Patent US3959128A successfully refreshed from Google Patents.
US3959128A
Expired / Lapsed
US
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Process for removing endotoxin from biological fluids
Assignee: Akzona Inc
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Filing: 1974-12-27
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Granted: 1976-05-25
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Expires: 1994-12-27
Abstract
Abstract A novel process for removing endotoxin from biological fluids such as parenteral fluids and for removing or reducing the level of endotoxin from the blood of animals is disclosed. The novel process includes the utilization of certain non-ionogenic hydrophobic synthetic plastic polymers that have been found to be capable of adsorbing endotoxin from the biological fluids when placed in intimate contact therewith.
Inventors
- 👤 Nick S. Harris
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 05:01
CPC Classifications
A; A61; A61M; A61M1/00; A61M1/36; A61M1/3679; Y; Y10; Y10S; Y10S128/00; Y10S128/03
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
93 words
A process for selectively removing endotoxin derived from gram-negative bacilli from biological fluids, said process comprising: intimately contacting a biological fluid contaminated with gram-negative bacilli derived endotoxin with a non-ionogenic hydrophobic non-polar aliphatic synthetic plastic polymer selected from the group consisting of a substantially crystalline non-polar aliphatic hydrocarbon thermoplastic polymer, a substantially crystalline non-polar aliphatic thermoplastic fluorocarbon polymer, a cross-linked aliphatic silicone elastomeric polymer and mixtures thereof, whereby the endotoxin is adsorbed onto the surface of the polymer; and removing the biological fluid from contact with said polymer essentially free of said endotoxin.
Claim 2
Dependent Claim
93 words
A process for selectively removing endotoxin derived from gram-negative bacilli from biological fluids, said process comprising: intimately contacting a biological fluid contaminated with gram-negative bacilli derived endotoxin with a non-ionogenic hydrophobic non-polar aliphatic synthetic plastic polymer selected from the group consisting of a substantially crystalline non-polar aliphatic hydrocarbon thermoplastic polymer, a substantially crystalline non-polar aliphatic thermoplastic fluorocarbon polymer, a cross-linked aliphatic silicone elastomeric polymer and mixtures thereof, whereby the endotoxin is adsorbed onto the surface of the polymer; and removing the biological fluid from contact with said polymer essentially free of said endotoxin.
Claim 3
Dependent Claim
19 words
The process of claim 1 wherein said synthetic plastic polymer is a substantially crystalline non-polar aliphatic hydrocarbon thermoplastic polymer.
Claim 4
Dependent Claim
18 words
The process of claim 2 wherein said substantially crystalline non-polar aliphatic hydrocarbon thermoplastic polymer is a poly-α-olefin polymer.
Claim 5
Dependent Claim
23 words
The process of claim 3 wherein said poly-α-olefin polymer is a material selected from the group consisting of polyethylene, polypropylene and mixtures thereof.
Claim 6
Dependent Claim
19 words
The process of claim 1 wherein said synthetic plastic polymer is a substantially crystalline non-polar aliphatic thermoplastic fluorocarbon polymer.
Claim 7
Dependent Claim
34 words
The process of claim 5 wherein said substantially crystalline non-polar aliphatic thermoplastic fluorocarbon polymer is selected from the group consisting of polytetrafluoroethylene, fluoronated ethylene-propylene polymer, modified copolymer of tetrafluoroethylene and ethylene, and mixtures thereof.
Claim 8
Dependent Claim
16 words
The process of claim 1 wherein said synthetic plastic polymer is a cross-linked silicone elastomeric polymer.
Claim 9
Dependent Claim
15 words
The process of claim 7 wherein said cross-linked elastomeric silicone polymer is a cross-linked poly(alkyl-siloxane).
Claim 10
Dependent Claim
32 words
The process of claim 1 wherein said biological fluid is intimately contacted with said polymer by passing the biological fluid through a column containing the synthetic plastic polymer in a particulated form.
Claim 11
Dependent Claim
99 words
An in vivo hemoperfusion polymer-column process for removing endotoxin derived from gram-negative bacilli from the blood of an animal, said process comprising: removing blood from an animal; perfusing said blood through a column containing particles of a non-ionogenic hydrophobic non-polar aliphatic synthetic plastic polymer selected from the group consisting of a substantially crystalline non-polar aliphatic hydrocarbon thermoplastic polymer, a crystalline aliphatic thermoplastic fluorocarbon polymer, a cross-linked silicone elastomeric polymer and mixtures thereof, whereby gram-negative bacilli derived endotoxin is adsorbed onto the surface of the synthetic plastic polymer particles; and reinfusing the blood passing from said column into the animal.
Claim 12
Dependent Claim
99 words
An in vivo hemoperfusion polymer-column process for removing endotoxin derived from gram-negative bacilli from the blood of an animal, said process comprising: removing blood from an animal; perfusing said blood through a column containing particles of a non-ionogenic hydrophobic non-polar aliphatic synthetic plastic polymer selected from the group consisting of a substantially crystalline non-polar aliphatic hydrocarbon thermoplastic polymer, a crystalline aliphatic thermoplastic fluorocarbon polymer, a cross-linked silicone elastomeric polymer and mixtures thereof, whereby gram-negative bacilli derived endotoxin is adsorbed onto the surface of the synthetic plastic polymer particles; and reinfusing the blood passing from said column into the animal.
Claim 13
Dependent Claim
23 words
The process of claim 10 wherein said non-ionogenic hydrophobic non-polar aliphatic synthetic plastic polymer is a substantially crystalline non-polar aliphatic hydrocarbon thermoplastic polymer.
Claim 14
Dependent Claim
17 words
The process of claim 11 wherein said substantially crystalline non-polar aliphatic hydrocarbon thermoplastic polymer is a poly-α-olefin.
Claim 15
Dependent Claim
23 words
The process of claim 12 wherein said poly-α-olefin polymer is a polymer selected from the group consisting of polyethylene, polypropylene and mixtures thereof.
Claim 16
Dependent Claim
18 words
The process of claim 10 wherein said synthetic plastic polymer is a substantially crystalline aliphatic thermoplastic fluorocarbon polymer.
Claim 17
Dependent Claim
16 words
The process of claim 10 wherein said synthetic plastic polymer is a cross-linked silicone elastomeric polymer.
References Cited (Backward Citations)
US3794584A
Cited
US3770631A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-05-25 | 1979-11-24 | 1980-05-25 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-05-25 | 1983-11-24 | 1984-05-25 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-05-25 | 1987-11-24 | 1988-05-25 | $7700.00 | Window Closed / Lapsed |