US4056673A
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Phosphonoacetic acid derivatives of nucleosides
Assignee: Hoffmann La Roche Inc
•
Filing: 1976-07-16
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Granted: 1977-11-01
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Expires: 1996-07-16
Abstract
Abstract Phosphonoacetic acid derivatives of purine and pyrimidine nucleosides are novel antiviral and/or antineoplastic agents.
Inventors
- 👤 Edgar Philip Heimer
- 👤 Alexander Leopold Nussbaum
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 11:37
CPC Classifications
C; C07; C07H; C07H19/00; C07H19/02; C07H19/04; C07H19/06; C07H19/10; C07H19/16; C07H19/20
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
64 words
A compound of the formula ##STR13## wherein B is selected from (a) the group of nucleobases consisting of adenine, guanine, cytidine, thymidine and uracil or (b) a 5-halopyrimidine; X is hydrogen, hydroxy, or ##STR14## Y is hydrogen or ##STR15## and Z is ##STR16## or, when either of X and Y is other than hydrogen or hydroxy, is hydrogen: and pharmaceutically acceptable base salts thereof.
Claim 2
Dependent Claim
64 words
A compound of the formula ##STR13## wherein B is selected from (a) the group of nucleobases consisting of adenine, guanine, cytidine, thymidine and uracil or (b) a 5-halopyrimidine; X is hydrogen, hydroxy, or ##STR14## Y is hydrogen or ##STR15## and Z is ##STR16## or, when either of X and Y is other than hydrogen or hydroxy, is hydrogen: and pharmaceutically acceptable base salts thereof.
Claim 3
Dependent Claim
18 words
The compound of claim 1 wherein B is a nucleobase consisting of adenine, guanine, cytidine, thymidine and uracil.
Claim 4
Dependent Claim
8 words
The compound of claim 2 which is adenosine-5'-mono-carboxymethylphosphonate.
Claim 5
Dependent Claim
8 words
The compound of claim 2 which is 2'-deoxyadenosine-5'-mono-carboxymethylphosphonate.
Claim 6
Dependent Claim
8 words
The compound of claim 2 which is guanosine-5'-mono-carboxymethylphosphonate.
Claim 7
Dependent Claim
8 words
The compound of claim 2 which is adenosine-2'(3')-5'-bis-(carboxymethylphosphonate).
Claim 8
Dependent Claim
8 words
The compound of claim 2 which is arabinoadenosine-5'-mono-carboxymethylphosphonate.
Claim 9
Dependent Claim
8 words
The compound of claim 2 which is thymidine-5'-mono-carboxymethylphosphonate.
Claim 10
Dependent Claim
8 words
The compound of claim 2 which is uridine-5'-mono-carboxymethylphosphonate.
Claim 11
Dependent Claim
10 words
The compound of claim 1 wherein B is a 5'-halopyrimidine.
Claim 12
Dependent Claim
8 words
The compound of claim 10 which is 5-fluoro-2'-deoxyuridine-5'-mono-carboxymethylphosphonate.
Claim 13
Dependent Claim
8 words
The compound of claim 10 which is 5-ioso-2'-deoxyuridine-5'-mono-carboxymethylphosphonate.
Claim 14
Dependent Claim
8 words
The compound of claim 10 which is 5-bromo-2'-deoxyuridine-5'-mono-carboxymethylphosphonate.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-31 | 1981-05-02 | 1981-11-01 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-31 | 1985-05-02 | 1985-11-01 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-31 | 1989-05-02 | 1989-11-01 | $7700.00 | Window Closed / Lapsed |