Patent US2433889A successfully refreshed from Google Patents.
Patent US4014987A successfully refreshed from Google Patents.
US4014987A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Device for delivery of useful agent
Assignee: Alza Corp
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Filing: 1975-06-30
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Granted: 1977-03-29
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Expires: 1995-06-30
Abstract
Abstract A device for the controlled continuous administration of an active agent to an environment of use is disclosed. The device comprises a body of erodible agent release rate controlling material containing an agent dispersed therethrough; the rate controlling material is a hydrophobic poly(carboxylic acid) having one ionizable carboxylic hydrogen for each 8 to 12 carbon atoms, which material erodes at a controlled and continuous rate over a prolonged period of time in response to the environment by a process of carboxylic hydrogen ionization, thereby releasing the dispersed agent at a controlled rate over a prolonged period of time.
Inventors
- 👤 Jorge Heller
- 👤 Richard W. Baker
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 13:20
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0034; A61K9/0036
Claims Analysis
Total Claims: 18
Claim 1
Independent Claim
137 words
A device for the controlled local administration of drug to the vagina comprising a matrix or hollow body made of drug release rate controlling material formed of a hydrophobic poly(acid) represented by the formula: ##STR15## wherein the R's are organic radicals independently selected to provide on the average from 8 to 22 total carbon atoms for each carboxylic hydrogen, said body of drug release rate controlling material containing a vaginally acceptable drug dispersed therethrough, the device shaped and adapted for insertion and placement in the vagina, and wherein the release rate controlling material erodes at a controlled rate over a prolonged period of time when the device is in the vagina in response to the environment of the vagina, thereby releasing the dispersed drug to the vagina at a controlled rate over a prolonged period of time.
Claim 2
Independent Claim
137 words
A device for the controlled local administration of drug to the vagina comprising a matrix or hollow body made of drug release rate controlling material formed of a hydrophobic poly(acid) represented by the formula: ##STR15## wherein the R's are organic radicals independently selected to provide on the average from 8 to 22 total carbon atoms for each carboxylic hydrogen, said body of drug release rate controlling material containing a vaginally acceptable drug dispersed therethrough, the device shaped and adapted for insertion and placement in the vagina, and wherein the release rate controlling material erodes at a controlled rate over a prolonged period of time when the device is in the vagina in response to the environment of the vagina, thereby releasing the dispersed drug to the vagina at a controlled rate over a prolonged period of time.
Claim 3
Dependent Claim
98 words
A vaginal device for the controlled local administration of a drug to a vagina comprising a body having means shaped and adapted for insertion and placement in the vagina, the body having a wall formed of a drug release rate controlling material comprising a hydrophobic poly(carboxylic acid) having from 8 to 22 carbon atoms for each ionizable carboxylic hydrogen, a vaginally acceptable drug dispersed within the material, and wherein the release rate material erodes when the device is placed in the vagina, thereby administering drug at a controlled rate to the vagina over the prolonged period of time.
Claim 4
Dependent Claim
98 words
A vaginal device for the controlled local administration of a drug to a vagina comprising a body having means shaped and adapted for insertion and placement in the vagina, the body having a wall formed of a drug release rate controlling material comprising a hydrophobic poly(carboxylic acid) having from 8 to 22 carbon atoms for each ionizable carboxylic hydrogen, a vaginally acceptable drug dispersed within the material, and wherein the release rate material erodes when the device is placed in the vagina, thereby administering drug at a controlled rate to the vagina over the prolonged period of time.
Claim 5
Independent Claim
113 words
A device for the controlled local administration of drug to a vagina comprising a body shaped and adapted for insertion and retention in the vagina, the body having a wall formed of a drug release rate controlling material comprising a terpolymer consisting of at least one α,β -unsaturated aliphatic acid in which the alkyl group has 2 to 8 carbon atoms, a vaginally acceptable drug dispersed in the material and wherein the device when placed in the vagina the material erodes at a controlled rate over a prolonged period of time in response to the vaginal environment, thereby dispensing drug to the vagina at a controlled rate over a prolonged period of time.
Claim 6
Independent Claim
113 words
A device for the controlled local administration of drug to a vagina comprising a body shaped and adapted for insertion and retention in the vagina, the body having a wall formed of a drug release rate controlling material comprising a terpolymer consisting of at least one α,β -unsaturated aliphatic acid in which the alkyl group has 2 to 8 carbon atoms, a vaginally acceptable drug dispersed in the material and wherein the device when placed in the vagina the material erodes at a controlled rate over a prolonged period of time in response to the vaginal environment, thereby dispensing drug to the vagina at a controlled rate over a prolonged period of time.
Claim 7
Dependent Claim
30 words
The device for the controlled administration of drug to the vagina according to claim 1 wherein n has a value providing an average molecular weight of from 10,000 to 800,000.
Claim 8
Dependent Claim
23 words
The device for the controlled administration of drug to the vagina according to claim 1 wherein the drug is an antifertility progestational steroid.
Claim 9
Dependent Claim
40 words
The device for the controlled administration of drug according to claim 1 wherein the device is ring-shaped and adapted for vaginal placement, the poly(acid) is formed of polymerized n-butyl acrylate and acrylic acid, and the drug dispersed therethrough is progesterone.
Claim 10
Dependent Claim
54 words
The device for the controlled administration of drug to the vagina according to claim 1 wherein the drug is a member selected from the group consisting of pregn-4-ene-3,20-dione; 19-nor-pregn-4-en-3,20-dione; 17-hydroxy-19-nor-17 α-pregn-5(10)-3-en-20-yn-3-one; dl-11β-ethyl-17 α-ethynyl-17β-hydroxypregn-4-en-3-one; 17 α-ethynyl-17-hyroxy5(10) -estren-3-one; 17 α-ethynyl-19-norestosterone; 6-chloro-17-hydroxypregn-4,6-diene-3,20-dione; 17β-hydroxy-6 α-methyl-17-(1-propynyl) androst-4-en-3-one; 9β,10α -pregna-4,6-diene-3,20-dione; 17-hydroxy-17 pregan-4-en-20-yn-3-one; 19-nor-17 α-pregn-4-en-20-yne-3β,17-diol; 17-hydroxypregn-4-en-3,20-dione; 17 α-hydroxy-progesterone and 17-hydroxy-6 α-methyl-pregn-4-ene-3,10-dione.
Claim 11
Dependent Claim
23 words
The device for the controlled administration of drug to the vagina according to claim 1 wherein the drug is an antifertility estrogenic steriod.
Claim 12
Dependent Claim
48 words
The device for the controlled administration of drug to the vagina according to claim 1 wherein the drug is a member selected from the group consisting of β-estradiol; β-estradiol 3-benzoate; 17β-cyclopentane propionate estradiol; 1,3,5(10)-estratriene-3,17β-diol dipropionate estra-1,3,5(10)-triene-3,17-β-diol valerate; estrone; ethinyl estradiol; 17-ethinyl estradiol-3 methyl ether; 17-ethinyl estradiol-3-cyclopentoether; and estriol.
Claim 13
Dependent Claim
31 words
The vaginal device for administering drug to the vagina according to claim 2 wherein the drug is a member selected from the group consisting of penicillin, tetracycline, oxytetracycline, chlorotetracycline and chloramphenicol.
Claim 14
Dependent Claim
30 words
The vaginal device for administering drug to the vagina according to claim 3 wherein the drug is a member selected from the group consisting of prednisolone, cortisone, cortisol and triamcinolone.
Claim 15
Independent Claim
141 words
A method for controlling fertility which comprises placing in the vagina of a mammal a device shaped, sized and adapted for comfortable insertion and placement in the vagina, said device comprising a matrix made of a drug release rate controlling material formed of a hydrophobic poly(carboxylic acid) having the following formula: ##STR16## wherein the R's are organic radicals independently selected to provide on the average from 8 to 22 total carbon atoms for each carboxylic hydrogen, said matrix containing a vaginally acceptable drug selected from the group of antifertility progestational and estrogenic steroids dispersed therethrough, and wherein the device when positioned in the vagina releases drug at a controlled rate as the material erodes over a prolonged period of time in response to the environment of the vagina, thereby releasing an effective amount of steroid for controlling fertility in the animal.
Claim 16
Independent Claim
141 words
A method for controlling fertility which comprises placing in the vagina of a mammal a device shaped, sized and adapted for comfortable insertion and placement in the vagina, said device comprising a matrix made of a drug release rate controlling material formed of a hydrophobic poly(carboxylic acid) having the following formula: ##STR16## wherein the R's are organic radicals independently selected to provide on the average from 8 to 22 total carbon atoms for each carboxylic hydrogen, said matrix containing a vaginally acceptable drug selected from the group of antifertility progestational and estrogenic steroids dispersed therethrough, and wherein the device when positioned in the vagina releases drug at a controlled rate as the material erodes over a prolonged period of time in response to the environment of the vagina, thereby releasing an effective amount of steroid for controlling fertility in the animal.
Claim 17
Independent Claim
142 words
A method for controlling fertility which comprises placing in the vagina of a mammal a device shaped, sized and adapted for comfortable insertion and placement in the vagina, said device comprising a hollow body formed of a drug release rate controlling material made of a hydrophobic poly(carboxylic acid) having the following formula: ##STR17## wherein the R's are organic radicals independently selected to provide on the average from 8 to 22 total carbon atoms for each carboxylic hydrogen, said body containing a vaginally acceptable drug selected from the group of antifertility progestational and estrogenic steroids contained therein, and wherein the device when positioned in the vagina releases drug at a controlled rate as the material erodes over a prolonged period of time in response to the environment of the vagina, thereby releasing an effective amount of steroid for controlling fertility in the animal.
Claim 18
Independent Claim
142 words
A method for controlling fertility which comprises placing in the vagina of a mammal a device shaped, sized and adapted for comfortable insertion and placement in the vagina, said device comprising a hollow body formed of a drug release rate controlling material made of a hydrophobic poly(carboxylic acid) having the following formula: ##STR17## wherein the R's are organic radicals independently selected to provide on the average from 8 to 22 total carbon atoms for each carboxylic hydrogen, said body containing a vaginally acceptable drug selected from the group of antifertility progestational and estrogenic steroids contained therein, and wherein the device when positioned in the vagina releases drug at a controlled rate as the material erodes over a prolonged period of time in response to the environment of the vagina, thereby releasing an effective amount of steroid for controlling fertility in the animal.
References Cited (Backward Citations)
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-28 | 1980-09-27 | 1981-03-29 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-28 | 1984-09-27 | 1985-03-29 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-28 | 1988-09-27 | 1989-03-29 | $7700.00 | Window Closed / Lapsed |