Patent EP0953320A2 successfully refreshed from Google Patents.
EP0953320A2
Expired / Lapsed
EP
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Medical device
Assignee: Medtronic Inc
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Filing: 1999-04-30
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Granted: —
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Expires: 2019-04-30
Abstract
Abstract The invention relates to a medical device useful for the localized delivery of a therapeutic agent having at least one blood-contacting surface comprising a porous material having dispersed therein an elutable therapeutic agent. Preferred devices include a structure including a porous polymeric material and an elutable therapeutic agent in the form of a solid, gel, or neat liquid, which is dispersed in at least a portion of the porous polymeric material. Methods for making a medical device having a blood-contacting surface are also provided. One method includes the use of a concentrating agent whereby to localise the therapeutic agent within the porous material. Another method involves multiple immersion steps without the use of a concentrating agent.
Inventors
- 👤 Ronald J. Tuch
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 14:10
CPC Classifications
A; A61; A61F; A61F2/00; A61F2/82; A61F2/86; A61F2/88; A61L; A61L29/00; A61L29/04; A61L29/041; A61L29/044; A61L29/06; A61L29/14; A61L29/145; A61L29/146; A61L29/16; A61L31/00; A61L31/04; A61L31/042; A61L31/043; A61L31/048; A61L31/06; A61L31/08; A61L31/10; A61L31/14; A61L31/145; A61L31/146; A61L31/16; A61F2/95; A61F2/958; A61F2210/00; A61F2210/0004; A61F2240/00; A61F2240/001; A61F2250/00; A61F2250/0058; A61F2250/0067; A61L2300/00; A61L2300/20; A61L2300/23; A61L2300/236; A61L2300/40; A61L2300/42; A61L2300/432
Claims Analysis
Total Claims: 24
Claim 1
Independent Claim
20 words
A medical device having at least one blood-contacting
surface comprising a porous material having dispersed
therein an elutable therapeutic agent.
Claim 2
Dependent Claim
47 words
A medical device as claimed in claim 1 having at
least one blood-contacting surface comprising: a porous polymeric material; and an elutable therapeutic agent in the form of a solid,
gel, or neat liquid, which is dispersed in at least a
portion of said porous polymeric material.
Claim 3
Dependent Claim
18 words
A medical device as claimed in claim 1 or claim 2
wherein said porous material comprises a film.
Claim 4
Dependent Claim
22 words
A medical device as claimed in claim 1 or claim 2
wherein said porous material comprises an integral portion
of the device.
Claim 5
Dependent Claim
43 words
A medical device as claimed in any one of claims 1 to
4 wherein said porous material is a natural hydrogel, a
synthetic hydrogel, silicone, polyurethane, polysulfone,
cellulose, polyethylene, polypropylene, polyamide,
polyester, polytetrafluoroethylene, or a combination of
two or more of these materials.
Claim 6
Dependent Claim
22 words
A medical device as claimed in any one of claims 1 to
5 wherein said porous material comprises a non-swellable
biostable polymer.
Claim 7
Dependent Claim
17 words
A medical device as claimed in any preceding claim
wherein said therapeutic agent comprises an antithrombotic
material.
Claim 8
Dependent Claim
19 words
A medical device as claimed in claim 7 wherein the
antithrombotic material is heparin, a heparin derivative
or analog.
Claim 9
Dependent Claim
22 words
A medical device as claimed in any of one of claims 1
to 6 wherein said therapeutic agent is a peptidic drug.
Claim 10
Dependent Claim
16 words
A medical device as claimed in any preceding claim
having a generally cylindrical or sheet-like shape.
Claim 11
Dependent Claim
18 words
A medical device as claimed in any preceding claim
comprising a catheter, a stent, or a guide wire.
Claim 12
Dependent Claim
12 words
A medical device as claimed in claim 11 comprising an
intralumenal stent.
Claim 13
Dependent Claim
50 words
An intralumenal stent comprising: a generally cylindrical stent body; and an adherent layer on the stent body comprising a
porous polymeric material and an elutable therapeutic
agent in the form of a solid, gel, or neat liquid, which
is dispersed in at least a portion of the porous polymeric
material.
Claim 14
Independent Claim
82 words
A method for making a medical device, said method
comprising the steps of: (a) providing a structure comprising a porous
material; (b) contacting said structure with a concentrating
agent whereby to disperse the concentrating agent
throughout at least a portion of the porous material; (c) contacting said structure comprising a porous
material and the concentrating agent with a solution of a
therapeutic agent; and (d) removing the therapeutic agent from solution
within the porous material at the locations of the
concentrating agent.
Claim 15
Dependent Claim
33 words
A method as claimed in claim 14 wherein said
concentrating agent is selected from the group of a
binding agent, a sequestering agent, a nucleating agent, a
seed crystal, or a combination thereof.
Claim 16
Dependent Claim
34 words
A method as claimed in claim 14 or claim 15 wherein
step (d) is effected by reducing the temperature, changing
the pH or changing the ionic strength of the solution of
the therapeutic agent.
Claim 17
Independent Claim
77 words
A method for making a medical device, said method
comprising the steps of: (a) providing a structure comprising a porous
material; (b) immersing said structure in a saturated solution
of a therapeutic agent for a sufficient period of time to
allow the solution to fill the porous material; (c) removing the structure from the solution; (d) drying the structure; and (e) repeating steps (b) through (d) whereby to
provide a therapeutic agent dispersed within the porous
material.
Claim 18
Dependent Claim
28 words
A method as claimed in claim 17 further comprising a
step of removing air bubbles from the porous material
while immersed in the solution of the therapeutic agent.
Claim 19
Dependent Claim
34 words
A method as claimed in claim 18 wherein the step of
removing air bubbles from the porous material is effected
by applying ultrasonics, reduced pressure, elevated
pressure, or a combination thereof, to the solution.
Claim 20
Independent Claim
26 words
A method as claimed in any one of claims 14 to 19
further comprising the step of applying an overlayer of a
polymer to said structure.
Claim 21
Independent Claim
42 words
A method as claimed in any one of claims 14 to 20
wherein said porous material is a natural hydrogel, a
synthetic hydrogel, silicone, polyurethane, polysulfone,
cellulose, polyethylene, polypropylene, polyamide,
polyester, polytetrafluoroethylene, or a combination of
two or more of these materials.
Claim 22
Independent Claim
20 words
A method as claimed in any one of claims 14 to 21
wherein said therapeutic agent is an antithrombotic
material.
Claim 23
Dependent Claim
17 words
A medical device obtainable by a process as claimed
in any one of claims 14 to 22.
Claim 24
Dependent Claim
18 words
A substrate having at least one blood-contacting
surface as defined in any one of claims 1 to 9.
References Cited (Backward Citations)
No citation records indexed.
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