Patent US4011307A successfully refreshed from Google Patents.
US4011307A
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US
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Production of 203 Pb-tris-hydroxymethyl amino methane
Assignee: Energy Research and Development Administration ERDA
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Filing: 1976-06-03
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Granted: 1977-03-08
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Expires: 1996-06-03
Abstract
Abstract 203 Pb-tris complex injected for use in the detection and localization of tumors. The lead-203 is produced from the deuteron bombardment of a thallium target and chemically separated from the thallium. The tris is added which complexes with the lead-203.
Inventors
- 👤 Richard M. Lambrecht
- 👤 Samuel Packer
- 👤 Jerald C. Merrill
- 👤 Harold L. Atkins
- 👤 Alfred P. Wolf
- 👤 Patrick R. Bradley-Moore
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:11
CPC Classifications
G; G21; G21H; G21H5/00; G21H5/02; A; A61; A61K; A61K51/00; A61K51/02; A61K51/04; A61K51/0474; A61K51/0478; G21G; G21G1/00; G21G1/04; G21G1/10; A61K2123/00
Claims Analysis
Total Claims: 8
Claim 1
Independent Claim
145 words
The method of preparing carrier-free 203 Pb-lead tris-hydroxymethyl amino methane comprising the steps of: a. exposing a target consisting of naturally occurring thallium to a beam of deuterons of at least about 11 MeV but not in excess of 22.7 MeV energy, said target being of sufficient thickness along the path of said beam so as to cause said beam to be degraded down to about 11 MeV in the thallium, for a sufficient length of time to produce lead-203 by the reaction 203 Tl (d, 2n) 203 Pb; b. dissolving said target; c. chemically separating said 203 Pb in the form of 203 Pb-nitrate from the dissolved target; and d. dissolving the 203 Pb-nitrate in an aqueous solution of tris-hydroxymethyl amino methane, the latter being supplied in sufficient amount to adjust the solution to a pH in the range of about 6.8 to 7.2.
Claim 2
Independent Claim
145 words
The method of preparing carrier-free 203 Pb-lead tris-hydroxymethyl amino methane comprising the steps of: a. exposing a target consisting of naturally occurring thallium to a beam of deuterons of at least about 11 MeV but not in excess of 22.7 MeV energy, said target being of sufficient thickness along the path of said beam so as to cause said beam to be degraded down to about 11 MeV in the thallium, for a sufficient length of time to produce lead-203 by the reaction 203 Tl (d, 2n) 203 Pb; b. dissolving said target; c. chemically separating said 203 Pb in the form of 203 Pb-nitrate from the dissolved target; and d. dissolving the 203 Pb-nitrate in an aqueous solution of tris-hydroxymethyl amino methane, the latter being supplied in sufficient amount to adjust the solution to a pH in the range of about 6.8 to 7.2.
Claim 3
Dependent Claim
56 words
The method of claim 1 in which 203 Pb is separated from the dissolved target by adding a Fe 3 + carrier followed by precipitating out the iron compound with 203 Pb-nitrate as a coprecipitate, and then separating the 203 Pb-nitrate from the iron compound by dissolving the latter in the precipitate leaving said 203 Pb-nitrate.
Claim 4
Dependent Claim
40 words
The method of claim 2 in which the target is dissolved in sulfuric acid and the iron compound precipitated out is iron hydroxide as a result of the addition of ammonium hydroxide to the solution containing Fe 3 + carrier.
Claim 5
Dependent Claim
29 words
The tumor detection and localizing agent consisting of a sterile, carrier-free aqueous solution of lead-203 tris-hydroxymethyl amino methane having a pH in the range of about 6.8 to 7.2.
Claim 6
Dependent Claim
29 words
The tumor detection and localizing agent consisting of a sterile, carrier-free aqueous solution of lead-203 tris-hydroxymethyl amino methane having a pH in the range of about 6.8 to 7.2.
Claim 7
Independent Claim
40 words
The method of detecting and localizing a tumor such as eye melanoma comprising the step of injecting an aqueous, sterile solution of the complex, carrier-free lead-203 tris-hydroxymethyl amino methane having a pH in the range of about 6.8 to 7.2.
Claim 8
Independent Claim
40 words
The method of detecting and localizing a tumor such as eye melanoma comprising the step of injecting an aqueous, sterile solution of the complex, carrier-free lead-203 tris-hydroxymethyl amino methane having a pH in the range of about 6.8 to 7.2.
References Cited (Backward Citations)
US3957963A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1980-03-07 | 1980-09-06 | 1981-03-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1984-03-07 | 1984-09-06 | 1985-03-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1988-03-07 | 1988-09-06 | 1989-03-08 | $7700.00 | Window Closed / Lapsed |