Patent US4107288A successfully refreshed from Google Patents.
US4107288A
Expired / Lapsed
US
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Injectable compositions, nanoparticles useful therein, and process of manufacturing same
Assignee: Pharmaceutical Society of Victoria
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Filing: 1975-09-09
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Granted: 1978-08-15
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Expires: 1995-09-09
Abstract
Abstract Particles in the size range from about 10 to about 1000 nm, preferably less than about 500 nm, which comprise a crosslinked matrix of macromolecules of natural origin.
Inventors
- 👤 Richard Charles Oppenheim
- 👤 Jennifer Joy Marty
- 👤 Peter Speiser
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 16:58
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/48; A61K9/50; A61K9/51; A61K9/5107; A61K9/513; A61K9/5169; A61K9/5192; B; B01; B01J; B01J13/00; B01J13/02; B01J13/06; B01J13/08; Y; Y10; Y10S; Y10S977/00; Y10S977/70; Y10S977/773; Y10S977/775; Y10S977/778; Y10S977/783; Y10S977/902; Y10S977/904; Y10S977/915; Y10T; Y10T428/00; Y10T428/29; Y10T428/2982; Y10T428/2984; Y10T428/2989
Claims Analysis
Total Claims: 19
Claim 1
Independent Claim
93 words
A process of manufacturing particles in the size range from about 10 to about 1000 nanometres which particles comprise a crosslinked matrix of macromolecules of natural origin, which method consists essentially of: (a) solvating the macromolecules to form a thermally equilibrated clear solution; (b) treating said solution with a desolvating agent until the macromolecules have reached the desolvation region which is the region at which the intensity of scattered light is markedly increased, but before the point at which the solution becomes turbid; and, (c) adding an aldehyde hardening agent to the mixture.
Claim 2
Dependent Claim
93 words
A process of manufacturing particles in the size range from about 10 to about 1000 nanometres which particles comprise a crosslinked matrix of macromolecules of natural origin, which method consists essentially of: (a) solvating the macromolecules to form a thermally equilibrated clear solution; (b) treating said solution with a desolvating agent until the macromolecules have reached the desolvation region which is the region at which the intensity of scattered light is markedly increased, but before the point at which the solution becomes turbid; and, (c) adding an aldehyde hardening agent to the mixture.
Claim 3
Dependent Claim
26 words
A process according to claim 1, wherein a biologically or pharmacodynamically active material is added during or after any of the steps a), b) or c).
Claim 4
Dependent Claim
43 words
A process according to claim 2, wherein the desolvating region is reached by adding a slight excess of polyvalent anion or polyvalent cation and then adding a small amount of an alcohol, and wherein the active material is added dissolved in the alcohol.
Claim 5
Dependent Claim
17 words
A process according to claim 1, wherein the macromolecule is gelatin and the hardening agent is glutaraldehyde.
Claim 6
Dependent Claim
23 words
A process according to claim 1, wherein the desolvating agent is chosen from the group consisting of polyvalent anions, polyvalent cations and alcohols.
Claim 7
Dependent Claim
32 words
A process according to claim 1, wherein the desolvating region is reached by adding a slight excess of polyvalent anion or polyvalent cation and then adding a small amount of an alcohol.
Claim 8
Dependent Claim
18 words
A process according to claim 1, wherein excess hardening agent is removed from the mixture by chemical reaction.
Claim 9
Dependent Claim
17 words
A process according to claim 7, wherein the excess aldehyde is removed by reaction with a sulphite.
Claim 10
Dependent Claim
34 words
Particles in the size range from about 10 to about 1000 nanometres which particles comprise a crosslinked matrix of macromolecules of natural origin, said particles having been formed by the process of claim 1.
Claim 11
Dependent Claim
15 words
Particles according to claim 1 in the range from about 10 to about 500 nanometres.
Claim 12
Dependent Claim
34 words
Particles according to claim 1, wherein the matrix of macromolecules of natural origin is selected from the group consisting of serum albumin, collagen, casein, insulin, gum arabic, cellulose derivatives, rosin, zein and mixtures thereof.
Claim 13
Dependent Claim
10 words
Particles according to claim 11 wherein the aldehyde is glutaraldehyde.
Claim 14
Dependent Claim
12 words
Particles according to claim 12 wherein the matrix of macromolecules is gelatin.
Claim 15
Dependent Claim
12 words
Particles according to claim 1, wherein the matrix of macromolecules is gelatin.
Claim 16
Dependent Claim
13 words
An injectable composition comprising the particles of claim 9 in a fluid carrier.
Claim 17
Dependent Claim
23 words
Particles according to claim 1, wherein the particles comprise a biologically or pharmacodynamically active material supported on or incorporated into the crosslinked matrix.
Claim 18
Dependent Claim
28 words
Particles according to claim 16, wherein the active material is selected from the group consisting of phenobarbitone, diazepam, antidepressants, prednisolone phosphate, sodium salicylate, steroids, hormones, atropine and prostaglandins.
Claim 19
Dependent Claim
13 words
An injectable composition comprising the particles of claim 16, in a fluid carrier.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-08-14 | 1982-02-13 | 1982-08-15 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-08-14 | 1986-02-13 | 1986-08-15 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-08-14 | 1990-02-13 | 1990-08-15 | $7700.00 | Window Closed / Lapsed |