Compositions and method for binding bile acids in vivo including hypocholesteremics

Claim 1

THE METHOD OF LOWING CHOLESTEROL BLOOD LEVEL IN A HYPERCHOLESTEROLEMIC PATIENT WHICH COMPRISES ADMINISTERING ORALLY FROM 0.1 TO 1250 G. OF A NON-TOXIC POLYMER WHICH IS A WATER-SOLUBLE POLYMERIC AMINE SELECTED FROM THE GROUP CONSISTING OF, (A) POLYACRYLIC ACID ESTERIFIED Y SUFFICIENT OF A QUATERNARY AMMONIUM SUBSTITUTED ALCOHOL TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE QUATERNARY AMONIUM GROUPS, OF LESS THAN 500, (B) POLYACRYLIC ACID ESTERIFIED BY SUFFICIENT OF A A TERTIARY AMINE SUBSTITUTED ALCOHOL TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE TERTIARY AMINE GROUPS, OF LESS THAN 500, (C) POLYETHYLENEIMINE, (D) THE COPOLYMER OF 30 PARTS BY WEIGHT OF ACRYLAMIDE AND 70 PARTS BY WEIGHT VINYL BENZYL TRIMETHYL AMMONIUM CHLORIDE, (E) POLYSTYRENE SUBSTITUTED IN THE PHENYL GROUPS WITH SUFFICIENT NUMBER OF QUATERNARY AMMONIUM METHYL GROUPS TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE AMMONIUM GROUPS, OF LESS THAN 500, (F) POLYACRYAMIDE IN WHICH SUFFICIENT OF THE AMIDE SIDE CHAINS HAVE BEEN CONVERTED TO QUATERNARY AMMONIUM ALKYL ESTER GROUPS TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE AMMONIUM GROUPS OF LESS THAN 500, (G) POLYACRYLONITRILE IN WHICH SUFFICIENT OF THE NITRILE SIDE CHAIN GORUPS HAVE BEEN CONVERTED TO QUATENARY AMMONIUM ALKYL ESTER GROUPS TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE AMMONIUM GROUPS, OF LESS THAN 500, SAID POLYMER BEING FURTHER CHARACTERIZED BY, (1) A MOLECULAR WEIGHT OF AT LEAST 1500, (2) THE PROPERTY OF BINDING AT LEAST 80% OF AN EQUAL WEIGHT OF GLYOCHOLIC ACID IN VITRO INTO A FORM INCAPABLE OF DIALYSIS THROUGH A CELLOPHANE MEMBRANE, AND (3) A POLYMERIC SKELETON INERT TO DEGRADATION BY DIGESTIVE ENZYMES, AND AN ORALLY INGESTIBLE CARRIER, SAID CARRIER BEING A BALANCED SYNTHETIC DIET FOR HUMAN CONSUMPTOIN OF CONTROLLED CALORIC CONTENT.

Claim 2

THE METHOD OF LOWING CHOLESTEROL BLOOD LEVEL IN A HYPERCHOLESTEROLEMIC PATIENT WHICH COMPRISES ADMINISTERING ORALLY FROM 0.1 TO 1250 G. OF A NON-TOXIC POLYMER WHICH IS A WATER-SOLUBLE POLYMERIC AMINE SELECTED FROM THE GROUP CONSISTING OF, (A) POLYACRYLIC ACID ESTERIFIED Y SUFFICIENT OF A QUATERNARY AMMONIUM SUBSTITUTED ALCOHOL TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE QUATERNARY AMONIUM GROUPS, OF LESS THAN 500, (B) POLYACRYLIC ACID ESTERIFIED BY SUFFICIENT OF A A TERTIARY AMINE SUBSTITUTED ALCOHOL TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE TERTIARY AMINE GROUPS, OF LESS THAN 500, (C) POLYETHYLENEIMINE, (D) THE COPOLYMER OF 30 PARTS BY WEIGHT OF ACRYLAMIDE AND 70 PARTS BY WEIGHT VINYL BENZYL TRIMETHYL AMMONIUM CHLORIDE, (E) POLYSTYRENE SUBSTITUTED IN THE PHENYL GROUPS WITH SUFFICIENT NUMBER OF QUATERNARY AMMONIUM METHYL GROUPS TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE AMMONIUM GROUPS, OF LESS THAN 500, (F) POLYACRYAMIDE IN WHICH SUFFICIENT OF THE AMIDE SIDE CHAINS HAVE BEEN CONVERTED TO QUATERNARY AMMONIUM ALKYL ESTER GROUPS TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE AMMONIUM GROUPS OF LESS THAN 500, (G) POLYACRYLONITRILE IN WHICH SUFFICIENT OF THE NITRILE SIDE CHAIN GORUPS HAVE BEEN CONVERTED TO QUATENARY AMMONIUM ALKYL ESTER GROUPS TO GIVE AN EQUIVALENT WEIGHT, BASED ON THE AMMONIUM GROUPS, OF LESS THAN 500, SAID POLYMER BEING FURTHER CHARACTERIZED BY, (1) A MOLECULAR WEIGHT OF AT LEAST 1500, (2) THE PROPERTY OF BINDING AT LEAST 80% OF AN EQUAL WEIGHT OF GLYOCHOLIC ACID IN VITRO INTO A FORM INCAPABLE OF DIALYSIS THROUGH A CELLOPHANE MEMBRANE, AND (3) A POLYMERIC SKELETON INERT TO DEGRADATION BY DIGESTIVE ENZYMES, AND AN ORALLY INGESTIBLE CARRIER, SAID CARRIER BEING A BALANCED SYNTHETIC DIET FOR HUMAN CONSUMPTOIN OF CONTROLLED CALORIC CONTENT.