Patent US4132596A successfully refreshed from Google Patents.
US4132596A
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Support-aminoacylase complexes
Assignee: Rhone Poulenc Industries SA
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Filing: 1977-05-20
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Granted: 1979-01-02
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Expires: 1997-05-20
Abstract
Abstract Aminoacylase is absorbed on a porous inorganic support that has been coated with a film of cross-linked polymer containing tertiary amine or quaternary ammonium salt groups to provide support-aminoacylase complexes for use in the separation of racemic acetylamino-acids.
Inventors
- 👤 Francois Meiller
- 👤 Bernard Mirabel
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 18:37
CPC Classifications
C; C12; C12P; C12P13/00; C12P13/04; C12N; C12N11/00; C12N11/14; C12P41/00; C12P41/006; C12P41/007
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
161 words
Stable support-aminoacylase complexes having an enzymatic activity, consisting of aminoacylase adsorbed on a support in the form of an inorganic porous substance selected from the group consisting of a metal oxide and silica having a grain size between 4 μm and 5 mm, a specific surface of the order of 5 to 150 m 2 /g, a pore diameter of 500 to 2500 A, a pore volume of 0.4 to 2 ml/g, and coated in an amount of less than 10 mg/m 2 without blocking the pores of the support, with a film of cross-linked polymer containing or bearing groups selected from the group consisting of tertiary amine and quaternary ammonium salts in which the functional groups are from the group consisting essentially of ##STR4## or --CH 2 --N.sup.(±) (R) 3 X.sup.(-), in which R, which may be identical or different, represents an alkyl or hydroxyalkyl group having 1 to 4 carbon atoms and X is an inorganic or organic anion.
Claim 2
Dependent Claim
161 words
Stable support-aminoacylase complexes having an enzymatic activity, consisting of aminoacylase adsorbed on a support in the form of an inorganic porous substance selected from the group consisting of a metal oxide and silica having a grain size between 4 μm and 5 mm, a specific surface of the order of 5 to 150 m 2 /g, a pore diameter of 500 to 2500 A, a pore volume of 0.4 to 2 ml/g, and coated in an amount of less than 10 mg/m 2 without blocking the pores of the support, with a film of cross-linked polymer containing or bearing groups selected from the group consisting of tertiary amine and quaternary ammonium salts in which the functional groups are from the group consisting essentially of ##STR4## or --CH 2 --N.sup.(±) (R) 3 X.sup.(-), in which R, which may be identical or different, represents an alkyl or hydroxyalkyl group having 1 to 4 carbon atoms and X is an inorganic or organic anion.
Claim 3
Dependent Claim
22 words
Complexes as claimed in claim 1, in which the metal oxide is selected from the group consisting of titanium oxide and alumina.
Claim 4
Dependent Claim
15 words
Complexes as claimed in claim 1, in which the fixed aminoacylase is of animal origin.
Claim 5
Dependent Claim
15 words
Complexes as claimed in claim 1, in which the fixed aminoacylase is produced by microorganisms.
Claim 6
Dependent Claim
22 words
Complexes as claimed in claim 1 in which X is selected from the group consisting of chloride, sulphate, nitrate, phosphate and citrate.
Claim 7
Dependent Claim
28 words
Complexes as claimed in claim 1 in which the coating is a cross-linked polymer present in an amount within the range of 1 to 6 mg/m 2 .
Claim 8
Dependent Claim
20 words
Complexes as claimed in claim 1 in which the coated support has an exchange capacity of less than 2 meq/g.
Claim 9
Dependent Claim
21 words
Complexes as claimed in claim 1 in which the coated support has an exchange capacity within the range of 0.3-1.2 meq/g.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1982-01-01 | 1982-07-03 | 1983-01-02 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1986-01-01 | 1986-07-03 | 1987-01-02 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1990-01-01 | 1990-07-03 | 1991-01-02 | $7700.00 | Window Closed / Lapsed |