US3935111A — Device for removing blood microemboli

Claim 1

Independent Claim 129 words

A device for removing microemboli from whole blood or the like comprising: a casing with an interior chamber and with a flow inlet to and a flow outlet from the chamber; a plurality of effective layers of microemboli-removing material positioned in said chamber and sealed to the inner periphery of the casing to require blood flow therethrough in travel of the blood from the flow inlet to the flow outlet, said effective layers each consisting of foamed open cell polyurethane to define tortuous flow passages therethrough, said effective layers having progressively smaller effective pore sizes whereby the blood in flowing therethrough has the microemboli of a size to block passages in a layer prevented from flowing thereto by adherence to the walls of the passages in a preceding layer.

Claim 2

Independent Claim 129 words

A device for removing microemboli from whole blood or the like comprising: a casing with an interior chamber and with a flow inlet to and a flow outlet from the chamber; a plurality of effective layers of microemboli-removing material positioned in said chamber and sealed to the inner periphery of the casing to require blood flow therethrough in travel of the blood from the flow inlet to the flow outlet, said effective layers each consisting of foamed open cell polyurethane to define tortuous flow passages therethrough, said effective layers having progressively smaller effective pore sizes whereby the blood in flowing therethrough has the microemboli of a size to block passages in a layer prevented from flowing thereto by adherence to the walls of the passages in a preceding layer.

Claim 3

Dependent Claim 34 words

A device for removing microemboli from whole blood or the like as defined in claim 1 wherein the initial layer of material has an effective pore size greater than substantially all of the microemboli.

Claim 4

Independent Claim 120 words

A device for removing microemboli from whole blood or the like comprising: a casing with an interior chamber and with a flow inlet to and a flow outlet from the chamber; a plurality of layers of microemboli-removing material positioned in said chamber and sealed to the inner periphery of the casing to require blood flow therethrough in travel of the blood from the flow inlet to the flow outlet, said layers each having a plurality of tortuous passages therethrough with the effective pore size of each layer differing from the other and gradually decreasing in size from the layer closest to the flow inlet; and each of said layers of microemboli-removing material being formed of an open cell foamed plastic.

Claim 5

Independent Claim 120 words

A device for removing microemboli from whole blood or the like comprising: a casing with an interior chamber and with a flow inlet to and a flow outlet from the chamber; a plurality of layers of microemboli-removing material positioned in said chamber and sealed to the inner periphery of the casing to require blood flow therethrough in travel of the blood from the flow inlet to the flow outlet, said layers each having a plurality of tortuous passages therethrough with the effective pore size of each layer differing from the other and gradually decreasing in size from the layer closest to the flow inlet; and each of said layers of microemboli-removing material being formed of an open cell foamed plastic.

Claim 6

Dependent Claim 25 words

A device for removing microemboli from whole blood or the like as defined in claim 3 and wherein said open cell foamed plastic is polyurethane.

Claim 7

Dependent Claim 76 words

A device for removing microemboli from whole blood or the like as defined in claim 4 wherein the effective pore size of the layer of material closest to the flow inlet is larger than substantially all of the microemboli to be removed whereby said microemboli are not mechanically strained from the blood flow at the surface of said last-mentioned layer but may travel into the tortuous passages thereof and adhere to the wall of said passages.

Claim 8

Dependent Claim 56 words

A device for removing microemboli from whole blood or the like as defined in claim 5 wherein said casing includes a housing member and a base member with said members being telescopically interfitted to define said interior chamber; and said layers of material being held in position by having their peripheries mechanically captured by said members.

Claim 9

Dependent Claim 71 words

A device for removing microemboli from whole blood or the like as defined in claim 6 wherein the device is usable in blood infusion and said housing member has the flow inlet in an end thereof and said end is formed as a spike for insertion into the outlet of a blood container; and a gross filter in said interior chamber ahead of said material layers for collecting large blood clots.

Claim 10

Dependent Claim 51 words

A device for removing microemboli from whole blood or the like as defined in claim 7 wherein said gross filter is in the form of a sock; a peripheral flange on the interior of the housing member, and a retainer ring holding the top edge of said sock against said flange.

Claim 11

Dependent Claim 82 words

A device for removing microemboli from whole blood or the like as defined in claim 6 wherein said housing member and base member each has adjacent ends with a peripheral cylindrical wall and with the wall of the housing member of a smaller diameter and fitted into the wall of the base member to form said telescopic interfit; and said base member having a support of screen material underlying said layers of material and spanning the flow outlet to support said layers.

Claim 12

Dependent Claim 33 words

A device for removing microemboli from blood as defined in claim 8 including blood flow channels in the base member adjacent said screen material support to facilitate blood flow to the flow outlet.

Claim 13

Dependent Claim 36 words

A device for removing microemboli from whole blood or the like as defined in claim 9 with a bypass passage around said layers of material, and a plunger movable to a position to close said passage.

Claim 14

Independent Claim 211 words

A device for removing microemboli from whole blood or the like comprising: a casing defined by a housing member and a base member received together to define an interior chamber; an externally connectable flow inlet to the chamber in one member; an externally connectable flow outlet from the chamber in the other member; a plurality of layers of microemboli-removing material positioned in said chamber in obstructing relation to the flow path from the flow inlet to the flow outlet, said layers each consisting of foamed open cell polyurethane to define tortuous flow passages therethrough, the first layer closest to the flow inlet having an effective pore size for the passages greater than the size of substantially all microemboli to be removed from the blood whereby the microemboli may enter the passages and the largest thereof adhesively adhere to the wall thereof to prevent further flow of the largest microemboli, the successive layers of material having progressively smaller effective pore size to receive progressively smaller microemboli and cause adherence thereof to the passage walls, said smaller effective pore sizes being less than the size of microemboli retained by the previous layer of material but not being blocked thereby because of their adherence to the wall of the passages in a preceding layer.

Claim 15

Independent Claim 211 words

A device for removing microemboli from whole blood or the like comprising: a casing defined by a housing member and a base member received together to define an interior chamber; an externally connectable flow inlet to the chamber in one member; an externally connectable flow outlet from the chamber in the other member; a plurality of layers of microemboli-removing material positioned in said chamber in obstructing relation to the flow path from the flow inlet to the flow outlet, said layers each consisting of foamed open cell polyurethane to define tortuous flow passages therethrough, the first layer closest to the flow inlet having an effective pore size for the passages greater than the size of substantially all microemboli to be removed from the blood whereby the microemboli may enter the passages and the largest thereof adhesively adhere to the wall thereof to prevent further flow of the largest microemboli, the successive layers of material having progressively smaller effective pore size to receive progressively smaller microemboli and cause adherence thereof to the passage walls, said smaller effective pore sizes being less than the size of microemboli retained by the previous layer of material but not being blocked thereby because of their adherence to the wall of the passages in a preceding layer.

Claim 16

Independent Claim 136 words

A device for removing microemboli from whole blood or the like comprising: a casing defined by a housing member and a base member secured together to define an interior chamber; an externally connectable flow inlet to the chamber in one member; an externally connectable flow outlet from the chamber in the other member; a plurality of layers of microemboli-removing material positioned in said chamber in obstructing relation to the flow path from the flow inlet to the flow outlet, said layers each consisting of foamed open cell polyurethane to define tortuous flow passages therethrough, said layers having progressively smaller effective pore sizes whereby the blood in flowing therethrough has the microemboli of a size to block passages in the layer prevented from flowing thereto by adherence to the walls of the passages in a preceding layer.

Claim 17

Independent Claim 136 words

A device for removing microemboli from whole blood or the like comprising: a casing defined by a housing member and a base member secured together to define an interior chamber; an externally connectable flow inlet to the chamber in one member; an externally connectable flow outlet from the chamber in the other member; a plurality of layers of microemboli-removing material positioned in said chamber in obstructing relation to the flow path from the flow inlet to the flow outlet, said layers each consisting of foamed open cell polyurethane to define tortuous flow passages therethrough, said layers having progressively smaller effective pore sizes whereby the blood in flowing therethrough has the microemboli of a size to block passages in the layer prevented from flowing thereto by adherence to the walls of the passages in a preceding layer.

Claim 18

Dependent Claim 36 words

A device as defined in claim 13 including means defining a bypass passage around said layers of material for use in priming the device, and means movable to a locked position to close said bypass passage.

Claim 19

Dependent Claim 126 words

In a device for removing microemboli from whole blood or the like having a casing defining an interior chamber with a flow inlet and outlet; a plurality of layers of microemboli-removing material, each layer having a plurality of tortuous passageways therethrough; said layers being positioned in said chamber in obstructing relation to the flow path from said flow inlet to said flow outlet; the first of said layers closest to the flow inlet having an effective pore size greater than the size of all microemboli to be removed from the blood; the successive layers of said microemboli-removing material having progressively smaller effective pore size; said layers being formed of an open cell foamed plastic with effective pore sizes from about 150 microns to about 25 microns.

Claim 20

Dependent Claim 126 words

In a device for removing microemboli from whole blood or the like having a casing defining an interior chamber with a flow inlet and outlet; a plurality of layers of microemboli-removing material, each layer having a plurality of tortuous passageways therethrough; said layers being positioned in said chamber in obstructing relation to the flow path from said flow inlet to said flow outlet; the first of said layers closest to the flow inlet having an effective pore size greater than the size of all microemboli to be removed from the blood; the successive layers of said microemboli-removing material having progressively smaller effective pore size; said layers being formed of an open cell foamed plastic with effective pore sizes from about 150 microns to about 25 microns.

Claim 21

Dependent Claim 30 words

A device for removing microemboli from whole blood or the like according to claim 15 wherein said open cell foamed plastic forming said layers is a unitary structure of polyurethane.

Annuity Stage	Window Opens	Payment Deadline	Surcharge Period Until	Estimated Fee	Status
3.5 Years (Year 4)	1979-01-26	1979-07-28	1980-01-27	$2000.00	Window Closed / Lapsed
7.5 Years (Year 8)	1983-01-26	1983-07-28	1984-01-27	$3760.00	Window Closed / Lapsed
11.5 Years (Year 12)	1987-01-26	1987-07-28	1988-01-27	$7700.00	Window Closed / Lapsed

Device for removing blood microemboli

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