Patent US4116336A successfully refreshed from Google Patents.
US4116336A
Expired / Lapsed
US
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Package containing a reference liquid for blood gas equipment
Assignee: Radiometer AS
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Filing: 1977-03-01
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Granted: 1978-09-26
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Expires: 1997-03-01
Abstract
Abstract A package containing a reference liquid for the calibration and/or quality control of blood gas analyzers. The reference liquid is enclosed in a flexible, gas-tight container without any gas bubbles in the container, and to avoid any danger of formation of gas bubbles, the total gas pressure in the liquid is kept below 600 mm Hg at 37° C. The container is preferably a laminate bag of aluminum foil with interior layer of heat sealable plastic of low gas permeability, preferably a polyacrylonitrile copolymer.
Inventors
- 👤 Soren Kaj Sorensen
- 👤 Carl Christian Holbek
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:55
CPC Classifications
G; G01; G01N; G01N33/00; G01N33/48; G01N33/50; G01N33/96; A; A61; A61B; A61B5/00; A61B5/145; A61B5/1495; B; B01; B01J; B01J13/00; B01J13/02; B01J13/025; B65; B65D; B65D75/00; B65D75/04; B65D75/20; B65D75/22; A61B2560/00; A61B2560/02; A61B2560/0223; A61B2560/0228; A61B2560/0233; G01N2496/00; G01N2496/10; G01N2496/15; G01N2496/70; Y; Y10; Y10T; Y10T436/00; Y10T436/10; Y10T436/102499
Claims Analysis
Total Claims: 15
Claim 1
Independent Claim
75 words
A package containing a synthetic reference liquid for quality control and/or calibration of blood gas measuring equipment, said liquid being enclosed in a flexible, gas-tight container without the presence of any gas phase in the container and showing (at a fixed temperature) a known pH, a known partial pressure of carbon dioxide and a known partial pressure of oxygen, the total gas pressure in said liquid being less than 600 mm Hg at 37° C.
Claim 2
Dependent Claim
75 words
A package containing a synthetic reference liquid for quality control and/or calibration of blood gas measuring equipment, said liquid being enclosed in a flexible, gas-tight container without the presence of any gas phase in the container and showing (at a fixed temperature) a known pH, a known partial pressure of carbon dioxide and a known partial pressure of oxygen, the total gas pressure in said liquid being less than 600 mm Hg at 37° C.
Claim 3
Dependent Claim
25 words
A package as claimed in claim 1 wherein the total pressure of gases in the liquid is less than 550 mm Hg at 37° C.
Claim 4
Dependent Claim
28 words
A package as claimed in claim 1 wherein the reference liquid is an aqueous solution containing a hydrogen carbonate ion--carbon dioxide buffer system and a phosphate buffer system.
Claim 5
Dependent Claim
17 words
A package as claimed in claim 1 wherein the flexible, gas-tight container is a metal-plastic laminate bag.
Claim 6
Dependent Claim
44 words
A package as claimed in claim 4 wherein the metal is aluminum foil of a thickness of at least 20μ, and the interior plastic laminate layer is a layer of a low-permeable plastic having a permeability coefficient E 1 of at the most 0.1.
Claim 7
Dependent Claim
40 words
A package as claimed in claim 5 wherein the low-permeability plastic layer is a 20-80μ layer of an acrylonitrile copolymer having a permeability coefficient E 1 of 0.01 and containing a proportion of acrylonitrile of about 72 percent by weight.
Claim 8
Dependent Claim
26 words
A package as claimed in claim 5 wherein the low-permeability plastic layer is a layer of polyvinylidene chloride having a permeability coefficient E 1 of 0.005.
Claim 9
Dependent Claim
21 words
A package as claimed in claim 5 wherein the outside of the aluminum foil is laminated with a 10-20μ polyester layer.
Claim 10
Dependent Claim
24 words
A package as claimed in claim 1 wherein the reference liquid contains a coloring component showing maximum or significant absorption at about 500 nm.
Claim 11
Dependent Claim
43 words
A package as claimed in claim 1 wherein the reference liquid contains oxygen reversibly contained in an emulsified or suspended non-water soluble organic substance selected from a silicone oil, a silicone rubber, a perfluorinated hydrocarbon compound, and a compound containing perfluorinated hydrocarbon groups.
Claim 12
Dependent Claim
21 words
A package as claimed in claim 10 wherein the emulsified or suspended phase constitutes 20 - 50% of the total volume.
Claim 13
Dependent Claim
18 words
A package as claimed in claim 10 wherein the reference liquid contains oxygen reversibly contained in perfluorotributyl amine.
Claim 14
Dependent Claim
42 words
A package as claimed in claim 1 wherein the reference liquid contains oxygen reversibly contained in an oxygen complex-forming organic substance in which the stability constant of the oxygen complex is in the range of 10 3 - 10 5 .5 .
Claim 15
Dependent Claim
74 words
A process for preparing a package as claimed in claim 1 comprising equilibrating a buffer liquid with a gas mixture containing carbon dioxide oxygen, and an inert gas, the total gas pressure at equilibration being at the most 600 mm Hg at 37° C., and thereafter transferring the equilibrated liquid under gas-tight conditions and without contact with any gas phase into flexible, gas-tight containers without the presence of any gas phase in the containers.
References Cited (Backward Citations)
US1970193A
Cited
US3380929A
Cited
US3615709A
Cited
US3681255A
Cited
US3922363A
Cited
GB1343870A
Cited
US3874850A
Cited
DE2236909A1
Cited
US3864084A
Cited
GB1444713A
Cited
US3892058A
Cited
US3922473A
Cited
US3859049A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-09-25 | 1982-03-27 | 1982-09-26 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-09-25 | 1986-03-27 | 1986-09-26 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-09-25 | 1990-03-27 | 1990-09-26 | $7700.00 | Window Closed / Lapsed |