Patent EP0466300A2 successfully refreshed from Google Patents.
EP0466300A2
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EP
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Biocompatible viscoelastic gel slurries, their preparation and use
Assignee: Genzyme Corp
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Filing: 1991-04-22
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Granted: —
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Expires: 2011-04-22
Abstract
Abstract Biocompatible viscoelastic gel slurries formed from a polymeric gel, preferably a hyaluronan or a derivative thereof such as hylan swollen in an aqueous medium and a fluid phase which is an aqueous solution of a polymer which may also but not necessarily be a hyaluronan or derivative thereof. Also disclosed are methods of making such slurries, controlling their rheological properties and the uses thereof.
Inventors
- 👤 Edward Leshchiner
- 👤 Nancy E. Larsen
- 👤 Endre A. Balazs
- 👤 Adelya Leshchiner
Bibliographic Details
Application Number
—
Jurisdiction
EP
Data Source
google_patents
Last Synchronized
2026-10-23 04:59
CPC Classifications
A; A61; A61K; A61K9/00; A61K9/0012; A61K9/0019; A61K47/00; A61K47/30; A61K47/32; A61K47/34; A61K47/36; A61K47/38; A61L; A61L27/00; A61L27/14; A61L27/20; A61L27/50; A61L27/52; A61L31/00; A61L31/04; A61L31/042; A61L31/14; A61L31/145; C; C08; C08L; C08L5/00; C08L5/08; H; H04; H04B; H04B10/00; H04B10/50; Y; Y10; Y10S; Y10S530/00; Y10S530/81; Y10S530/812; Y10S530/813
Claims Analysis
Total Claims: 17
Claim 1
Independent Claim
47 words
A biocompatible viscoelastic gel slurry comprising a two phase mixture, a first phase comprising particles of a biocompatible gel swollen in a physiologically acceptable aqueous medium, and which is uniformly distributed in a second phase comprising a solution of a biocompatible polymer in the same aqueous medium.
Claim 2
Dependent Claim
36 words
A biocompatible viscoelastic gel slurry as claimed in Claim 1, characterised in that the biocompatible gel comprises a chemically crosslinked polymer selected from natural polymers and synthetic polymers having reactive groups suited for a crosslinking reaction.
Claim 3
Dependent Claim
39 words
A biocompatible viscoelastic gel slurry as claimed in Claim 1 or Claim 2, characterised in that the biocompatible gel comprises a chemically crosslinked mixture of a polymer having a high degree of biocompatibility and at least one other polymer.
Claim 4
Dependent Claim
30 words
A biocompatible viscoelastic gel slurry as claimed in any preceding claim, characterised in that the biocompatible soluble polymer is selected from natural polymers and synthetic polymers soluble in aqueous media.
Claim 5
Dependent Claim
27 words
A biocompatible viscoelastic gel slurry as claimed in any one of Claims 2 to 4, characterised in that the chemically crosslinked gel-forming polymer is hyaluronan or hylan.
Claim 6
Dependent Claim
54 words
A biocompatible viscoelastic gel slurry as claimed in any preceding claim, characterised in that the physiologically acceptable aqueous medium is a water solution of a salt of an alkali or alkaline-earth metal and an anion selected from chloride, sulfate, phosphate, acid phosphate, bicarbonate, acetate, lactate, glycolate, glucuronate and galacturonate and a neutral organic substance.
Claim 7
Dependent Claim
24 words
A biocompatible viscoelastic gel slurry as claimed in Claim 6, characterised in that the neutral organic substance is selected from carbohydrates and polyhydric alcohols.
Claim 8
Dependent Claim
33 words
A biocompatible viscoelastic gel slurry as claimed in any preceding claim, characterised in that the polymer concentration of the biocompatible gel swollen in the physiologically acceptable aqueous medium is from 0.01 to 30%.
Claim 9
Dependent Claim
27 words
A biocompatible viscoelastic gel slurry as claimed in any preceding claim, characterised in that the polymer concentration of the polymer solution phase is from 0.01 to 70%.
Claim 10
Dependent Claim
31 words
A biocompatible viscoelastic gel slurry as claimed in any preceding claim, characterised in that the polymer solution in the mixture constitutes from 0.01 to 99.5%, the remainder being the gel phase.
Claim 11
Dependent Claim
45 words
A method of obtaining a biocompatible viscoelastic gel slurry according to Claim 1, which comprises mixing a biocompatible polymeric gel swollen in a physiologically acceptable aqueous medium, with a solution of a biocompatible polymer in the same aqueous medium, and disintegrating the gel into particles.
Claim 12
Dependent Claim
33 words
A method of obtaining the biocompatible viscoelastic gel slurry as claimed in Claim 13, wherein disintegrating of the gel into particles is performed before or after mixing the gel with the polymer solution.
Claim 13
Dependent Claim
44 words
A method of obtaining the biocompatible viscoelastic gel slurry as claimed in Claim 11 or Claim 12, characterised in that the biocompatible polymeric gel is obtained by crosslinking of a biocompatible polymer with subsequent swelling thereof to equilibrium in a physiologically acceptable aqueous medium.
Claim 14
Dependent Claim
47 words
A method of obtaining the biocompatible viscoelastic gel slurry as claimed in Claim 11 or Claim 12, characterised in that the biocompatible polymeric gel is obtained by permitting to swell to equilibrium in a physiologically acceptable aqueous medium a biocompatible polymer which is not soluble in water.
Claim 15
Dependent Claim
48 words
A method of obtaining the biocompatible viscoelastic gel slurry as claimed in Claim 11 or Claim 12, characterised in that the swelling of the polymeric gel is reduced as compared to the extent of swelling at equilibrium by partially removing the physiologically acceptable aqueous medium from the gel.
Claim 16
Dependent Claim
41 words
A method of obtaining the biocompatible viscoelastic gel slurry as claimed in Claim 15, characterised in that the partial removal of the physiologically acceptable aqueous medium from the gel is achieved by compressing and/or centrifuging the gel previously swollen to equilibrium.
Claim 17
Dependent Claim
77 words
A method of controlling the rheological and diffusion properties of the biocompatible viscoelastic gel slurry as defined in Claim 1, comprising one or more of the following steps: (i) changing the polymer concentration in the gel phase; (ii) partial removal of the physiologically acceptable aqueous medium from the gel previously swollen to equilibrium; (iii) changing the polymer concentration in the polymer solution phase; and (iv) changing the ratio of the gel phase to the polymer solution phase.
References Cited (Backward Citations)
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