US3926188A
Expired / Lapsed
US
⏱️ 0.0 years remaining
Laminated drug dispenser
Assignee: Alza Corp
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Filing: 1974-11-14
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Granted: 1975-12-16
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Expires: 1994-11-14
Abstract
Abstract A three layer laminate drug dispenser comprising a core lamina of a crystalline drug of low water solubility dispersed homogeneously in a polymer matrix of permeability, P, to the drug, the lamina having a thickness, 2t, and a surface area, A, interposed between outer laminas made of a drug release rate controlling polymer of permeability, P'', to the drug, each outer lamina having a thickness, t'',and the combined, exposed surface area of the outer laminas being A'' wherein the expression and the expression k being a constant whose value is dependent upon the geometrical shape of the dispenser.
Inventors
- 👤 Richard W Baker
- 👤 Robert M Gale
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 00:14
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0087; A61K9/0092; A61K9/0002; A61K9/0004; A61K9/0012; A61K9/0048; A61K9/0051; A61M; A61M31/00; A61M31/002
Claims Analysis
Total Claims: 14
Claim 1
Independent Claim
95 words
An active agent dispenser comprising a laminate of: a. a core lamina of particles of a crystalline active agent of low water solubility dispersed in a solid material having a permeability, P, to the agent, the core lamina having a thickness 2t, and an exposed surface area, A, from which agent is released, and being partially covered by; b. at least one outer lamina made of an active agent release rate controlling polymer having a permeability, P'', to the agent, a thickness, t'', and an exposed surface area, A'', from which agent is released wherein
Claim 2
Dependent Claim
95 words
An active agent dispenser comprising a laminate of: a. a core lamina of particles of a crystalline active agent of low water solubility dispersed in a solid material having a permeability, P, to the agent, the core lamina having a thickness 2t, and an exposed surface area, A, from which agent is released, and being partially covered by; b. at least one outer lamina made of an active agent release rate controlling polymer having a permeability, P'', to the agent, a thickness, t'', and an exposed surface area, A'', from which agent is released wherein
Claim 3
Dependent Claim
11 words
The dispenser of claim 1 wherein the agent is a drug.
Claim 4
Dependent Claim
7 words
The drug dispenser of claim 2 wherein
Claim 5
Dependent Claim
13 words
The drug dispenser of claim 2 wherein P is substantially greater than P''.
Claim 6
Dependent Claim
28 words
The drug dispenser of claim 4 wherein P is substantially greater than P'' because of the porosity of the core lamina caused by the quantity of drug therein.
Claim 7
Dependent Claim
20 words
The drug dispenser of claim 2 wherein the drug initially comprises 30 to 75% by weight of the core lamina.
Claim 8
Dependent Claim
20 words
The drug dispenser of claim 2 wherein the solubility of the drug in water is less than 4% by weight.
Claim 9
Dependent Claim
30 words
The drug dispenser of claim 2 wherein the drug is chloramphenicol, physostigmine or hydrocortisone, and the dispenser is sized and shaped for insertion in the cul-de-sac of a human eye.
Claim 10
Dependent Claim
26 words
The dispenser of claim 1 wherein the dispenser is a three layer sandwich-type laminate, said core lamina being sandwiched between a pair of said outer lamina.
Claim 11
Dependent Claim
21 words
The dispenser of claim 9 wherein the laminate has the geometrical shape of a thin circular disc and k is 8.
Claim 12
Dependent Claim
21 words
The dispenser of claim 9 wherein the laminate has the geometrical shape of a thin elliptical disc and k is 4.
Claim 13
Dependent Claim
31 words
The dispenser of claim 1 wherein the dispenser is a concentric-type laminate, said outer lamina being outerly concentric to said core lamina and covering the axial surface of said core lamina.
Claim 14
Dependent Claim
20 words
The dispenser of claim 12 wherein the laminate is cylindrical in shape and k has a value of 1/8 .
References Cited (Backward Citations)
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USPTO Annuity & Maintenance Windows
| Annuity Stage | Window Opens | Payment Deadline | Surcharge Period Until | Estimated Fee | Status |
|---|---|---|---|---|---|
| 3.5 Years (Year 4) | 1978-12-15 | 1979-06-16 | 1979-12-16 | $2000.00 | Window Closed / Lapsed |
| 7.5 Years (Year 8) | 1982-12-15 | 1983-06-16 | 1983-12-16 | $3760.00 | Window Closed / Lapsed |
| 11.5 Years (Year 12) | 1986-12-15 | 1987-06-16 | 1987-12-16 | $7700.00 | Window Closed / Lapsed |