Abstract 3-Indolyl pyridyl ketones of the general formula: ##SPC1## And pharmaceutically acceptable acid addition salts thereof wherein R 1 represents A straight- or branched-chain saturated or unsaturated alkyl group having not more than 6 carbon atoms, a benzyl group optionally substituted in the aromatic portion of a chlorine atom or a methoxy group Or ##EQU1## wherein A represents an alkylene chain of from 2 to 6 carbon atoms and R 4 and R 5 , which may be the same or different, are each an alkyl group having from 1 to 5 carbon atoms, or R 4 and R 5 are joined together to form with the nitrogen atom a piperidino, pyrrolidino or morpholino group, R 2 represents A branched- or straight-chain alkyl group having from 1 to 4 carbon atoms, a phenyl group optionally substituted by a fluorine, chlorine, or bromine atom or a methoxy or cyclohexyl group; and R 3 represents A 2-pyridyl, 3-pyridyl or 4-pyridyl group. They are effective as fibrinolytic and anti-inflammatory agents.
Inventors
👤 Margel Descamps
👤 Henri Inion
Bibliographic Details
Application Number—
JurisdictionUS
Data Sourcegoogle_patents
Last Synchronized2026-10-23 17:52
CPC Classifications
C; C07; C07D; C07D401/00; C07D401/02; C07D401/06
Claims Analysis
Total Claims: 6
Claim 1
Independent Claim
78 words
An indole derivative of the formula: ##SPC5## or a pharmaceutically acceptable acid addition salt thereof, wherein R 1 represents s straight- or branched-chain saturated alkyl having not more than 6 carbon atoms, allyl, or benzyl optionally substituted in the aromatic portion by chlorine or methoxy, R 2 represents branched- or straight-chain alkyl having from 1 to 4 carbon atoms, cyclohexyl, or phenyl optionally substituted by fluorine, chlorine, bromine or methoxy; and R 3 represents 2-pyridyl, 3-pyridyl or 4-pyridyl.
Claim 2
Dependent Claim
78 words
An indole derivative of the formula: ##SPC5## or a pharmaceutically acceptable acid addition salt thereof, wherein R 1 represents s straight- or branched-chain saturated alkyl having not more than 6 carbon atoms, allyl, or benzyl optionally substituted in the aromatic portion by chlorine or methoxy, R 2 represents branched- or straight-chain alkyl having from 1 to 4 carbon atoms, cyclohexyl, or phenyl optionally substituted by fluorine, chlorine, bromine or methoxy; and R 3 represents 2-pyridyl, 3-pyridyl or 4-pyridyl.
Claim 3
Dependent Claim
9 words
(1-methyl-2-isopropyl-3-indolyl)(3-pyridyl) ketone and pharmaceutically acceptable acid addition salts thereof.
Claim 4
Dependent Claim
9 words
(1-methyl-2-isopropyl-3-indolyl)(3-pyridyl) ketone and pharmaceutically acceptable acid addition salts thereof.
Claim 5
Dependent Claim
9 words
(1-methyl-2-isopropyl-3-indolyl)(4-pyridyl) ketone and pharmaceutically accceptable acid addition salts thereof.
Claim 6
Dependent Claim
9 words
(1-methyl-2-isopropyl-3-indolyl)(4-pyridyl) ketone and pharmaceutically accceptable acid addition salts thereof.