Xenogeneic collagen/mineral preparations in bone repair

Claim 2

A composition for use in bone repair, which composition comprises a mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component obtained from mineral particles of non-biological origin in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen.

Claim 3

The composition of claim 1 wherein the mineral component is hydroxyapatite or tricalcium phosphate, or a mixture thereof, and wherein the particles are 100-2000 u.

Claim 4

The composition of claim 1 which contains less than 1% water.

Claim 5

The composition of claim 3 which has a 2 compression modulus >6 N/cm .

Claim 6

A prosthesis for bone repair which comprises a porous, rigid calcium phosphate mineral block wherein the pores are infiltrated with a collagen preparation resulting in a coating of the pores with atelopeptide reconstituted fibrillar collagen.

Claim 7

A prosthesis for bone repair which comprises a porous, rigid calcium phosphate mineral block wherein the pores are infiltrated with a collagen preparation resulting in a coating of the pores with atelopeptide reconstituted fibrillar collagen.

Claim 8

A process for coating the pores in a porous block of calcium phosphate mineral material with collagen, which process comprises pumping a collagen dispersion through the mineral material which has been placed in a mold. leaving an inlet port and an outlet port, by pumping said dispersion into the inlet port through said porous material and out the outlet port.

Claim 9

A process for coating the pores in a porous block of calcium phosphate mineral material with collagen, which process comprises pumping a collagen dispersion through the mineral material which has been placed in a mold. leaving an inlet port and an outlet port, by pumping said dispersion into the inlet port through said porous material and out the outlet port.

Claim 10

A composition which is the product of the process of claim 6.

Claim 11

A process for preparing a composition for use in bone repair, which composition is prepared from a dried mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen component, said mixture containing less than 1% water, which process is selected from the group consisting Q f: a) subjecting said mixture to a temperature of 60-120°C for 4-168 hours; and b) soaking said mixture in a solution containing cross-linking agent, removing said cross-linking agent, and redrying the mixture to a moisture content of less than 1%.

Claim 12

A process for preparing a composition for use in bone repair, which composition is prepared from a dried mixture consisting essentially of 60-98% by weight of a calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen component, said mixture containing less than 1% water, which process is selected from the group consisting Q f: a) subjecting said mixture to a temperature of 60-120°C for 4-168 hours; and b) soaking said mixture in a solution containing cross-linking agent, removing said cross-linking agent, and redrying the mixture to a moisture content of less than 1%.

Claim 13

A composition which is the product of the process of claim 8.

Claim 14

A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting of essentially 6o-98% by weight of calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen, which process is selected from the group consisting of: a) incubating said mixture in the presence of water at approximately 37°C for 1-10 days, followed by drying said mixture to a moisture content of less than 1%, optionally followed by subjecting the dried mixture to a temperature of 60-120°C for 4-168 hours: b) exposing said mixture in the presence of water to the vapors of a cross-linking agent for a time and at a temperature effective to effect cross-linking of the collagen component, followed by drying said mixture to a moisture content of less than 1% by weight. optionally followed by subjecting the dried mixture to a temperature of 60-120°C for 4-168 hours; and c) soaking said mixture in a solution containing cross-linking agent, removing said cross-linking agent, and drying the mixture to a moisture content of less than 1%, optionally followed by subjecting the dried mixture to a temperature of 60-120°C for 4-168 hours.

Claim 15

A process for preparing a composition for use in bone repair, which composition comprises a mixture consisting of essentially 6o-98% by weight of calcium phosphate mineral component in admixture with 2-40% of an atelopeptide reconstituted fibrillar collagen, which process is selected from the group consisting of: a) incubating said mixture in the presence of water at approximately 37°C for 1-10 days, followed by drying said mixture to a moisture content of less than 1%, optionally followed by subjecting the dried mixture to a temperature of 60-120°C for 4-168 hours: b) exposing said mixture in the presence of water to the vapors of a cross-linking agent for a time and at a temperature effective to effect cross-linking of the collagen component, followed by drying said mixture to a moisture content of less than 1% by weight. optionally followed by subjecting the dried mixture to a temperature of 60-120°C for 4-168 hours; and c) soaking said mixture in a solution containing cross-linking agent, removing said cross-linking agent, and drying the mixture to a moisture content of less than 1%, optionally followed by subjecting the dried mixture to a temperature of 60-120°C for 4-168 hours.