Patent US4054736A successfully refreshed from Google Patents.
US4054736A
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Clathrate compounds of prostaglandins or their analogues with cyclodextrin
Assignee: Ono Pharmaceutical Co Ltd
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Filing: 1973-12-05
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Granted: 1977-10-18
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Expires: 1993-12-05
Abstract
Abstract Clathrate compounds of prostaglandins or their analogues with cyclodextrins and a method of manufacture thereof. The compounds are useful as labor inducing agents, contraceptives, hypotensives and remedies for ulcers and asthma.
Inventors
- 👤 Masaki Hayashi
- 👤 Atsunobu Ishihara
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:14
CPC Classifications
A; A61; A61K; A61K47/00; A61K47/50; A61K47/69; A61K47/6949; A61K47/6951; A61K31/00; A61K31/557; B; B82; B82Y; B82Y5/00; C; C07; C07C; C07C405/00; C07C405/0008; C07C405/0025; C08; C08B; C08B37/00; C08B37/0006; C08B37/0009; C08B37/0012; C08B37/0015
Claims Analysis
Total Claims: 26
Claim 1
Independent Claim
22 words
A cyclodextrin clathrate compound of a prostaglandin having the structure: ##STR27## and C and D are each hydrogen or --CH 3 .
Claim 2
Dependent Claim
22 words
A cyclodextrin clathrate compound of a prostaglandin having the structure: ##STR27## and C and D are each hydrogen or --CH 3 .
Claim 3
Dependent Claim
15 words
The clathrate compound of claim 1 in which the compound is PGE 1 cyclodextrin clathrate.
Claim 4
Dependent Claim
16 words
The clathrate compound of claim 1 in which the compound is PGE 1 α cyclodextrin clathrate.
Claim 5
Dependent Claim
15 words
The clathrate compound of claim 1 in which the compound is PGA 1 cyclodextrin clathrate.
Claim 6
Dependent Claim
16 words
The clathrate compound of claim 1 in which the compound is 15-methyl PGE 1 cyclodextrin clathrate.
Claim 7
Dependent Claim
17 words
The clathrate compound of claim 1 in which the compound is 16-methyl PGE 1 (B) cyclodextrin clathrate.
Claim 8
Dependent Claim
17 words
The clathrate compound of claim 1 in which the compound is 17-methyl PGE 1 (B) cyclodextrin clathrate.
Claim 9
Dependent Claim
14 words
The clathrate compound of claim 1, in which the cyclodextrin is α-, β-, γ-cyclodextrin.
Claim 10
Dependent Claim
12 words
The clathrate compound of claim 8 in which the cyclodextrin is α-cyclodextrin.
Claim 11
Dependent Claim
12 words
The clathrate compound of claim 8, in which the cyclodextrin is β-cyclodextrin.
Claim 12
Dependent Claim
13 words
The clathrate compound of claim 8 in which the cyclodextrin is γ cyclodextrin.
Claim 13
Dependent Claim
10 words
Clathrate compound of prostaglandins or their analogs with α- cyclodextrin.
Claim 14
Dependent Claim
10 words
Clathrate compound of prostaglandins or their analogs with α- cyclodextrin.
Claim 15
Dependent Claim
9 words
Clathrate compounds of prostaglandins or their analogs with β-cyclodextrin.
Claim 16
Dependent Claim
9 words
Clathrate compounds of prostaglandins or their analogs with β-cyclodextrin.
Claim 17
Dependent Claim
9 words
Clathrate compounds of prostaglandins or their analogs with γ-cyclodextrin.
Claim 18
Dependent Claim
9 words
Clathrate compounds of prostaglandins or their analogs with γ-cyclodextrin.
Claim 19
Dependent Claim
26 words
The clathrate compound of claim 12 in which the prostaglandins or their analogs are selected from the group consisting o PGE 2 and PGE 1 alcohol.
Claim 20
Dependent Claim
94 words
The clathrate compounds of claim 13 in which the prostaglandins or their analogs are selected from the group consisting of PGA 1 , PGA 2 , PGA 2 -decyl ester, PGE 1 , PGE 1 alcohol, PGE 1 - decyl ester, α-methyl-PGE 1 , 15-methyl-PGE 1 , 16-methyl-PGE 1 (B), 17-methyl-PGE 1 (B), PGE 2 , PGE 2 -decyl ester, α-methyl PGE 2 , 15-methyl-PGE 2 (B), 16-methyl-PGE 2 (B), 17-methyl-PGE 2 (B), 16-methyl-PGE 2 (B)-decyl ester, 16-methyl-PGE 2 (B) alcohol, PGE 2 -9-carboethoxynonyl ester, PGF 1 α, PGF 2 α and PG 234.
Claim 21
Dependent Claim
26 words
The clathrate compounds of claim 14 in which the prostaglandins or their analogs are selected from the group consisting of PGE 2 and PGE 1 alcohol.
Claim 22
Dependent Claim
29 words
A pharmaceutical composition which comprises a clathrate compound of prostaglandin or its analog with cyclodextrin, in which the cyclodextrin is α-, β-, or γ-cyclodextrin, and a pharmaceutically acceptable carrier.
Claim 23
Dependent Claim
29 words
A pharmaceutical composition which comprises a clathrate compound of prostaglandin or its analog with cyclodextrin, in which the cyclodextrin is α-, β-, or γ-cyclodextrin, and a pharmaceutically acceptable carrier.
Claim 24
Dependent Claim
12 words
The pharmaceutical composition of claim 18 in which the cyclodextrin is α-cyclodextrin.
Claim 25
Dependent Claim
12 words
The pharmaceutical composition of claim 18 in which the cyclodextrin is β-cyclodextrin.
Claim 26
Dependent Claim
12 words
The pharmaceutical compositions of claim 18 in which the cyclodextrin is γ-cyclodextrin.
References Cited (Backward Citations)
US3816393A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-10-17 | 1981-04-18 | 1981-10-18 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-10-17 | 1985-04-18 | 1985-10-18 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-10-17 | 1989-04-18 | 1989-10-18 | $7700.00 | Window Closed / Lapsed |