US4137223A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Method of preserving blood plasma II
Assignee: Edward Shanbrom Inc
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Filing: 1977-09-19
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Granted: 1979-01-30
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Expires: 1997-09-19
Abstract
Abstract Polyethylene glycol or poly(oxyethylene)poly(oxypropylene) glycol block copolymers or both and heparin in a suitable buffer, such as citrated saline, are added to blood plasma to preserve and protect blood coagulation factors and other proteins.
Inventors
- 👤 Edward Shanbrom
- 👤 Robert C. Bishop
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:29
CPC Classifications
A; A61; A61K; A61K35/00; A61K35/12; A61K35/14; A61K35/16; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 2
Claim 1
Independent Claim
119 words
The method of preserving blood plasma coagulation factors and other proteins during freezing and thawing of plasma for improving the recovery of coagulation proteins thereafter comprising the steps of: (a) adding to whole, fresh blood plasma a preservative solution consisting essentially of heparin and alpha-hydroxy-omega-hydroxy-poly(oxyethylene)poly(oxypropylene)poly(oxyethylene) block copolymer or mixtures of the same with polyethylene glycol to a concentration of from about 0.1 to about 25 grams of said polyol and from about 10 to about 2000 units of heparin per liter of plasma; (b) thereafter freezing the blood plasma containing said preservative; and (c) thereafter thawing the frozen blood plasma containing the preservative solution to recover therefrom plasma cryoprecipitate from which plasma proteins can be recovered in improved yield.
Claim 2
Independent Claim
119 words
The method of preserving blood plasma coagulation factors and other proteins during freezing and thawing of plasma for improving the recovery of coagulation proteins thereafter comprising the steps of: (a) adding to whole, fresh blood plasma a preservative solution consisting essentially of heparin and alpha-hydroxy-omega-hydroxy-poly(oxyethylene)poly(oxypropylene)poly(oxyethylene) block copolymer or mixtures of the same with polyethylene glycol to a concentration of from about 0.1 to about 25 grams of said polyol and from about 10 to about 2000 units of heparin per liter of plasma; (b) thereafter freezing the blood plasma containing said preservative; and (c) thereafter thawing the frozen blood plasma containing the preservative solution to recover therefrom plasma cryoprecipitate from which plasma proteins can be recovered in improved yield.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-29 | 1982-07-31 | 1983-01-30 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-29 | 1986-07-31 | 1987-01-30 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-29 | 1990-07-31 | 1991-01-30 | $7700.00 | Window Closed / Lapsed |