Pharmaceutical preparations and method and apparatus for making same

Claim 1

THE METHOD OF TREATING A VERTEBRATE TYPE ANIMAL WHICH COMPRISES ADMINISTERING ORALLY A PLURALITY OF DROPLET SIZE SOLID, SUBSTANTIALLY HOMOGENEOUS SPHEROIDAL BEADS COMPRISING A CONGEALABLE SOL AND A PHARMACOLOGICALLY ACTIVE INGREDIENT SUFFICIENT TO GIVE A PHARMACOLOGICAL RESPONSE UPON INGESTION AND ABSORPTION, SAID INGREDIENT BEING UNIFORMLY DISTRIBUTED THROUGHOUT SAID SOL, SAID DROPLET BEADS BEING MADE BY THE STEPS OF DIRECTING AN IMMISCIBLE LIQUID IN SUCH A MANNER AS TO FORM A CONTINUOUS STREAM, DIRECTING A CONGEALABLE SOL HAVING SAID PHARMACOLIGICALLY ACTIVE INGREDIENT DISTRIBUTED UNIFORMLY THERETHROUGH THROUGH A FINE ORIFICE OF A DIAMETER NOT GREATER THAN THE INTERNAL DIAMEETER OF A SIZE 18 HYPODERMIC NEEDLE UNDER PRESSURE SUFFICIENT TO FORM A FINE UNINTERRUPTED FILAMENT, DIRECTING THE UNINTERRUPTED FILAMENT INTO THE STREAM, MAINTAINING THE TEMPERATURE OF SAID STREAM OF IMMISCIBLE LIQUID BELOW THE CONGEALING TEMPERATURE OF SAID CONGEALABLE SOL, CONTROLLING THE VELOCITIES OF THE STREAM RELATIVE TO THE FILAMENT AS THEY MOVE ALONG IN THE PATH OF THE STREAM IN SUCH A MANNER AS TO CAUSE THE UNINTERRUPTED FILAMENT TO MOVE UNINTERRUPTEDLY IN THE DIRECTION OF MOVEMENT OF THE STREAM ALONG THE STREAM AT A VELOCITY SUFFICIENT TO PREVENT SUBSTANTIAL INCREASE IN GROSS SECTION OF THE UNITERRUPTED FILAMENT AND THEREAFTER TO CAUSE THE FILAMENT TO BREAK UP INTO ELONGATED SEGMENTS WHICH QUICKLY CONTRACT LENGTHWISE INTO SOLID, SUBSTANTIALLY HOMOGENEOUS SPHEROIDAL BEADS AND THUS PROVIDE SPACES BETWEEN THE INDIVIDUAL BEADS TO PREVENT COALESCING AS THE BEADS FLOW IN THE IMMISCIBLE STREAM AND THEREAFTER GEL.

Claim 2

THE METHOD OF TREATING A VERTEBRATE TYPE ANIMAL WHICH COMPRISES ADMINISTERING ORALLY A PLURALITY OF DROPLET SIZE SOLID, SUBSTANTIALLY HOMOGENEOUS SPHEROIDAL BEADS COMPRISING A CONGEALABLE SOL AND A PHARMACOLOGICALLY ACTIVE INGREDIENT SUFFICIENT TO GIVE A PHARMACOLOGICAL RESPONSE UPON INGESTION AND ABSORPTION, SAID INGREDIENT BEING UNIFORMLY DISTRIBUTED THROUGHOUT SAID SOL, SAID DROPLET BEADS BEING MADE BY THE STEPS OF DIRECTING AN IMMISCIBLE LIQUID IN SUCH A MANNER AS TO FORM A CONTINUOUS STREAM, DIRECTING A CONGEALABLE SOL HAVING SAID PHARMACOLIGICALLY ACTIVE INGREDIENT DISTRIBUTED UNIFORMLY THERETHROUGH THROUGH A FINE ORIFICE OF A DIAMETER NOT GREATER THAN THE INTERNAL DIAMEETER OF A SIZE 18 HYPODERMIC NEEDLE UNDER PRESSURE SUFFICIENT TO FORM A FINE UNINTERRUPTED FILAMENT, DIRECTING THE UNINTERRUPTED FILAMENT INTO THE STREAM, MAINTAINING THE TEMPERATURE OF SAID STREAM OF IMMISCIBLE LIQUID BELOW THE CONGEALING TEMPERATURE OF SAID CONGEALABLE SOL, CONTROLLING THE VELOCITIES OF THE STREAM RELATIVE TO THE FILAMENT AS THEY MOVE ALONG IN THE PATH OF THE STREAM IN SUCH A MANNER AS TO CAUSE THE UNINTERRUPTED FILAMENT TO MOVE UNINTERRUPTEDLY IN THE DIRECTION OF MOVEMENT OF THE STREAM ALONG THE STREAM AT A VELOCITY SUFFICIENT TO PREVENT SUBSTANTIAL INCREASE IN GROSS SECTION OF THE UNITERRUPTED FILAMENT AND THEREAFTER TO CAUSE THE FILAMENT TO BREAK UP INTO ELONGATED SEGMENTS WHICH QUICKLY CONTRACT LENGTHWISE INTO SOLID, SUBSTANTIALLY HOMOGENEOUS SPHEROIDAL BEADS AND THUS PROVIDE SPACES BETWEEN THE INDIVIDUAL BEADS TO PREVENT COALESCING AS THE BEADS FLOW IN THE IMMISCIBLE STREAM AND THEREAFTER GEL.