Patent US4080966A successfully refreshed from Google Patents.
US4080966A
Expired / Lapsed
US
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Automated infusion apparatus for blood pressure control and method
Assignee: University of Pennsylvania
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Filing: 1976-08-12
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Granted: 1978-03-28
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Expires: 1996-08-12
Abstract
Abstract A reliable and inexpensive method has been developed to continually regulate the blood pressure of mammals at virtually any desired level. The pressure thus regulated may be maintained within 10 mm Hg tolerances. The method may be carried out by a closed loop apparatus with which (1) the actual blood pressure is continually measured, (2) a function of the actual blood pressure is compared with a desired blood pressure, (3) any difference between the blood pressure expressed by the function of the actual blood pressure and the desired blood pressure is converted into an error signal, (4) the error signal is converted into proportional and derivative functions which in turn (5) control the rate of pumping of a supply of a liquid hypertensive agent or a hypotensive agent into the circulatory system of the mammal.
Inventors
- 👤 Robert T. McNally
- 👤 Karl Engelman
- 👤 Abraham Noordergraaf
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 07:47
CPC Classifications
A; A61; A61M; A61M5/00; A61M5/14; A61M5/168; A61M5/172; A61M5/1723; A61B; A61B5/00; A61B5/02; A61B5/021; A61B5/72; A61B5/7235; A61B5/7239; G; G05; G05D; G05D16/00; G05D16/20; G05D16/2006; G05D16/2066; Y; Y10; Y10S; Y10S128/00; Y10S128/13
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
94 words
Apparatus for infusing drugs into a patient to achieve a desired blood pressure level comprising: means for developing a representation of said desired level; transducer means for evaluating the present blood pressure of the subject, and for developing a signal in correspondence therewith; control means, responsive to the difference between said representation of said desired pressure and the signal in correspondence with said present pressure, and to the derivative of said difference, for developing an infusion control signal; and pump means, responsive to said infusion control signal, for injecting said drugs into the patient.
Claim 2
Dependent Claim
94 words
Apparatus for infusing drugs into a patient to achieve a desired blood pressure level comprising: means for developing a representation of said desired level; transducer means for evaluating the present blood pressure of the subject, and for developing a signal in correspondence therewith; control means, responsive to the difference between said representation of said desired pressure and the signal in correspondence with said present pressure, and to the derivative of said difference, for developing an infusion control signal; and pump means, responsive to said infusion control signal, for injecting said drugs into the patient.
Claim 3
Dependent Claim
156 words
Apparatus for infusing drugs into a patient to achieve a desired blood pressure level comprising: means for developing a representation of said desired level; transducer means for evaluating the present blood pressure of the subject, and for developing a signal in correspondence therewith; control means, responsive to the difference between said representation of said desired pressure and the signal in correspondence with said present pressure, and to the derivative of said difference, for developing an infusion control signal; pump means, responsive to said infusion control signal, for injecting said drugs into the subject; and wherein said transducer means includes filter means for developing a signal representative of mean arterial pressure, said control means operating responsively to the difference between said representation of said desired pressure and said signal representative of mean arterial pressure, and to the derivative of said difference between said representation of said desired pressure and said signal representative of said mean arterial pressure.
Claim 4
Dependent Claim
156 words
Apparatus for infusing drugs into a patient to achieve a desired blood pressure level comprising: means for developing a representation of said desired level; transducer means for evaluating the present blood pressure of the subject, and for developing a signal in correspondence therewith; control means, responsive to the difference between said representation of said desired pressure and the signal in correspondence with said present pressure, and to the derivative of said difference, for developing an infusion control signal; pump means, responsive to said infusion control signal, for injecting said drugs into the subject; and wherein said transducer means includes filter means for developing a signal representative of mean arterial pressure, said control means operating responsively to the difference between said representation of said desired pressure and said signal representative of mean arterial pressure, and to the derivative of said difference between said representation of said desired pressure and said signal representative of said mean arterial pressure.
Claim 5
Dependent Claim
22 words
Apparatus as described in claim 2, wherein said filter means includes means for integrating the evaluated present blood pressure from said transducer.
Claim 6
Dependent Claim
146 words
Apparatus for infusing drugs into a patient to achieve a desired blood pressure level comprising: transducer means for evaluating the present blood pressure of the subject; control means, responsive to the difference between said desired pressure and said present pressure, and to the derivative of said difference, for developing an infusion control signal; and pump means, responsive to said infusion control signal, for injecting said drugs into the subject; wherein said control means comprises means for developing a reference signal corresponding to said desired pressure level; means for developing an error signal between said reference signal and a signal from said transducer means repesentative of present blood pressure; means for scaling said error signal by a predetermined factor; means for evaluating the rate of change of said error signal; and said pump means being responsive to said rate of change and to the scaled error signal.
Claim 7
Dependent Claim
146 words
Apparatus for infusing drugs into a patient to achieve a desired blood pressure level comprising: transducer means for evaluating the present blood pressure of the subject; control means, responsive to the difference between said desired pressure and said present pressure, and to the derivative of said difference, for developing an infusion control signal; and pump means, responsive to said infusion control signal, for injecting said drugs into the subject; wherein said control means comprises means for developing a reference signal corresponding to said desired pressure level; means for developing an error signal between said reference signal and a signal from said transducer means repesentative of present blood pressure; means for scaling said error signal by a predetermined factor; means for evaluating the rate of change of said error signal; and said pump means being responsive to said rate of change and to the scaled error signal.
Claim 8
Dependent Claim
31 words
Apparatus as described in claim 4 wherein said control means further includes means for combining and for amplitude scaling the combination of said rate of change and said scaled error signal.
Claim 9
Dependent Claim
82 words
In a closed loop drug infusion system for controlling a subject's measured blood pressure to a specified desired pressure, an improvement comprising: means for developing measured pressure and the desired pressure; means for integrating measured blood pressure to mean arterial pressure; means for comparing said mean arterial pressure with the desired pressure, control being based on the results of said comparing; and control means, responsive to said means for comparing, for regulating drug infusion based on a proportional plus derivative control mode.
Claim 10
Dependent Claim
82 words
In a closed loop drug infusion system for controlling a subject's measured blood pressure to a specified desired pressure, an improvement comprising: means for developing measured pressure and the desired pressure; means for integrating measured blood pressure to mean arterial pressure; means for comparing said mean arterial pressure with the desired pressure, control being based on the results of said comparing; and control means, responsive to said means for comparing, for regulating drug infusion based on a proportional plus derivative control mode.
Claim 11
Independent Claim
75 words
A method of controlling infusion of drugs into a subject to bring present blood pressure to a desired pressure level comprising the steps of: evaluating said present pressure and said desired pressure; evaluating the error between the present pressure and the desired pressure; developing a control signal based on said error and on the time rate of change of said error; and regulating the infusion of drugs in response to changes in said control signal.
Claim 12
Independent Claim
75 words
A method of controlling infusion of drugs into a subject to bring present blood pressure to a desired pressure level comprising the steps of: evaluating said present pressure and said desired pressure; evaluating the error between the present pressure and the desired pressure; developing a control signal based on said error and on the time rate of change of said error; and regulating the infusion of drugs in response to changes in said control signal.
Claim 13
Independent Claim
112 words
A method of controlling infusion of drugs into a subject to bring present blood pressure to a desired pressure level comprising the steps of: evaluating said present pressure and said desired pressure; evaluating the error between the present pressure and the desired pressure; developing a control signal based on said error and on the time rate of change of said error; regulating the infusion of drugs in response to changes in said control signal; sensing the present blood pressure of the subject; filtering the sensed present pressure to produce a representation of mean arterial pressure; and comparing said representation with the desired pressure level, thereby producing a signal representative of said error.
Claim 14
Independent Claim
112 words
A method of controlling infusion of drugs into a subject to bring present blood pressure to a desired pressure level comprising the steps of: evaluating said present pressure and said desired pressure; evaluating the error between the present pressure and the desired pressure; developing a control signal based on said error and on the time rate of change of said error; regulating the infusion of drugs in response to changes in said control signal; sensing the present blood pressure of the subject; filtering the sensed present pressure to produce a representation of mean arterial pressure; and comparing said representation with the desired pressure level, thereby producing a signal representative of said error.
Claim 15
Dependent Claim
17 words
A method as described in claim 8 wherein said filtering step includes integrating the sensed present pressure.
Claim 16
Independent Claim
82 words
The method of controlling the blood pressure of a mammal which comprises the steps of: (a) establishing a certain desired blood pressure; (b) continuously sensing the mean arterial blood pressure of said mammal; (c) continuously evaluating the difference between sensed mean arterial blood pressure and said desired pressure; (d) continuously administering intravenously a drug effective to alter said mammal's blood pressure in response to said difference in accordance with the following control relationship, ##EQU2## where A and B are predetermined scaling factors.
Claim 17
Independent Claim
82 words
The method of controlling the blood pressure of a mammal which comprises the steps of: (a) establishing a certain desired blood pressure; (b) continuously sensing the mean arterial blood pressure of said mammal; (c) continuously evaluating the difference between sensed mean arterial blood pressure and said desired pressure; (d) continuously administering intravenously a drug effective to alter said mammal's blood pressure in response to said difference in accordance with the following control relationship, ##EQU2## where A and B are predetermined scaling factors.
References Cited (Backward Citations)
US2690178A
Cited
US3143111A
Cited
US3163176A
Cited
US3319623A
Cited
US3651806A
Cited
US3938506A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1981-03-27 | 1981-09-26 | 1982-03-28 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1985-03-27 | 1985-09-26 | 1986-03-28 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1989-03-27 | 1989-09-26 | 1990-03-28 | $7700.00 | Window Closed / Lapsed |