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US3022783A Expired / Lapsed US ⏱️ 0.0 years remaining

Method of preserving tissue such

Assignee: —
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Filing: —
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Granted: 1962-02-27
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Expires: 1979-02-27
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Abstract

No abstract record available.

Inventors

No inventors recorded.

Bibliographic Details

Application Number —
Jurisdiction US
Data Source google_patents
Last Synchronized 2026-10-23 14:18
CPC Classifications
A; A01; A01N; A01N1/00; A01N1/10; A01N1/12; A01N1/122; A01N1/125; A01N1/126; A61; A61B; A61B5/00; A61B5/06; A61K; A61K35/00; A61K35/12; A61K35/32; A61L; A61L27/00; A61L27/36; A61L27/3683; A61L27/3687

Claims Analysis

Total Claims: 2
Claim 1
Independent Claim 257 words
A METHOD OF REDUCING THE ANTIGENICITY OF DUMB ANIMAL TISSUE SO AS TO RENDER IT UNIVERSALLY COMPATIBLE WITH HUMAN TISSUE, SUCH TISSUE AND ENCOURAGING CELL GROWTH THEREOF DURING PRESERVATION, COMPRISING TESTING DUMB ANIMALS FOR DISEASE, REMOVING TISSUE FROM A TESTED HEALTHY DUMB ANIMAL BODY UNDER STERILE CONDITIONS, PLACING THE TISSUE IN A CONTAINER HAVING IN NORMAL SALINE THEREIN A SOLUBLE SODIUM SULFONAMIDE COMPOUND, AN ANTIBIOTIC AGENT, AND A BLOOD COMPONENT BATH FROM THE TYPE OF ANIMAL FROM WHICH THE TISSUE HAS BEEN REMOVED, MAINTAINING THE CONTAINER CONTENTS AT TEMPERATURES SUBSTANTIALLY BELOW NORMAL BODY TEMPERATURES AND ABOVE FREEZING, DEVELOPING OSTEOGENIC FACTOR CONDITIONED MUCO-PROTEIN AND MUCO-POLYSACCHARIDES OF TISSUE DURING PRESERVATION, INCREASING THE HYDROGEN ION CONCENTRATION OF THE OF BATH DURING PRESERVATION BY THE REACTION OF THE SOLUBLE SODIUM SULFONAMIDE COMPONENT OF THE BATH WITH THE TISSUE TO PRODUCE SODIUM SALT LINKED WITH TISSUE PROTEIN BONDED BY A DOUBLE SULPHUR BOND TO THE AMIDE RING WHEREBY THE PROTEIN IS MORE DENATURED AND LESS ANTIGENIC, CONVERTING PERIPHERAL FIBROBLASTS DURING PRESERVATION TO FIBROBLASTIC TISSUE AND ENCOURAGING THE GROWTH OF TISSUE CELLS, TESTING THE PRESERVED TISSUE AT INTERVALS TO OBSERVE FOR INDICATIONS OF ATROPHY AND NECROSIS, AND REPLENISHING WHEN NECESSARY THE BLOOD COMPONENTS WITH BLOOD COMPONENTS FROM THE TYPE OF ANIMAL FROM WHICH THE TISSUE UNDER PRESERVATION HAS BEEN OBTAINED, WHEREBY UPON HETEROGENEOUSLY GRAFTING THE TISSUE THUS PRESERVED ONTO A LIVE ANIMAL THE OSTEOGENIC FACTOR WILL STIMULATE TISSUE GRAFT GROWTH IN THE GRAFT BED AND THE DEPLETION OF ANTIGENS AND DENATURING RESULTS IN THE GRAFT TISSUE MORE READILY TAKING WITH THE GRAFT BED.
Claim 2
Independent Claim 257 words
A METHOD OF REDUCING THE ANTIGENICITY OF DUMB ANIMAL TISSUE SO AS TO RENDER IT UNIVERSALLY COMPATIBLE WITH HUMAN TISSUE, SUCH TISSUE AND ENCOURAGING CELL GROWTH THEREOF DURING PRESERVATION, COMPRISING TESTING DUMB ANIMALS FOR DISEASE, REMOVING TISSUE FROM A TESTED HEALTHY DUMB ANIMAL BODY UNDER STERILE CONDITIONS, PLACING THE TISSUE IN A CONTAINER HAVING IN NORMAL SALINE THEREIN A SOLUBLE SODIUM SULFONAMIDE COMPOUND, AN ANTIBIOTIC AGENT, AND A BLOOD COMPONENT BATH FROM THE TYPE OF ANIMAL FROM WHICH THE TISSUE HAS BEEN REMOVED, MAINTAINING THE CONTAINER CONTENTS AT TEMPERATURES SUBSTANTIALLY BELOW NORMAL BODY TEMPERATURES AND ABOVE FREEZING, DEVELOPING OSTEOGENIC FACTOR CONDITIONED MUCO-PROTEIN AND MUCO-POLYSACCHARIDES OF TISSUE DURING PRESERVATION, INCREASING THE HYDROGEN ION CONCENTRATION OF THE OF BATH DURING PRESERVATION BY THE REACTION OF THE SOLUBLE SODIUM SULFONAMIDE COMPONENT OF THE BATH WITH THE TISSUE TO PRODUCE SODIUM SALT LINKED WITH TISSUE PROTEIN BONDED BY A DOUBLE SULPHUR BOND TO THE AMIDE RING WHEREBY THE PROTEIN IS MORE DENATURED AND LESS ANTIGENIC, CONVERTING PERIPHERAL FIBROBLASTS DURING PRESERVATION TO FIBROBLASTIC TISSUE AND ENCOURAGING THE GROWTH OF TISSUE CELLS, TESTING THE PRESERVED TISSUE AT INTERVALS TO OBSERVE FOR INDICATIONS OF ATROPHY AND NECROSIS, AND REPLENISHING WHEN NECESSARY THE BLOOD COMPONENTS WITH BLOOD COMPONENTS FROM THE TYPE OF ANIMAL FROM WHICH THE TISSUE UNDER PRESERVATION HAS BEEN OBTAINED, WHEREBY UPON HETEROGENEOUSLY GRAFTING THE TISSUE THUS PRESERVED ONTO A LIVE ANIMAL THE OSTEOGENIC FACTOR WILL STIMULATE TISSUE GRAFT GROWTH IN THE GRAFT BED AND THE DEPLETION OF ANTIGENS AND DENATURING RESULTS IN THE GRAFT TISSUE MORE READILY TAKING WITH THE GRAFT BED.

References Cited (Backward Citations)

US2485791A Cited
US2621145A Cited
US2658021A Cited

USPTO Annuity & Maintenance Windows

Annuity Stage Window Opens Payment Deadline Surcharge Period Until Estimated Fee Status
3.5 Years (Year 4) 1965-02-26 1965-08-28 1966-02-27 $2000.00 Window Closed / Lapsed
7.5 Years (Year 8) 1969-02-26 1969-08-28 1970-02-27 $3760.00 Window Closed / Lapsed
11.5 Years (Year 12) 1973-02-26 1973-08-28 1974-02-27 $7700.00 Window Closed / Lapsed

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