US20030100920A1
Expired / Lapsed
US
⏱️ 0.0 years remaining
Devices and methods for interconnecting conduits and closing openings in tissue
Assignee: Bioconnect Systems Inc
•
Filing: 2002-09-04
•
Granted: —
•
Expires: 2022-09-04
Abstract
Abstract The subject invention provides devices and methods for closing and sealing an opening in a conduit. The subject devices consist of an implantable flexible member adapted to conform to and seal with an inner surface of a conduit and further adapted to utilize the internal conduit pressure exerted thereon to form a substantially fluid-tight seal with the inner surface of the conduit whereby substances are prevented from leaking from the opening under normal physiological conditions. In the subject methods, a subject device is provided and positioned inside a conduit, operatively aligned over an opening to be sealed. The device is conformed to and sealed with an inner surface of the conduit and a substantially fluid-tight seal is formed between the device and the inner surface of the conduit utilizing the internal conduit pressure whereby substances within the conduit are prevented from leaking from the opening under normal physiological conditions.
Inventors
- 👤 Jodi Akin
- 👤 Stephen Ramee
Bibliographic Details
Application Number
—
Jurisdiction
US
Data Source
google_patents
Last Synchronized
2026-10-23 04:53
CPC Classifications
A; A61; A61B; A61B17/00; A61B17/11; A61F; A61F2/00; A61F2/02; A61F2/04; A61F2/06; A61F2/064; A61B2017/00831; A61B2017/00867; A61B2017/1107; A61B2017/1135; A61B2017/1139
Claims Analysis
Total Claims: 87
Claim 1
Independent Claim
90 words
1 . A device for closing an opening in a tissue structure of a subject, said device consisting of: an implantable flexible segment adapted to conform to and seal with an inner surface of said tissue structure over said opening and further adapted to utilize the internal tissue structure pressure exerted thereon to form a substantially fluid-tight seal with said inner surface over said opening of said tissue structure whereby substances within said tissue structure are prevented from leaking from said opening in said tissue structure under normal physiological conditions.
Claim 2
Dependent Claim
90 words
1 . A device for closing an opening in a tissue structure of a subject, said device consisting of: an implantable flexible segment adapted to conform to and seal with an inner surface of said tissue structure over said opening and further adapted to utilize the internal tissue structure pressure exerted thereon to form a substantially fluid-tight seal with said inner surface over said opening of said tissue structure whereby substances within said tissue structure are prevented from leaking from said opening in said tissue structure under normal physiological conditions.
Claim 3
Dependent Claim
20 words
2 . The device according to claim 1 , wherein said flexible segment is further adapted to be permanently implanted.
Claim 4
Dependent Claim
21 words
3 . The device according to claim 1 , wherein said flexible segment is further adapted to be biodegradable or bioresorbable.
Claim 5
Dependent Claim
26 words
4 . The device according to claim 1 , wherein said flexible segment forms said substantially fluid-tight seal without compressing, tensioning or puncturing said conduit wall.
Claim 6
Dependent Claim
20 words
5 . The device according to claim 1 , wherein said tissue structure is a septal wall of a heart.
Claim 7
Dependent Claim
17 words
6 . The device according to claim 1 , wherein said tissue structure is a blood vessel.
Claim 8
Dependent Claim
18 words
7 . The device according to claim 1 , wherein said device comprises one or more thrombogenic substances.
Claim 9
Dependent Claim
15 words
8 . The device according to claim 1 , wherein said device comprises an aperture.
Claim 10
Dependent Claim
20 words
9 . The device according to claim 8 , wherein one or more thrombogenic substances are associated with said aperture.
Claim 11
Dependent Claim
16 words
10 . The device according to claim 8 , aperture has a cover over said aperure.
Claim 12
Dependent Claim
16 words
11 . The device according to claim 10 , wherein said cover is a thin membrane.
Claim 13
Dependent Claim
23 words
12 . The device according to claim 11 , wherein said thin membrane is penetrable by a guide wire or other delivery device.
Claim 14
Dependent Claim
47 words
13 . The device according to claim 8 , wherein said aperture is self-closing and self-sealing such that an opening created by said guide wire or other delivery device is automatically closed and sealed following removal of said guide wire or other delivery device from said aperture.
Claim 15
Dependent Claim
18 words
14 . The device according to claim 8 , wherein a metal mesh is associated with said aperture.
Claim 16
Dependent Claim
22 words
15 . The device according to claim 8 , wherein said device further comprises a stoma and said stoma provides said aperture.
Claim 17
Dependent Claim
16 words
16 . The device according to claim 15 , wherein said stoma comprises a transition portion.
Claim 18
Dependent Claim
34 words
17 . The device according to claim 16 , wherein said transition portion is fabricated from at least one of nitinol or other shaped memory material, stainless steel, a polymer or a combination thereof.
Claim 19
Dependent Claim
20 words
18 . The device according to claim 17 , wherein said transition portion comprises one or more radially extending fingers.
Claim 20
Dependent Claim
33 words
19 . The device according to claim 8 , further comprises a valve associated with said aperture, wherein said valve prevents substances from within said tissue structure from flowing out of said aperture.
Claim 21
Dependent Claim
25 words
20 . The device according to claim 8 , wherein said device is configured to be delivered over a guide wire insterted through said aperture.
Claim 22
Dependent Claim
16 words
21 . The device according to claim 1 , wherein said device is biodegradable or bioresobable.
Claim 23
Dependent Claim
23 words
22 . The device according to claim 1 , wherein said device is coated with at least one substance beneficial to said subject.
Claim 24
Dependent Claim
23 words
23 . The device according to claim 1 , wherein said device is embedded with at least one substance beneficial to said subject.
Claim 25
Dependent Claim
19 words
24 . The device according to claim 1 , wherein at least one surface of said device is modified.
Claim 26
Dependent Claim
98 words
25 . A device for closing an opening in a tissue structure of a subject wherein the device is implantable to a site within said tissue structure of a subject through said opening, said device consisting of: a segment having a configuration and comprised of a compliant material whereby said segment is constrictable to a size sufficient to fit through said opening and is expandable to be securely and permanently self-retained within said tissue structure upon implantation whereby substances within said tissue structure are prevented from leaking from said opening in said tissue structure under normal physiological conditions.
Claim 27
Dependent Claim
98 words
25 . A device for closing an opening in a tissue structure of a subject wherein the device is implantable to a site within said tissue structure of a subject through said opening, said device consisting of: a segment having a configuration and comprised of a compliant material whereby said segment is constrictable to a size sufficient to fit through said opening and is expandable to be securely and permanently self-retained within said tissue structure upon implantation whereby substances within said tissue structure are prevented from leaking from said opening in said tissue structure under normal physiological conditions.
Claim 28
Dependent Claim
44 words
26 . The device according to claim 25 , wherein said segment readily conforms to and seals with an inner surface of said conduit upon deployment within said tissue structure to form a substantially fluid-tight seal with an inner surface of said tissue structure.
Claim 29
Dependent Claim
47 words
27 . The device according to claim 25 , wherein said segment comprises a tissue-contacting surface and a non tissue-facing surface, wherein, upon implantation of said compliant material, said tissue-contacting surface is adapted to readily conform to and seal with the inner surface of said tissue structure.
Claim 30
Dependent Claim
42 words
28 . The device according to claim 27 , wherein said non tissue-facing surface is adapted to utilize the internal conduit pressure exerted thereon to form a substantially fluid-tight seal between the tissue-contacting surface and said inner surface of said tissue structure.
Claim 31
Dependent Claim
16 words
29 . The device according to claim 25 , wherein said segment comprises a thin membrane.
Claim 32
Dependent Claim
21 words
30 . The device according to claim 25 , wherein said segment has a generally planar configuration in an original state.
Claim 33
Dependent Claim
21 words
31 . The device according to claim 25 , wherein said segment has a generally curved configuration in an original state.
Claim 34
Dependent Claim
24 words
32 . The device according to claim 25 , wherein said segment has at least a partially cylindrical configuration when in an original state.
Claim 35
Dependent Claim
21 words
32 . The device according to claim 25 , wherein said segment has a cylindrical configuration when in an original state.
Claim 36
Dependent Claim
16 words
33 . The device according to claim 25 , wherein said segment has a rectangular shape.
Claim 37
Dependent Claim
20 words
34 . The according to claim 25 , wherein said segment has a circular shape when in an original state.
Claim 38
Dependent Claim
20 words
35 . The according to claim 25 , wherein said segment has an elliptical shape when in an original state.
Claim 39
Dependent Claim
19 words
36 . The according to claim 25 , wherein said segment has petalled shape when in an original state.
Claim 40
Dependent Claim
21 words
37 . The device according to claim 25 , wherein said segment has a cylindrical configuration when implanted across said opening.
Claim 41
Dependent Claim
24 words
38 . The device according to claim 25 , wherein the surface area of said segment is at least about 40 mm 2 .
Claim 42
Dependent Claim
27 words
39 . The device according to claim 25 , wherein the thickness of said segment is in the range from about 100 microns to about 500 microns.
Claim 43
Dependent Claim
15 words
40 . The device according to claim 25 , wherein said segment comprises an elastomer.
Claim 44
Dependent Claim
16 words
41 . The device according to claim 25 , wherein said segment comprises a biocompatible material.
Claim 45
Dependent Claim
18 words
42 . The device according to claim 25 , wherein said segment comprises a biodegradable or bioresorbable material.
Claim 46
Dependent Claim
20 words
43 . The device according to claim 25 , wherein at least a portion of said segment comprises a metal.
Claim 47
Dependent Claim
19 words
44 . The device according to claim 43 , wherein said metal comprises stainless steel, vitalium, titanium or nitinol.
Claim 48
Dependent Claim
20 words
45 . The device according to claim 43 , wherein said metal is in the form of a wire mesh.
Claim 49
Dependent Claim
16 words
46 . The device according to claim 25 , wherein said segment comprises PTFE or Dacron.
Claim 50
Dependent Claim
16 words
47 . The device according to claim 25 , wherein said segment comprises a polymer material.
Claim 51
Dependent Claim
15 words
48 . The device according to claim 47 , wherein said polymer is an elastomer.
Claim 52
Dependent Claim
16 words
49 . The device according to claim 48 , wherein said elastomer comprises polysiloxane or polyurethane.
Claim 53
Dependent Claim
25 words
50 . The device according to claim 48 , wherein said elastomer has a durometer ranging from about 80 Shore A to 55 Shore D.
Claim 54
Dependent Claim
16 words
51 . The device according to claim 25 , wherein said segment comprises a bioprosthetic material.
Claim 55
Dependent Claim
21 words
52 . The device according to claim 51 , wherein said bioprosthetic material is fabricated from autologous, allogenic or xenogenic tissue.
Claim 56
Dependent Claim
25 words
53 . The device according to claim 25 , wherein said device is coated with at least one substance that is beneficial to said subject.
Claim 57
Dependent Claim
25 words
54 . The device according to claim 25 , wherein said device is embedded with at least one substance that is beneficial to said subject.
Claim 58
Dependent Claim
15 words
55 . The device according to claim 25 , wherein said device is surface modified.
Claim 59
Dependent Claim
18 words
56 . The device according to claim 25 , wherein said device comprises one or more thrombogenic substances.
Claim 60
Dependent Claim
15 words
57 . The device according to claim 25 , wherein said device comprises an aperture.
Claim 61
Dependent Claim
20 words
58 . The device according to claim 57 , wherein one or more thrombogenic substances are associated with said aperture.
Claim 62
Dependent Claim
16 words
59 . The device according to claim 57 , aperture has a cover over said aperure.
Claim 63
Dependent Claim
16 words
60 . The device according to claim 59 , wherein said cover is a thin membrane.
Claim 64
Dependent Claim
23 words
61 . The device according to claim 60 , wherein said thin membrane is penetrable by a guide wire or other delivery device.
Claim 65
Dependent Claim
47 words
62 . The device according to claim 57 , wherein said aperture is self-closing and self-sealing such that an opening created by said guide wire or other delivery device is automatically closed and sealed following removal of said guide wire or other delivery device from said aperture.
Claim 66
Dependent Claim
18 words
63 . The device according to claim 57 , wherein a metal mesh is associated with said aperture.
Claim 67
Dependent Claim
22 words
64 . The device according to claim 57 , wherein said device further comprises a stoma and said stoma provides said aperture.
Claim 68
Dependent Claim
16 words
65 . The device according to claim 64 , wherein said stoma comprises a transition portion.
Claim 69
Dependent Claim
34 words
66 . The device according to claim 65 , wherein said transition portion is fabricated from at least one of nitinol or other shaped memory material, stainless steel, a polymer or a combination thereof.
Claim 70
Dependent Claim
20 words
67 . The device according to claim 65 , wherein said transition portion comprises one or more radially extending fingers.
Claim 71
Dependent Claim
33 words
68 . The device according to claim 57 , further comprises a valve associated with said aperture, wherein said valve prevents substances from within said tissue structure from flowing out of said aperture.
Claim 72
Dependent Claim
25 words
69 . The device according to claim 57 , wherein said device is configured to be delivered over a guide wire insterted through said aperture.
Claim 73
Dependent Claim
121 words
70 . A method for closing an opening in a tissue structure of a subject, said method comprising: providing a device according to claim 1; positioning said device inside a tissue structure, whereby said device is operatively aligned with an opening in said tissue structure to be closed; conforming said device to and sealing said device against an inner surface of said tissue structure, wherein said opening is closed by said device; and permanently forming a substantially fluid-tight seal between said device and said inner surface of said tissue structure utilizing the internal tissue structure pressure exerted upon said device, whereby substances within said tissue structure are prevented from leaking from said opening in said tissue structure under normal physiological conditions.
Claim 74
Dependent Claim
16 words
71 . The method according to claim 70 , wherein said device is biodegraded or reabsorbed.
Claim 75
Dependent Claim
20 words
72 . The method according to claim 70 , further comprising forming a natural and permanent closure at said opening.
Claim 76
Dependent Claim
33 words
73 . The method according to claim 70 , wherein said step of positioning includes inserting a guide wire through said opening and delivering said device over said guide wire to said opening.
Claim 77
Dependent Claim
17 words
74 . The method according to claim 70 , wherein said tissue structure is a blood vessel.
Claim 78
Dependent Claim
20 words
75 . The method according to claim 70 , wherein said tissue structure is a septal wall of a heart.
Claim 79
Dependent Claim
142 words
76 . A method for forming a connection in situ between two conduits substantially adjacent to each other, said method comprising: forming a first opening in a wall of a first conduit; forming a second opening in said wall of said first conduit; penetrating through the tissue between said first conduit and a second conduit; forming an opening in said second conduit; inserting an anastomotic connector device through said first opening of said first conduit; inserting a portion of said device through said second opening of said first conduit; inserting said portion through said first opening of said second conduit; and deploying said device within said conduits such that said device provides a fluid connection between said conduits, wherein said device conforms to and seals with the inner surfaces of said first and second conduits utilizing the internal conduit pressures exerted thereon.
Claim 80
Dependent Claim
142 words
76 . A method for forming a connection in situ between two conduits substantially adjacent to each other, said method comprising: forming a first opening in a wall of a first conduit; forming a second opening in said wall of said first conduit; penetrating through the tissue between said first conduit and a second conduit; forming an opening in said second conduit; inserting an anastomotic connector device through said first opening of said first conduit; inserting a portion of said device through said second opening of said first conduit; inserting said portion through said first opening of said second conduit; and deploying said device within said conduits such that said device provides a fluid connection between said conduits, wherein said device conforms to and seals with the inner surfaces of said first and second conduits utilizing the internal conduit pressures exerted thereon.
Claim 81
Dependent Claim
23 words
77 . The method according to claim 76 , wherein one of said conduits is a artery and the other is a vein.
Claim 82
Dependent Claim
28 words
78 . The method according to claim 76 , further comprising closing and sealing said first opening of said first conduit with the device of claim 1 .
Claim 83
Dependent Claim
71 words
79 . A method of patching and sealing an irregularity on an inner surface of a conduit, said method comprising: positioning a patch comprising a flexible segment over said irregularity on said inner surface of said conduit; and by utilizing the internal conduit pressure, conforming said flexible segment to and sealing said flexible segment with said inner surface of said conduit, whereby said irregularity is patched and sealed by said patch.
Claim 84
Dependent Claim
71 words
79 . A method of patching and sealing an irregularity on an inner surface of a conduit, said method comprising: positioning a patch comprising a flexible segment over said irregularity on said inner surface of said conduit; and by utilizing the internal conduit pressure, conforming said flexible segment to and sealing said flexible segment with said inner surface of said conduit, whereby said irregularity is patched and sealed by said patch.
Claim 85
Dependent Claim
58 words
80 . A kit for closing an opening in a conduit of a subject, said kit comprising: at least one device according to claim 1; and instructions for using said at least one device for closing an opening in a tissue structure of a subject or for patching and sealing an irregularity on a surface of a conduit.
Claim 86
Dependent Claim
19 words
81 . The kit according to claim 80 , further comprising means for delivering said at least one device.
Claim 87
Dependent Claim
35 words
82 . The kit according to claim 80 , further comprising an element for sizing at least one of: an opening to be closed, an irregularity to be patched and sealed and said tissue structure.
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