Patent US4025618A successfully refreshed from Google Patents.
US4025618A
Expired / Lapsed
US
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Method for separation of cryoprecipitate from blook plasma
Assignee: Baxter International Inc
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Filing: 1976-03-29
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Granted: 1977-05-24
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Expires: 1996-03-29
Abstract
Abstract A blood collection system which comprises several blood compatible sealed bags connected together by blood compatible conduits. Means for separating cryoprecipitate from blood plasma are provided. This separation is made by a filtering means. The filtering means is positioned in the outlet of one of the bags of the system. After the blood cells have been removed by a prior step, the remaining blood plasma is collected in the bag which has the filtering means in the outlet. In this bag, the blood plasma is frozen and then slowly thawed. Factor VIII rich cryoprecipitate forms in this bag as part of the freezing and thawing process. As the plasma melts, it flows from the bag through the filtering means. The filtering means positioned in the outlet of the bag retains the cryoprecipitate. Thus, the separation of Factor VIII rich cryoprecipitate from the blood plasma is effected.
Inventors
- 👤 Jan W. Garber
- 👤 De Wayne G. Davisson
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 09:17
CPC Classifications
C; C07; C07K; C07K14/00; C07K14/435; C07K14/745; C07K14/755; A; A61; A61M; A61M1/00; A61M1/02; A61M1/0209; A61M1/0218; A61M1/36; A61M1/369; B; B01; B01D; B01D35/00; A61M2202/00; A61M2202/04; A61M2202/0413; A61M2202/0445; A61M2202/0447; A61M2202/0452; A61M2205/00; A61M2205/36; A61M2205/3606; A61M2205/75; A61M2205/7545; A61M39/00; A61M39/22; A61M39/221; Y; Y10; Y10S; Y10S530/00; Y10S530/827; Y10S530/829; Y10S530/83
Claims Analysis
Total Claims: 11
Claim 1
Independent Claim
109 words
In the method of blood collection which comprises passing blood plasma containing Factor VIII into a blood compatible, sealed container; freezing said blood plasma within said sealed container to cause the precipitation of Factor VIII-rich cryoprecipitate; and thawing said blood plasma, the improvement comprising passing the thawed blood plasma, under conditions to prevent the substantial redissolving of said cryoprecipitate, through filtering means, said filtering means comprising a depth filter made of open-celled foam, said depth filter being positioned within said container to obstruct an outlet therefrom, whereby cryoprecipitate-poor plasma is transferred from said container through said outlet, and said cryoprecipitate is retained on the filtering means within said container.
Claim 2
Dependent Claim
109 words
In the method of blood collection which comprises passing blood plasma containing Factor VIII into a blood compatible, sealed container; freezing said blood plasma within said sealed container to cause the precipitation of Factor VIII-rich cryoprecipitate; and thawing said blood plasma, the improvement comprising passing the thawed blood plasma, under conditions to prevent the substantial redissolving of said cryoprecipitate, through filtering means, said filtering means comprising a depth filter made of open-celled foam, said depth filter being positioned within said container to obstruct an outlet therefrom, whereby cryoprecipitate-poor plasma is transferred from said container through said outlet, and said cryoprecipitate is retained on the filtering means within said container.
Claim 3
Dependent Claim
16 words
The method of claim 1 in which said open cell foam filter is made of polyurethane.
Claim 4
Dependent Claim
43 words
The method of claim 1 in which said frozen blood plasma is allowed to slowly thaw at a temperature below 20° C., while the plasma is allowed to pass through said filtering means promptly as it melts and out of said bag outlet.
Claim 5
Dependent Claim
18 words
The method of claim 1 in which said frozen blood plasma is allowed to thaw at 2°-5° C.
Claim 6
Dependent Claim
16 words
The method of claim 4 in which said open cell foam filter is made of polyurethane.
Claim 7
Dependent Claim
22 words
The method of claim 1 in which said cryoprecipitate-poor plasma is transferred to another blood-compatible sealed bag through a blood compatible conduit.
Claim 8
Dependent Claim
33 words
The method of claim 1 in which physiological saline solution is thereafter added to said second bag, to redissolve the cryoprecipitate, and said cryoprecipitate containing solution is thereafter removed from said second bag.
Claim 9
Dependent Claim
23 words
The method of claim 7 in which, after the cryoprecipitate is redissolved, any cryoprecipitate caught in the filter is removed from the filter.
Claim 10
Dependent Claim
24 words
The method of claim 8 in which the removal of cryoprecipitate from the filter is accomplished by washing the filter with a saline solution.
Claim 11
Dependent Claim
20 words
The method of claim 8 in which the removal of cryoprecipitate from the filter is accomplished by squeezing the filter.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-05-23 | 1980-11-22 | 1981-05-24 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-05-23 | 1984-11-22 | 1985-05-24 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-05-23 | 1988-11-22 | 1989-05-24 | $7700.00 | Window Closed / Lapsed |