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US3931222A
Expired / Lapsed
US
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Tetrahydro-carbazole derivates
Assignee: Pfizer Inc
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Filing: 1974-05-29
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Granted: 1976-01-06
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Expires: 1994-05-29
Abstract
Abstract Novel 3-alkyl-9-aminoalkyl-1,2,3,4-tetrahydrocarbazoles having gastric anti-secretory activity are prepared. A typical embodiment is 3-tertiary-butyl-9-(2-pyrrolidino-ethyl)-1,2,3,4-tetrahydrocarbazole.
Inventors
- 👤 Peter E. Cross
- 👤 Roger P. Dickinson
- 👤 John E. G. Kemp
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 17:16
CPC Classifications
C; C07; C07D; C07D209/00; C07D209/56; C07D209/80; C07D209/82; C07D209/86
Claims Analysis
Total Claims: 9
Claim 1
Independent Claim
168 words
A compound of the formula: ##SPC7## or an N-oxide or a pharmaceutically-acceptable acid addition salt thereof wherein R is alkyl of from 3 to 5 carbon atoms, R 1 is hydrogen, halogen, lower alkyl, lower alkoxy or hydroxy; and Y is aminoalkyl of the formula --Alk--NR 2 R 3 in which R 2 and R 3 taken separately are each lower alkyl and R 2 and R 3 taken together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, perhydroazepino, morpholino, thiomorpholino or 1,1-dioxo-perhydro-1,4-thiazino group and `Alk` is a divalent alkyl group containing from 2 to 4 carbon atoms; or Y is an amino-cyclic group of the formula --C n H 2n --CH Z, in which n is 0 to 3 and Z is a divalent group which completes a pyrrolidine, piperidine or perhydroazepine ring, the nitrogen atom in said ring being separated from the nitrogen atom to which the aminocyclic group is attached by a chain of from 2 to 4 carbon atoms.
Claim 2
Dependent Claim
168 words
A compound of the formula: ##SPC7## or an N-oxide or a pharmaceutically-acceptable acid addition salt thereof wherein R is alkyl of from 3 to 5 carbon atoms, R 1 is hydrogen, halogen, lower alkyl, lower alkoxy or hydroxy; and Y is aminoalkyl of the formula --Alk--NR 2 R 3 in which R 2 and R 3 taken separately are each lower alkyl and R 2 and R 3 taken together with the nitrogen atom to which they are attached form a pyrrolidino, piperidino, perhydroazepino, morpholino, thiomorpholino or 1,1-dioxo-perhydro-1,4-thiazino group and `Alk` is a divalent alkyl group containing from 2 to 4 carbon atoms; or Y is an amino-cyclic group of the formula --C n H 2n --CH Z, in which n is 0 to 3 and Z is a divalent group which completes a pyrrolidine, piperidine or perhydroazepine ring, the nitrogen atom in said ring being separated from the nitrogen atom to which the aminocyclic group is attached by a chain of from 2 to 4 carbon atoms.
Claim 3
Dependent Claim
21 words
A compound as claimed in claim 1, in which R is a branched chain alkyl group containing a quaternary carbon atom.
Claim 4
Dependent Claim
15 words
A compound as claimed in claim 2, in which R is a tertiary butyl group.
Claim 5
Dependent Claim
15 words
A compound as claimed in claim 1, in which R 1 is hydrogen or halogen.
Claim 6
Dependent Claim
25 words
A compound as claimed in claim 1, in which Y is an aminoalkyl group --Alk--NR 2 R 3 in which `Alk` is ethylene or trimethylene.
Claim 7
Dependent Claim
23 words
A compound as claimed in claim 5, in which --NR 2 R 3 is a dimethylamino, diethylamino, pyrrolidino, piperidino, perhydroazepino or morpholino group.
Claim 8
Dependent Claim
11 words
3-Tertiary-butyl-9-(2-pyrrolidino-ethyl)-1,2,3,4-tetrahydrocarbazole, or an N-oxide or a pharmaceutically-acceptable acid addition salt thereof.
Claim 9
Dependent Claim
11 words
3-Tertiary-butyl-9-(2-pyrrolidino-ethyl)-1,2,3,4-tetrahydrocarbazole, or an N-oxide or a pharmaceutically-acceptable acid addition salt thereof.
References Cited (Backward Citations)
US2541211A
Cited
US3663567A
Cited
USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1979-01-05 | 1979-07-07 | 1980-01-06 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1983-01-05 | 1983-07-07 | 1984-01-06 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1987-01-05 | 1987-07-07 | 1988-01-06 | $7700.00 | Window Closed / Lapsed |