3-Chloro-tetrahydro-1,3-oxazines or oxazolidines spiro substituted

Abstract

Abstract There is provided, novel 3-chloro-tetrahydro 1,3-oxazine or oxazolidine compounds, exhibiting antibacterial activity and being of low chlorine potential of the formula: ##EQU1## WHEREIN EACH OF R 1 and R 2 , which may be the same or different, represent an alkyl group of from 1 to 20 carbon atoms (C 1 -C 5 being preferred); wherein each of R 5 and R 6 , which may be the same or different, represent a hydrogen atom or an alkyl group of from 1 to 20 carbon atoms (C 1 -C 5 being preferred); wherein l represents an integer of 1 or 2 and wherein each of R 3 and R 4 , which may be the same or different, represent an alkyl group of from 1 to 20 carbon atoms (C 1 -C 5 being preferred), a --(CH 2 ) n X group, wherein n represents an integer of from 1 to 20 and wherein X represents a dimethylamino group, a diethylamino group, a trimethylammonium group, a triethylammonium group, a dimethylammonium group, a diethylammonium group, a --COOR 7 group, a --OOCR 8 group, and a --OR 9 group, wherein each of R 7 through R 9 , respectively, represent an alkyl group of from 1 to 5 carbon atoms or a benzyl group. In addition, R 3 and R 4 can also represent a ##EQU2## group, wherein Y represents a --(CH 2 ) n --W--(CH 2 ) m -- group or a > CH--Z group, wherein W represents a --O-- atom, a --CH 2 -- group, a > NCH 3 -- group, a > NHCH 3 + group, a > NC 2 H 5 group, a > NHC 2 H 5 + group, a > N(CH 3 ) 2 + group, or a > N(C 2 H 5 ) 2 + group, wherein n is the same or different from m and wherein each of n and m represent an integer of from 0 to 2; and wherein Z is defined in accordance with X above.

Inventors

• 👤 Nicolae S. Bodor
• 👤 James J. Kaminski

Bibliographic Details