US20050124849A1
Expired / Lapsed
US
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Partial aortic occlusion devices and methods for cerebral perfusion augmentation
Assignee: Zoll Circulation Inc
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Filing: 2005-01-24
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Granted: —
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Expires: 2025-01-24
Abstract
Abstract Methods are provided for partial aortic obstruction for cerebral perfusion augmentation in patients suffering from global or focal cerebral ischemia. Alternatively, the methods can be used to partially obstruct aortic blood flow to condition the spinal cord to secrete neuroprotective agents prior to abdominal aortic aneurysm repair. Partial obstruction of a vessel can be accomplished by a device comprising an elongate catheter and a distally mounted expandable member. The expandable member may comprise one or two balloons. Other medical devices, such as an angioplasty, stent, or atherectomy catheter, can be inserted distal the expandable member to provide therapeutic intervention.
Inventors
- 👤 Denise Barbut
- 👤 Peter Keith
- 👤 Steven Berhow
- 👤 Jon St. Germain
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 01:50
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/12; A61B17/12022; A61B17/12027; A61B17/1204; A61B17/12045; A61B17/12036; A61B17/12099; A61B17/12109; A61B17/12131; A61B17/12136; A61B17/1214; A61B17/12145; A61B17/12181; A61B17/1219; A61B5/00; A61B5/02; A61B5/021; A61B5/0215; A61B5/40; A61B5/4076; A61B6/00; A61B6/48; A61B6/481; A61F; A61F7/00; A61F7/12; A61M; A61M25/00; A61M25/0021; A61M25/0023; A61M25/0026; A61M25/003; A61M25/0067; A61M25/0068; A61M25/008; A61M25/0082; A61M25/01; A61M25/0105; A61M25/0133; A61M25/0147; A61M25/10; A61M25/1011; A61B17/22; A61B2017/22051; A61B2017/22054; A61B90/00; A61B90/39; A61B2090/3966; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2002/068; A61F2007/126; A61M2025/0001; A61M2025/0002; A61M2025/0034; A61M2025/0073; A61M2025/0081; A61M2025/1043; A61M2025/1052; A61M2210/00; A61M2210/12; A61M2210/127; A61M2230/00; A61M2230/005; A61M2230/30; A61M25/0032; A61M25/0069; A61M25/0074; A61M25/06; A61M25/0662
Claims Analysis
Total Claims: 20
Claim 1
Independent Claim
95 words
1 . A method for increasing cerebral blood flow, comprising the steps of: inserting a catheter into the descending aorta, the catheter having a proximal end, a distal end, a first expandable member mounted on the distal end, and a second expandable member mounted on the distal end proximal the first expandable member; locating the first expandable member upstream from the takeoff of the renal arteries; locating the second expandable member downstream from the takeoff of the renal arteries; and expanding the first expandable member to at least partially occlude blood flow in the aorta.
Claim 2
Dependent Claim
95 words
1 . A method for increasing cerebral blood flow, comprising the steps of: inserting a catheter into the descending aorta, the catheter having a proximal end, a distal end, a first expandable member mounted on the distal end, and a second expandable member mounted on the distal end proximal the first expandable member; locating the first expandable member upstream from the takeoff of the renal arteries; locating the second expandable member downstream from the takeoff of the renal arteries; and expanding the first expandable member to at least partially occlude blood flow in the aorta.
Claim 3
Dependent Claim
24 words
2 . The method of claim 1 , wherein the first expandable member is located upstream from the takeoff of the superior mesenteric artery.
Claim 4
Dependent Claim
42 words
3 . The method of claim 1 , wherein the catheter includes pressure measuring capabilities disposed between the first and second expandable members, and wherein the method further comprises the step of measuring blood pressure between the first and second expandable members.
Claim 5
Dependent Claim
35 words
4 . The method of claim 1 , wherein the catheter further comprises a stiffening element, and wherein the method further comprises the step of inserting the stiffening element into a lumen of the catheter.
Claim 6
Dependent Claim
24 words
5 . The method of claim 1 , further comprising the step of expanding the second constrictor to partially occlude blood flow in aorta.
Claim 7
Dependent Claim
21 words
6 . The method of claim 5 , further comprising the step of partially reducing the expansion of the first constrictor.
Claim 8
Dependent Claim
17 words
7 . The method of claim 1 , further comprising the step of measuring cerebral blood flow.
Claim 9
Dependent Claim
127 words
8 . A medical device for partial aortic occlusion for cerebral perfusion augmentation, comprising: an elongate member having proximal and distal ends and proximal and distal regions, the distal region having a greater flexibility than the proximal region; a first expandable member mounted at the distal end of the elongate member; and a second expandable member mounted at the distal end of the elongate member proximal the first expandable member; wherein, during use, the flexible distal region allows the elongate member to conform to the descending aorta while the first and second expandable members are positioned in the descending aorta downstream of the left subclavian artery and are at least partially expanded to increase cerebral perfusion, and the proximal region provides stability to prevent migration during use.
Claim 10
Dependent Claim
127 words
8 . A medical device for partial aortic occlusion for cerebral perfusion augmentation, comprising: an elongate member having proximal and distal ends and proximal and distal regions, the distal region having a greater flexibility than the proximal region; a first expandable member mounted at the distal end of the elongate member; and a second expandable member mounted at the distal end of the elongate member proximal the first expandable member; wherein, during use, the flexible distal region allows the elongate member to conform to the descending aorta while the first and second expandable members are positioned in the descending aorta downstream of the left subclavian artery and are at least partially expanded to increase cerebral perfusion, and the proximal region provides stability to prevent migration during use.
Claim 11
Dependent Claim
31 words
9 . The device of claim 8 , further comprising a first centering mechanism disposed about the first expandable member for centering the first expandable member within the aorta when deployed.
Claim 12
Dependent Claim
31 words
10 . The device of claim 8 , further comprising a second centering mechanism disposed about the second expandable member for centering the second expandable member within the aorta when deployed.
Claim 13
Dependent Claim
17 words
11 . The device of claim 8 , wherein the first and second expandable members are balloons.
Claim 14
Dependent Claim
30 words
12 . The device of claim 8 , wherein the first and second expandable members are cylindrical expandable balloons, each having an outer surface, a lumen, and an enclosed chamber.
Claim 15
Dependent Claim
22 words
13 . The device of claim 8 , wherein the pressure measuring device is disposed between the first and second expandable members.
Claim 16
Dependent Claim
23 words
14 . The device of claim 8 , further comprising a stiffening element that is insertable into a lumen of the elongate member.
Claim 17
Dependent Claim
19 words
15 . The medical device of claim 8 , wherein the elongate member comprises three regions of different flexibility.
Claim 18
Dependent Claim
28 words
16 . The medical device of claim 8 , further comprising a pressure monitoring device operable to measure blood pressure in the aorta upstream the second expandable member.
Claim 19
Dependent Claim
28 words
17 . The device of claim 16 , wherein the pressure measuring device is a pressure tube carried by the catheter and proximally connected to a pressure monitor.
Claim 20
Dependent Claim
24 words
18 . The device of claim 16 , wherein the pressure measuring device is a manometer mounted at the distal end of the catheter.
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