Patent US4097234A successfully refreshed from Google Patents.
US4097234A
Expired / Lapsed
US
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Method for preparing dispersion of collagen fiber
Assignee: Nippi Inc
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Filing: 1976-12-10
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Granted: 1978-06-27
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Expires: 1996-12-10
Abstract
Abstract A method for preparing an aqueous dispersion of collagen fibers from various materials containing insoluble collagen and various products prepared from the dispersion are disclosed.
Inventors
- 👤 Takeshi Sohde
- 👤 Astuko Gotoh
- 👤 Kuniharu Iwamoto
- 👤 Yasushi Okamoto
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 14:38
CPC Classifications
D; D21; D21H; D21H13/00; D21H13/10; D21H13/28; D21H13/34; A; A61; A61L; A61L15/00; A61L15/16; A61L15/22; A61L15/32; A61L15/325; A61L27/00; A61L27/14; A61L27/22; A61L27/24; A63; A63B; A63B51/00; A63B51/02; B; B01; B01D; B01D71/00; B01D71/06; B01D71/74; D01; D01F; D01F4/00; D21H5/00; D21H5/12; D21H5/1209; A61F; A61F2310/00; A61F2310/00005; A61F2310/00365; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/842
Claims Analysis
Total Claims: 10
Claim 1
Independent Claim
170 words
A method of preparing an aqueous dispersion of collagen fibers which comprises: (a) soaking a material including bundles of collagen fibers in an aqueous solution 0.3 to 1.0 normal with respect to NaOH, and containing 10% to 20% Na 2 SO 4 by weight and 0.05 to 0.3 mole per liter of an organic base until a portion of the telpeptides is removed from the collagen molecules in said bundles, (1) said bundles having a length greater than 5 mm when being soaked in said solution, (2) a length of said bundles greater than 5 mm being maintained during said soaking; (b) washing the soaked material with water; (c) grinding the washed material until said fiber bundles have a length of 5 to 70 mm; (d) tanning the ground fiber bundles; and (e) comminuting the tanned fiber bundles in an aqueous medium at a pH of 2.0 - 4.0 or 9.0 to 11.0 until an aqueous dispersion of collagen fibers having a length of at least 2 mm is formed.
Claim 2
Independent Claim
170 words
A method of preparing an aqueous dispersion of collagen fibers which comprises: (a) soaking a material including bundles of collagen fibers in an aqueous solution 0.3 to 1.0 normal with respect to NaOH, and containing 10% to 20% Na 2 SO 4 by weight and 0.05 to 0.3 mole per liter of an organic base until a portion of the telpeptides is removed from the collagen molecules in said bundles, (1) said bundles having a length greater than 5 mm when being soaked in said solution, (2) a length of said bundles greater than 5 mm being maintained during said soaking; (b) washing the soaked material with water; (c) grinding the washed material until said fiber bundles have a length of 5 to 70 mm; (d) tanning the ground fiber bundles; and (e) comminuting the tanned fiber bundles in an aqueous medium at a pH of 2.0 - 4.0 or 9.0 to 11.0 until an aqueous dispersion of collagen fibers having a length of at least 2 mm is formed.
Claim 3
Dependent Claim
25 words
A method according to claim 1 wherein said soaking is carried out at a temperature of 0° - 37° C for 1 - 7 days.
Claim 4
Dependent Claim
15 words
A method according to claim 2 wherein said temperature ranges from 25° - 35° C.
Claim 5
Dependent Claim
25 words
A method according to claim 1 wherein said organic base is a primary or secondary amine having 1 - 5 carbon atoms, hydrazine or hydroxylamine.
Claim 6
Dependent Claim
21 words
A method according to claim 1 wherein said organic base is selected from the group consisting of hydroxylamine, monomethylamine and dimethylamine.
Claim 7
Dependent Claim
23 words
A method according to claim 1 wherein said grinding step is carried out by the sequential use of a mincer and a homogenizer.
Claim 8
Dependent Claim
41 words
A method as set forth in claim 1, wherein said ground fiber bundles are tanned by means of a tanning agent selected from the group consisting of formaldehyde, acetaldehyde, glyoxal, glutaraldehyde, chromium complex salt, aluminum sulfate, ferric sulfate, and smoke liquid.
Claim 9
Dependent Claim
19 words
A method as set forth in claim 1, wherein said tanned fiber bundles are comminuted in a dispersing mill.
Claim 10
Dependent Claim
38 words
A method as set forth in claim 1, wherein said tanned fiber bundles are comminuted until the collagen fibers in said dispersion have a diameter of 4 to 12 μ and a length of 2 to 25 mm.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-06-26 | 1981-12-26 | 1982-06-27 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-06-26 | 1985-12-26 | 1986-06-27 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-06-26 | 1989-12-26 | 1990-06-27 | $7700.00 | Window Closed / Lapsed |