Patent US2306073A successfully refreshed from Google Patents.
Patent US3962107A successfully refreshed from Google Patents.
US3962107A
Expired / Lapsed
US
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Enzyme-containing denture cleanser tablet
Assignee: Johnson and Johnson
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Filing: 1974-06-24
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Granted: 1976-06-08
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Expires: 1994-06-24
Abstract
Abstract A water-soluble effervescent, layered denture cleanser tablet containing one or more enzymes in one layer and one or more active oxygen compounds in the other layer and in which the enzyme layer is faster dissolving than the active oxygen layer and is substantially completely dissolved before the dissolution of the active oxygen layer reaches a level which would inactivate the enzyme.
Inventors
- 👤 Norman Arthur Levin
- 👤 Leonard Louis Kaplan
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 10:43
CPC Classifications
C; C11; C11D; C11D3/00; C11D3/0005; C11D3/0052; A; A61; A61K; A61K8/00; A61K8/02; A61K8/0216; A61K8/18; A61K8/19; A61K8/22; A61K8/30; A61K8/64; A61K8/66; A61Q; A61Q11/00; A61Q11/02; C11D17/00; C11D17/0047; C11D17/0065; C11D17/0073; C11D17/0078; C11D3/16; C11D3/38; C11D3/386; C11D3/38609; C11D3/39; C11D3/3942; A61K2800/00; A61K2800/20; A61K2800/22; A61K2800/222; A61K2800/80; A61K2800/88
Claims Analysis
Total Claims: 16
Claim 1
Independent Claim
267 words
A water-soluble effervescent layered denture cleanser tablet consisting essentially of a. an enzyme layer in an effervescence producing composition and, b. an active oxygen layer in an effervescence producing composition wherein the enzyme layer is faster dissolving than the active oxygen layer; and wherein i. said tablet contains at least one enzyme in an amount of from about 0.5 to 10 percent by weight and at least one active oxygen compound in an amount of from about 38 to 42 percent by weight, said amounts being based on the total weight of tablet, ii. in said tablet the enzyme layer is less than one-half and the active oxygen layer more than one-half of the total thickness of the tablet, iii. the effervescence producing composition in each layer of said tablet comprises an acid and an alkali metal carbonate compound, iv. the amount of said effervescence producing composition to be incorporated in said tablet is for the enzyme layer from about 75 to 90 percent of the weight of the enzyme layer and for the active oxygen layer from about 30 to 40 percent of the weight of the active oxygen layer, and v. each layer of said tablet has incorporated therein components in the form of finely divided powder of particle size of about 177 microns or less, the amounts of said powder being, for the enzyme layer from about 30 to 50 percent of the weight of the components of the enzyme layer and for the active oxygen layer from about 20 to 30 percent of the weight of the components of the active oxygen layer.
Claim 2
Dependent Claim
267 words
A water-soluble effervescent layered denture cleanser tablet consisting essentially of a. an enzyme layer in an effervescence producing composition and, b. an active oxygen layer in an effervescence producing composition wherein the enzyme layer is faster dissolving than the active oxygen layer; and wherein i. said tablet contains at least one enzyme in an amount of from about 0.5 to 10 percent by weight and at least one active oxygen compound in an amount of from about 38 to 42 percent by weight, said amounts being based on the total weight of tablet, ii. in said tablet the enzyme layer is less than one-half and the active oxygen layer more than one-half of the total thickness of the tablet, iii. the effervescence producing composition in each layer of said tablet comprises an acid and an alkali metal carbonate compound, iv. the amount of said effervescence producing composition to be incorporated in said tablet is for the enzyme layer from about 75 to 90 percent of the weight of the enzyme layer and for the active oxygen layer from about 30 to 40 percent of the weight of the active oxygen layer, and v. each layer of said tablet has incorporated therein components in the form of finely divided powder of particle size of about 177 microns or less, the amounts of said powder being, for the enzyme layer from about 30 to 50 percent of the weight of the components of the enzyme layer and for the active oxygen layer from about 20 to 30 percent of the weight of the components of the active oxygen layer.
Claim 3
Dependent Claim
63 words
A tablet according to claim 1 wherein in the enzyme layer, the enzyme is at least one selected from the group consisting of protease, alkalase, amylase, lipase, dextranase and mutanase; and in the active oxygen layer, the active oxygen compound is at least one selected from the group consisting of sodium perborate monohydrate, potassium persulfate, sodium carbonate peroxide, diperisophthalic acid and potassium peroxydiphosphate.
Claim 4
Dependent Claim
95 words
A water-soluble effervescent, layered denture cleanser tablet consisting essentially of: a. an enzyme layer prepared from an enzyme formulation comprising: 1. from about 1 to 6 percent of at least one enzyme 2. from about 75 to 90 percent of an effervescent formulation consisting essentially of i. from about 35 to 55 percent of at least one acid compound, ii. from about 50 to 60 percent of an alkali metal carbonate compound, iii. from about 0.01 to 0.1 percent of an antifoaming agent, iv. from about 0.1 to 1 percent of a water-soluble binder, and
Claim 5
Dependent Claim
95 words
A water-soluble effervescent, layered denture cleanser tablet consisting essentially of: a. an enzyme layer prepared from an enzyme formulation comprising: 1. from about 1 to 6 percent of at least one enzyme 2. from about 75 to 90 percent of an effervescent formulation consisting essentially of i. from about 35 to 55 percent of at least one acid compound, ii. from about 50 to 60 percent of an alkali metal carbonate compound, iii. from about 0.01 to 0.1 percent of an antifoaming agent, iv. from about 0.1 to 1 percent of a water-soluble binder, and
Claim 6
Dependent Claim
122 words
a mixture of from about 0.2 to 0.5 percent of magnesium lauryl sulfate and from about 0.5 to 1.5 percent of polyethylene glycol of 6000 average molecular weight as a water-soluble lubricant; and b. an active oxygen layer prepared from an active oxygen formulation comprising: 1. from about 55 to 65 percent of at least one active oxygen compound, 2. from about 35 to 45 percent of an effervescent formulation consisting essentially of i. from about 35 to 55 percent of at least one acid compound, ii. from about 50 to 60 percent of an alkali metal carbonate compound, iii. from about 0.01 to 0.1 percent of an antifoaming agent, iv. from about 0.1 to 1 percent of a water-soluble binder, and
Claim 7
Dependent Claim
122 words
a mixture of from about 0.2 to 0.5 percent of magnesium lauryl sulfate and from about 0.5 to 1.5 percent of polyethylene glycol of 6000 average molecular weight as a water-soluble lubricant; and b. an active oxygen layer prepared from an active oxygen formulation comprising: 1. from about 55 to 65 percent of at least one active oxygen compound, 2. from about 35 to 45 percent of an effervescent formulation consisting essentially of i. from about 35 to 55 percent of at least one acid compound, ii. from about 50 to 60 percent of an alkali metal carbonate compound, iii. from about 0.01 to 0.1 percent of an antifoaming agent, iv. from about 0.1 to 1 percent of a water-soluble binder, and
Claim 8
Dependent Claim
146 words
from about 0.8 to 2 percent of a surface active agent, and 4. a mixture of from about 0.4 to 1.5 percent of magnesium lauryl sulfate and from about 0.5 to 1.5 percent of polyethylene glycol of 6000 average molecular weight as water-soluble lubricant; and wherein in said tablet the enzyme layer is less than one-half and the active oxygen layer is more than one-half of the total thickness of the tablet, and wherein each layer of said tablet has incorporated therein components in the form of finely divided powder of particle size of about 177 microns or less, the amounts of said powder being for the enzyme layer from about 30 to 50 percent by weight of the components of the enzyme layer and for the active oxygen layer from about 20 to 30 percent by weight of the components of the active oxygen layer.
Claim 9
Dependent Claim
146 words
from about 0.8 to 2 percent of a surface active agent, and 4. a mixture of from about 0.4 to 1.5 percent of magnesium lauryl sulfate and from about 0.5 to 1.5 percent of polyethylene glycol of 6000 average molecular weight as water-soluble lubricant; and wherein in said tablet the enzyme layer is less than one-half and the active oxygen layer is more than one-half of the total thickness of the tablet, and wherein each layer of said tablet has incorporated therein components in the form of finely divided powder of particle size of about 177 microns or less, the amounts of said powder being for the enzyme layer from about 30 to 50 percent by weight of the components of the enzyme layer and for the active oxygen layer from about 20 to 30 percent by weight of the components of the active oxygen layer.
Claim 10
Dependent Claim
38 words
A water-soluble effervescent, layered denture cleanser tablet according to claim 3, wherein the enzyme is a protease, the acid is a citric-tartaric acid mixture, the active oxygen compound is a mixture of sodium perborate monohydrate and potassium persulfate.
Claim 11
Dependent Claim
22 words
A water-soluble, effervescent denture cleanser tablet comprising, by weight based on the weight of the final tablet: a. An enzyme layer comprising:
Claim 12
Dependent Claim
22 words
A water-soluble, effervescent denture cleanser tablet comprising, by weight based on the weight of the final tablet: a. An enzyme layer comprising:
Claim 13
Dependent Claim
161 words
a protease enzyme, from about 0.5 to about 10 percent; 2. citric acid powder, from about 4 to about 8 percent, and tartaric acid powder, from about 6 to about 10 percent; 3. sodium bicarbonate powder, from about 15 to about 20 percent; 4. dimethyl polysiloxane, from about 0.02 to about 0.1 percent; 5. polyvinylpyrrolidone, from about 0.2 to about 0.8 percent; 6. magnesium lauryl sulfate powder, from about 0.08 to about 0.2 percent, and micronized polyethylene glycol of average molecular weight of 6000, from about 0.2 to about 0.6 percent; b. An active oxygen layer containing: 1. sodium perborate monohydrate, from about 15 to 25 percent; and potassium persulfate, from about 20 to about 35 percent; 2. citric acid powder, from about 4 to about 8 percent; and tartaric acid powder, from about 6 to about 10 percent; 3. sodium bicarbonate powder from about 12 to about 20 percent; 4. sodium lauryl sulfoacetate, from about 0.055 to about 0.065 percent;
Claim 14
Dependent Claim
161 words
a protease enzyme, from about 0.5 to about 10 percent; 2. citric acid powder, from about 4 to about 8 percent, and tartaric acid powder, from about 6 to about 10 percent; 3. sodium bicarbonate powder, from about 15 to about 20 percent; 4. dimethyl polysiloxane, from about 0.02 to about 0.1 percent; 5. polyvinylpyrrolidone, from about 0.2 to about 0.8 percent; 6. magnesium lauryl sulfate powder, from about 0.08 to about 0.2 percent, and micronized polyethylene glycol of average molecular weight of 6000, from about 0.2 to about 0.6 percent; b. An active oxygen layer containing: 1. sodium perborate monohydrate, from about 15 to 25 percent; and potassium persulfate, from about 20 to about 35 percent; 2. citric acid powder, from about 4 to about 8 percent; and tartaric acid powder, from about 6 to about 10 percent; 3. sodium bicarbonate powder from about 12 to about 20 percent; 4. sodium lauryl sulfoacetate, from about 0.055 to about 0.065 percent;
Claim 15
Dependent Claim
148 words
dimethyl polysiloxane, from about 0.02 to about 0.1 percent; 6. polyvinyl pyrrolidone, from about 0.2 to about 0.8 percent; 7. magnesium lauryl sulfate powder, from about 0.15 to about 0.4 percent; and micronized polyethylene glycol (average molecular weight of 6000), from about 0.2 to about 0.6 percent; and, wherein said tablet the enzyme layer is less than one-half and the active oxygen layer is more than one-half of the total thickness of the tablet, and wherein said layer of said tablet has incorporated therein components in the form of finely divided powder of particle size of about 177 microns or less, the amounts of said powder being for the enzyme layer from about 30 to 50 percent by weight of the components of the enzyme layer and for the active oxygen layer from about 20 to 30 percent by weight of the components of the active oxygen layer.
Claim 16
Dependent Claim
148 words
dimethyl polysiloxane, from about 0.02 to about 0.1 percent; 6. polyvinyl pyrrolidone, from about 0.2 to about 0.8 percent; 7. magnesium lauryl sulfate powder, from about 0.15 to about 0.4 percent; and micronized polyethylene glycol (average molecular weight of 6000), from about 0.2 to about 0.6 percent; and, wherein said tablet the enzyme layer is less than one-half and the active oxygen layer is more than one-half of the total thickness of the tablet, and wherein said layer of said tablet has incorporated therein components in the form of finely divided powder of particle size of about 177 microns or less, the amounts of said powder being for the enzyme layer from about 30 to 50 percent by weight of the components of the enzyme layer and for the active oxygen layer from about 20 to 30 percent by weight of the components of the active oxygen layer.
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-06-08 | 1979-12-08 | 1980-06-08 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-06-08 | 1983-12-08 | 1984-06-08 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-06-08 | 1987-12-08 | 1988-06-08 | $7700.00 | Window Closed / Lapsed |