sutures are prepared from copolyoxalate polymers having isomorphic sequences. The polymers are derived from mixtures of cyclic and linear diols, each having the same carbon chain length of 6 or 8 atoms. The cyclic diol may be aliphatic or aromatic. The diols are polymerized with dialkyl oxalate, preferably in the presence of an inorganic or organometallic catalyst, to obtain a highly crystalline isomorphic copolyoxalate polymer which is melt extruded and drawn to form oriented filaments. The filaments are characterized by good initial tensile and knot strength and a high order of softness and flexibility. When implanted in living animal tissue, the fibers have good strength retention over a period of at least 21 days and eventually absorb with a minimal degree of adverse tissue reaction.
Inventors
- 👤 Shalaby W. Shalaby
- 👤 Dennis D. Jamiolkowski
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-22 21:55
CPC Classifications
A; A61; A61L; A61L17/00; A61L17/06; A61L17/10; A61L17/105; A61B; A61B17/00; A61B17/04; A61B17/06; A61B17/06114; A61B17/06133; A61B17/06166; A61L27/00; A61L27/14; A61L27/18; A61B2017/00004
Claims Analysis
Total Claims: 25
Claim 1
Independent Claim
96 words
A synthetic absorbable suture of oriented fiber comprising an isomorphic polyoxalate polymer consisting essentially of units of cyclic and linear oxalates and having the general formula ##STR2## wherein each R is --(CH.sub.2).sub.n -- A -- (CH.sub.2).sub.n -- I or '(CH.sub.2).sub.4+2n -- II and from about 5 to 95 mol percent of the R units are I; A is trans 1,4-cyclohexylene or p-phenylene, n is 1 or 2 and is the same for I and II, and x is the degree of polymerization resulting in a fiber forming polymer having a molecular weight greater than about 10,000.
Claim 2
Dependent Claim
96 words
A synthetic absorbable suture of oriented fiber comprising an isomorphic polyoxalate polymer consisting essentially of units of cyclic and linear oxalates and having the general formula ##STR2## wherein each R is --(CH.sub.2).sub.n -- A -- (CH.sub.2).sub.n -- I or '(CH.sub.2).sub.4+2n -- II and from about 5 to 95 mol percent of the R units are I; A is trans 1,4-cyclohexylene or p-phenylene, n is 1 or 2 and is the same for I and II, and x is the degree of polymerization resulting in a fiber forming polymer having a molecular weight greater than about 10,000.
Claim 3
Dependent Claim
11 words
A suture of claim 1 wherein said fiber is a monofilament.
Claim 4
Dependent Claim
11 words
A suture of claim 1 wherein said fiber is a multifilament.
Claim 5
Dependent Claim
12 words
A suture of claim 3 wherein said multifilament fiber is a braid.
Claim 6
Dependent Claim
14 words
A suture of claim 1 wherein n is 1 and A is trans 1,4-cyclohexylene.
Claim 7
Dependent Claim
14 words
A suture of claim 1 wherein n is 2 and A is trans 1,4-cyclohexylene.
Claim 8
Dependent Claim
21 words
A suture of claim 5 wherein from about 40 to 75 mol percent of the R units are of formula I.
Claim 9
Dependent Claim
13 words
A suture of claim 1 wherein n is 1 and A is p-phenylene.
Claim 10
Dependent Claim
13 words
A suture of claim 1 wherein n is 2 and A is p-phenylene.
Claim 11
Dependent Claim
16 words
A suture of claim 1 having a surgical needle attached to at least one end thereof.
Claim 12
Dependent Claim
21 words
A suture of claim 10 packaged in a sterile and dry environment within a hermetically sealed and substantially moisture impervious container.
Claim 13
Independent Claim
114 words
The method of closing a wound in living tissue which comprises approximating the wound tissue with an absorbable suture comprising of sterile, oriented fiber comprising an isomorphic copolyoxalate polymer consisting essentially of units of cyclic and linear oxalates and having the general formula ##STR3## wherein each R is -- (CH.sub.2).sub.n -- A -- (CH.sub.2).sub.n -- I or --(CH.sub.2).sub.4+2n -- II with from about 5 to 95 mol percent of the R units being I; A is trans 1,4-cyclohexylene or p-phenylene, n is 1 or 2 and is the same for I and II, and x is the degree of polymerization resulting in a fiber forming polymer having a molecular weight greater than about 10,000.
Claim 14
Independent Claim
114 words
The method of closing a wound in living tissue which comprises approximating the wound tissue with an absorbable suture comprising of sterile, oriented fiber comprising an isomorphic copolyoxalate polymer consisting essentially of units of cyclic and linear oxalates and having the general formula ##STR3## wherein each R is -- (CH.sub.2).sub.n -- A -- (CH.sub.2).sub.n -- I or --(CH.sub.2).sub.4+2n -- II with from about 5 to 95 mol percent of the R units being I; A is trans 1,4-cyclohexylene or p-phenylene, n is 1 or 2 and is the same for I and II, and x is the degree of polymerization resulting in a fiber forming polymer having a molecular weight greater than about 10,000.
Claim 15
Dependent Claim
11 words
The method of claim 12 wherein said fiber is a monofilament.
Claim 16
Dependent Claim
11 words
The method of claim 12 wherein said fiber is a multifilament.
Claim 17
Dependent Claim
12 words
The method of claim 14 wherein said multifilament fiber is a braid.
Claim 18
Dependent Claim
14 words
The method of claim 12 wherein n is 1 and A is trans 1,4-cyclohexylene.
Claim 19
Dependent Claim
14 words
The method of claim 12 wherein n is 2 and A is trans 1,4-cyclohexylene.
Claim 20
Dependent Claim
21 words
The method of claim 16 wherein units of formula I comprise from 40 to 75 mol percent of the R groups.
Claim 21
Dependent Claim
9 words
The method of claim 12 wherein A is p-phenylene.
Claim 22
Dependent Claim
105 words
A surgical prosthesis of a fabric manufactured at least in part from synthetic absorbable fibers comprising an isomorphic polyoxalate polymer consisting essentially of units of cyclic and linear oxalates and having the general formula: ##STR4## wherein each R is -- (CH.sub.2).sub.n -- A -- (CH.sub.2).sub.n -- I or --(CH.sub.2).sub.4+2n -- II with from about 5 to 95 mol percent of the R units being I; A is trans 1,4-cyclohexylene or p-phenylene, n is 1 or 2 and is the same for I and II, and x is the degree of polymerization resulting in a fiber forming polymer having a molecular weight greater than about 10,000.
Claim 23
Dependent Claim
105 words
A surgical prosthesis of a fabric manufactured at least in part from synthetic absorbable fibers comprising an isomorphic polyoxalate polymer consisting essentially of units of cyclic and linear oxalates and having the general formula: ##STR4## wherein each R is -- (CH.sub.2).sub.n -- A -- (CH.sub.2).sub.n -- I or --(CH.sub.2).sub.4+2n -- II with from about 5 to 95 mol percent of the R units being I; A is trans 1,4-cyclohexylene or p-phenylene, n is 1 or 2 and is the same for I and II, and x is the degree of polymerization resulting in a fiber forming polymer having a molecular weight greater than about 10,000.
Claim 24
Dependent Claim
105 words
A surgical prosthesis of a solid surgical aid cast or machined from an absorbable polymer comprising an isomorphic polyoxalate polymer consisting essentially of units of cyclic and linear oxalates and having the general formula ##STR5## wherein each R is -- (CH.sub.2).sub.n -- A -- (CH.sub.2).sub.n -- I or --(CH.sub.2).sub.4+2n -- II with from about 5 to 95 mol percent of the R units being I; A is trans 1,4-cyclohexylene or p-phenylene, n is 1 or 2, and is the same for I and II, and x is the degree of polymerization resulting in a fiber forming polymer having a molecular weight greater than about 10,000.
Claim 25
Dependent Claim
105 words
A surgical prosthesis of a solid surgical aid cast or machined from an absorbable polymer comprising an isomorphic polyoxalate polymer consisting essentially of units of cyclic and linear oxalates and having the general formula ##STR5## wherein each R is -- (CH.sub.2).sub.n -- A -- (CH.sub.2).sub.n -- I or --(CH.sub.2).sub.4+2n -- II with from about 5 to 95 mol percent of the R units being I; A is trans 1,4-cyclohexylene or p-phenylene, n is 1 or 2, and is the same for I and II, and x is the degree of polymerization resulting in a fiber forming polymer having a molecular weight greater than about 10,000.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-02-26 | 1982-08-28 | 1983-02-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-02-26 | 1986-08-28 | 1987-02-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-02-26 | 1990-08-28 | 1991-02-27 | $7700.00 | Window Closed / Lapsed |